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1.发明申请Methods and compositions for pharmacologially controlled targeted immunotherapy 审中-公开用于药理学靶向免疫治疗的方法和组合物公开(公告)号：US20070134259A1
公开(公告)日：2007-06-14
申请号：US11602493
申请日：2006-11-21
申请人： David Bundle , Pavel Kitov , Gordon Grant , Tomek Lipinski , Sebastian Dziadek
发明人： David Bundle , Pavel Kitov , Gordon Grant , Tomek Lipinski , Sebastian Dziadek
IPC分类号： A61K39/00 , A61K38/12 , A61K31/739 , A61K31/715 , A61K31/655
CPC分类号： C07K5/0817 , A61K38/00 , A61K39/0011 , A61K2039/6012 , C07K7/64
摘要： The present invention relates generally to methods and compositions for targeted immunotherapy. More specifically, the present invention relates to immuno-targeted therapies, using heteromultivalent compounds to mediate the binding of an endogenous effector molecule such as an antibody to target molecules including malignant cells and tissues, bacteria and viruses as well as their toxic agents.
摘要翻译： 本发明一般涉及用于靶向免疫治疗的方法和组合物。 更具体地，本发明涉及免疫靶向治疗，其使用异成分化合物介导内源效应分子例如抗体与包括恶性细胞和组织，细菌和病毒的靶分子以及它们的毒性剂的结合。
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公开(公告)号：US07553819B2
公开(公告)日：2009-06-30
申请号：US10556333
申请日：2004-05-12
CPC分类号： C07D295/185 , A61K47/549 , A61K47/55 , C07D303/30 , C07D319/06 , C07D319/12 , C07D405/14 , C07D407/12 , C07D407/14 , C08B37/00
摘要： Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are useful for treating amyloidosis and diseases associated with amyloidosis, for example Alzheimer&supl;s disease and maturity onset diabetes mellitus.
摘要翻译： 制备新型甘油环丙酮酸衍生物，并证实其已经制备了抑制固定化的D-脯氨酸衍生物与血清淀粉样蛋白P组分（SAP）的结合。 因此，本发明的化合物可用于治疗淀粉样变性和与淀粉样变性相关的疾病，例如阿尔茨海默病和成熟期糖尿病。
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公开(公告)号：US20070042936A1
公开(公告)日：2007-02-22
申请号：US10556333
申请日：2004-05-12
申请人： David Bundle , Pavel Kitov , Kenneth Ng , Jason Ho
发明人： David Bundle , Pavel Kitov , Kenneth Ng , Jason Ho
IPC分类号： A61K38/00 , A61K31/7048 , A61K31/41 , A61K31/335
CPC分类号： C07D295/185 , A61K47/549 , A61K47/55 , C07D303/30 , C07D319/06 , C07D319/12 , C07D405/14 , C07D407/12 , C07D407/14 , C08B37/00
摘要： Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are useful for treating amyloidosis and diseases associated with amyloidosis, for example Alzheimer&supl;s disease and maturity onset diabetes mellitus.
摘要翻译： 制备新型甘油环丙酮酸衍生物，并证实其已经制备了抑制固定化的D-脯氨酸衍生物与血清淀粉样蛋白P组分（SAP）的结合。 因此，本发明的化合物可用于治疗淀粉样变性和与淀粉样变性相关的疾病，例如阿尔茨海默病和成熟期糖尿病。
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公开(公告)号：US20060058506A1
公开(公告)日：2006-03-16
申请号：US10512216
申请日：2003-04-25
申请人： David Bundle , Mark Nitz , Jim Cutler
发明人： David Bundle , Mark Nitz , Jim Cutler
CPC分类号： A61K47/646 , A61K47/65
摘要： The present invention provides methods of making and using immunogenic oligosaccharide compositions comprising native O-linked and S-linked oligosaccharides coupled to a protein carrier, wherein the resultant conjugate elicits a protectively immunogenic response. These compositions may be useful in vaccines against pathogenic Candida species.
摘要翻译： 本发明提供了制备和使用免疫原性寡糖组合物的方法，所述组合物包含与蛋白质载体偶联的天然O-连接和S-连接的寡糖，其中所得的缀合物引起保护性免疫原性应答。 这些组合物可用于抗病原体假丝酵母属物种的疫苗中。
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