公开(公告)号：US20130231352A1

公开(公告)日：2013-09-05

申请号：US13884698

申请日：2011-11-17

申请人： Timothy David Cushing ,  Julia Winslow Lohman ,  Youngsook Shin

发明人： Timothy David Cushing ,  Julia Winslow Lohman ,  Youngsook Shin

IPC分类号： C07D401/14 ,  C07D413/14

CPC分类号： A61K31/506 ,  C07D239/42 ,  C07D401/14 ,  C07D413/14

摘要： Substituted bicyclic heteroaryls having the general formula (I) and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p1 108 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML), Myelodysplastic syndrome (MDS), myelo-proliferative diseases (MPD), Chronic Myeloid Leukemia (CML), T-cell Acute Lymphoblastic leukaemia (T-ALL), B-cell Acute Lymphoblastic leukaemia (B-ALL), Non Hodgkins Lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 具有通式（I）的取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症组分 慢性炎性病症，包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的过敏症状 本发明还使得能够治疗依赖于p1 108活性或与p1108活性有关的癌症的方法，所述癌症包括但不限于白血病，例如急性骨髓性白血病（AML），骨髓增生异常综合征（MDS），骨髓增殖性 疾病 （MPD），慢性骨髓性白血病（CML），T细胞急性淋巴细胞白血病（T-ALL），B细胞急性淋巴细胞白血病（B-ALL），非霍奇金淋巴瘤（NHL），B细胞淋巴瘤和实体瘤， 如乳腺癌。

公开(公告)号：US08306900B2

公开(公告)日：2012-11-06

申请号：US10457479

申请日：2003-06-10

申请人： Tomas Bok ,  David Cushing

发明人： Tomas Bok ,  David Cushing

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04

摘要： An auto-trading strategy for executing an order to buy or sell a specified quantity of a certain item. The strategy utilizes urgency scores rather than time bins. In one embodiment, an urgency score is determined at a certain point in time. The urgency score is a function of a trading target associated with the point in time and the actual number of items that have been traded as of the certain point in time.

摘要翻译： 一种自动交易策略，用于执行订单以购买或出售指定数量的某一项目。 该策略利用紧急分数而不是时间段。 在一个实施例中，在某个时间点确定紧急度得分。 紧急分数是与时间点相关联的交易目标的函数，以及在某一时间点交易的实际项目数量。

公开(公告)号：US20090083175A1

公开(公告)日：2009-03-26

申请号：US12236651

申请日：2008-09-24

申请人： David CUSHING

发明人： David CUSHING

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q30/08 ,  G06Q40/00

摘要： A method and system for performing a batch auction whereby a series of orders, according to a variety of predetermined order types, are generated by qualified market participants and communicated to an auction system. The auction system takes into account each order and its impact upon relative supply and demand to determine by a preset algorithm a price and share transaction quantity. Trades are executed at the price, and a portion of the transaction quantity is allocated to each investor on a fair basis dependent upon their initial orders. In embodiments of the present invention, the auction system uses a computer system or network designed to automatically perform one or more steps of the above method. Such a system is preferably connected to one or more ECNs such that non-executed shares can be automatically sent to outside sources for execution. In alternative embodiments, the invention includes the use of a one or more intermediaries or market makers to cover certain unexecuted trades at the determined price. The present invention is preferably used to conduct batch auctions at the opening and closing of securities trading markets.

摘要翻译： 一种用于执行批量拍卖的方法和系统，其中根据各种预定顺序类型的一系列订单由合格的市场参与者产生并传送给拍卖系统。 拍卖系统考虑到每个订单及其对相对供应和需求的影响，通过预设算法确定价格和交易数量。 交易以价格执行，交易数量的一部分根据其初始订单以公平的方式分配给每个投资者。 在本发明的实施例中，拍卖系统使用被设计为自动执行上述方法的一个或多个步骤的计算机系统或网络。 这样的系统优选地连接到一个或多个ECN，使得非执行共享可以被自动发送到外部来执行。 在替代实施例中，本发明包括使用一个或多个中间商或营销商以确定的价格来覆盖某些未执行的交易。 本发明优选用于在证券交易市场开市时进行批量拍卖。

公开(公告)号：US08765768B2

公开(公告)日：2014-07-01

申请号：US13884698

申请日：2011-11-17

申请人： Timothy David Cushing ,  Julia Winslow Lohman ,  Youngsook Shin

发明人： Timothy David Cushing ,  Julia Winslow Lohman ,  Youngsook Shin

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04 ,  A61K31/506

CPC分类号： A61K31/506 ,  C07D239/42 ,  C07D401/14 ,  C07D413/14

摘要： Substituted bicyclic heteroaryls having the general formula (I) and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p1 108 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML), Myelodysplastic syndrome (MDS), myelo-proliferative diseases (MPD), Chronic Myeloid Leukemia (CML), T-cell Acute Lymphoblastic leukaemia (T-ALL), B-cell Acute Lymphoblastic leukaemia (B-ALL), Non Hodgkins Lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 具有通式（I）的取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症组分 慢性炎性病症，包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的过敏症状 本发明还使得能够治疗依赖于p1 108活性或与p1108活性有关的癌症的方法，所述癌症包括但不限于白血病，例如急性骨髓性白血病（AML），骨髓增生异常综合征（MDS），骨髓增殖性 疾病 （MPD），慢性骨髓性白血病（CML），T细胞急性淋巴细胞白血病（T-ALL），B细胞急性淋巴细胞白血病（B-ALL），非霍奇金淋巴瘤（NHL），B细胞淋巴瘤和实体瘤， 如乳腺癌。

公开(公告)号：US08112385B2

公开(公告)日：2012-02-07

申请号：US11473916

申请日：2006-06-23

申请人： Soufiane Azizi ,  David Cushing

发明人： Soufiane Azizi ,  David Cushing

IPC分类号： G06F7/00 ,  G06F17/00

CPC分类号： G06F17/30554

摘要： A query that is based on a predefined format of an arbitrary query language is received. A data analyzing component performs the query to obtain a query result. The query result and a report layout specification are provided from the data analyzing component to a data processing component, the data processing component being on a computer. The data processing component associates the query result with at least one element of the report layout specification to generate an association. The query result is provided from the data processing component through an interface based on the report layout specification without reliance on the type of the arbitrary query language to a rendering component. The report layout specification is provided from the data analyzing component to the rendering component to render the query result in a report according to the association without reliance on the type of the arbitrary query language.

摘要翻译： 接收基于任意查询语言的预定义格式的查询。 数据分析组件执行查询以获得查询结果。 查询结果和报告布局规范从数据分析组件提供给数据处理组件，数据处理组件位于计算机上。 数据处理组件将查询结果与报告布局规范的至少一个元素相关联以生成关联。 查询结果通过基于报告布局规范的接口从数据处理组件提供，而不依赖于渲染组件的任意查询语言的类型。 报告布局规范从数据分析组件提供给呈现组件，以根据关联将查询结果呈现在报告中，而不依赖于任意查询语言的类型。

公开(公告)号：US20090307200A1

公开(公告)日：2009-12-10

申请号：US12477627

申请日：2009-06-03

申请人： Liviu IGNAT ,  Soufiane AZIZI ,  David CUSHING

发明人： Liviu IGNAT ,  Soufiane AZIZI ,  David CUSHING

IPC分类号： G06F17/30 ,  G06F15/16

CPC分类号： G06F16/24564 ,  G06F16/283

摘要： A suppression provider comprises a query preparation unit and a query execution unit. The query preparation unit analyzes a request from a client for data to obtain suppression criteria from an edge suppression specification in the request, and saving the suppression criteria in a query plan generated. The query execution unit receives execution result data including values, each associated with one or more edge values, determines if each value is to be suppressed based on the suppression criteria, and identifies one or more edge values to be suppressed when an edge value has only values that are determined to be suppressed. Thus, the suppression provider suppresses values and/or edge values identified to be suppressed in a resultant report.

摘要翻译： 抑制提供者包括查询准备单元和查询执行单元。 查询准备单元从客户端分析来自请求中的边缘抑制规范的数据获得抑制标准的请求，并且在生成的查询计划中保存抑制标准。 查询执行单元接收包括与一个或多个边缘值相关联的值的执行结果数据，基于抑制准则来确定是否要抑制每个值，并且当边缘值仅具有标识时识别待抑制的一个或多个边缘值 确定被抑制的值。 因此，抑制提供者抑制在得到的报告中识别为被抑制的值和/或边缘值。

公开(公告)号：US07430533B1

公开(公告)日：2008-09-30

申请号：US09480991

申请日：2000-01-11

申请人： David Cushing

发明人： David Cushing

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q30/08 ,  G06Q40/00

摘要： A method and system for performing a batch auction whereby a series of orders, according to a variety of predetermined order types, are generated by qualified market participants and communicated to an auction system. The auction system takes into account each order and its impact upon relative supply and demand to determine by a preset algorithm a price and share transaction quantity. Trades are executed at the price, and a portion of the transaction quantity is allocated to each investor on a fair basis dependent upon their initial orders. In embodiments of the present invention, the auction system uses a computer system or network designed to automatically perform one or more steps of the above method. Such a system is preferably connected to one or more ECNs such that non-executed shares can be automatically sent to outside sources for execution. In alternative embodiments, the invention includes the use of a one or more intermediaries or market makers to cover certain unexecuted trades at the determined price. The present invention is preferably used to conduct batch auctions at the opening and closing of securities trading markets.

摘要翻译： 一种用于执行批量拍卖的方法和系统，其中根据各种预定顺序类型的一系列订单由合格的市场参与者产生并传送给拍卖系统。 拍卖系统考虑到每个订单及其对相对供应和需求的影响，通过预设算法确定价格和交易数量。 交易以价格执行，交易数量的一部分根据其初始订单以公平的方式分配给每个投资者。 在本发明的实施例中，拍卖系统使用被设计为自动执行上述方法的一个或多个步骤的计算机系统或网络。 这样的系统优选地连接到一个或多个ECN，使得非执行共享可以被自动发送到外部来执行。 在替代实施例中，本发明包括使用一个或多个中间商或营销商以确定的价格来覆盖某些未执行的交易。 本发明优选用于在证券交易市场开市时进行批量拍卖。

公开(公告)号：US20070299676A1

公开(公告)日：2007-12-27

申请号：US11473616

申请日：2006-06-23

申请人： Glen Seeds ,  David Cushing ,  Henk Cazemier

发明人： Glen Seeds ,  David Cushing ,  Henk Cazemier

IPC分类号： G06Q10/00 ,  G05B19/418 ,  G06Q30/00 ,  G06F9/46

CPC分类号： G06F17/30592 ,  G06Q10/0637

摘要： A member unique name (MUN) system and MUN translation system and method are provided. The MUN system comprises a dimension reference for defining the context in which the remaining portions of the MUN exist and a canonical business key for uniquely identifying a member across different dimensional data sources within a business enterprise. The MUN translation system comprises a translation selection module for selecting a MUN transformation and a collection of MUN transformations for transforming a MUN of a first data source into a MUN of the second data source.

摘要翻译： 提供会员唯一名称（MUN）系统和MUN翻译系统和方法。 MUN系统包括用于定义存在MUN的剩余部分的上下文的维度参考，以及用于在商业企业内的不同维度数据源上唯一地标识成员的规范商业密钥。 MUN翻译系统包括用于选择MUN变换的转换选择模块和用于将第一数据源的MUN变换为第二数据源的MUN的MUN变换的集合。

公开(公告)号：US20070038550A1

公开(公告)日：2007-02-15

申请号：US11387994

申请日：2006-03-22

申请人： Barthelemy Caille ,  Gregoire Schneider ,  David Cushing ,  Tomas Bok ,  Joe Loftus ,  Mike Eckert ,  Joe Corcoran ,  Art Ayzerov ,  Robert Saffer

发明人： Barthelemy Caille ,  Gregoire Schneider ,  David Cushing ,  Tomas Bok ,  Joe Loftus ,  Mike Eckert ,  Joe Corcoran ,  Art Ayzerov ,  Robert Saffer

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04

摘要： In at one aspect, the invention comprises an interactive software toolkit for creating custom trading strategies. Traders are provided with the ability to easily construct hybrid strategies using automated trading and event building blocks: (a) trading algorithms (for example, so-called “percentage of volume” algorithms and algorithms designed to minimize the difference between average executed price and standardized benchmarks such as volume-weighted average price (“VWAP”)); (b) intelligent “sweeps” (automated trading actions designed to rapidly execute a specified number of shares); and (c) event triggers (time-, price-, spread-, depth-based, or based on other real-time market data or on current order status). Traders can create and store a set of custom strategies tailored to specific order types or trading styles.

摘要翻译： 在一方面，本发明包括用于创建自定义交易策略的交互式软件工具包。 交易者具有使用自动交易和事件构建模块轻松构建混合策略的能力：（a）交易算法（例如，所谓的“体积百分比”算法和算法，旨在最小化平均执行价格与标准化之间的差异 诸如体重加权平均价格（“VWAP”）等基准; （b）智能“扫荡”（旨在迅速执行指定数量股份的自动交易行动）; 和（c）事件触发（时间，价格，传播，深度或基于其他实时市场数据或当前订单状态）。 交易者可以创建和存储一套针对特定订单类型或交易方式的自定义策略。

公开(公告)号：US20070011081A1

公开(公告)日：2007-01-11

申请号：US11485030

申请日：2006-07-11

申请人： Tomas Bok ,  David Cushing ,  David Jack ,  Sanjoy Choudhury

发明人： Tomas Bok ,  David Cushing ,  David Jack ,  Sanjoy Choudhury

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q30/08 ,  G06Q40/06

摘要： In one aspect, the present invention permits users of trading algorithms to jointly achieve the objectives described above, namely: (a) permit access to trading algorithms of (arbitrary) complexity without requiring proprietary protocol extensions; (b) allow users to easily identify and store one or more sets of dynamic vs. static parameters (and related details, including user interface layout); and (c) allow any given pre-defined set of parameters to be easily invoked and used to submit orders. In another aspect, the invention comprises a computer system comprising: (a) an authoring tool operable to enable a user to design custom trading strategies and create interface definitions; and (b) a pre-processor operable to receive a custom strategy order message delivered via a standard protocol, load an definition for a corresponding custom strategy, enrich the order message based on the definition, and pass the enriched message to a trading strategy destination.

摘要翻译： 一方面，本发明允许交易算法的用户共同实现上述目标，即：（a）允许访问（任意）复杂的交易算法，而不需要专有的协议扩展; （b）允许用户轻松识别和存储一组或多组动态与静态参数（以及相关细节，包括用户界面布局）; 和（c）允许任何给定的预先定义的一组参数被轻易地调用并用于提交订单。 在另一方面，本发明包括一种计算机系统，包括：（a）创作工具，其可操作以使用户能够设计定制交易策略并创建界面定义; 和（b）预处理器，其可操作以接收经由标准协议传递的定制策略订单消息，加载相应定制策略的定义，基于该定义丰富订单消息，并将所述富集消息传递到交易策略目的地 。