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    Multiple disk refiner for low consistency refining of mechanical pulp
    1.
    发明授权
    Multiple disk refiner for low consistency refining of mechanical pulp 失效
    用于机械纸浆低浓度精炼的多盘精磨机

    公开(公告)号：US4529137A

    公开(公告)日：1985-07-16

    申请号：US486005

    申请日：1983-04-18

    申请人： John B. Matthew ,  David H. Robinson

    发明人： John B. Matthew ,  David H. Robinson

    IPC分类号： B02C7/06 ,  D21B1/14 ,  D21D1/30 ,  B02C7/12

    CPC分类号： D21D1/303

    摘要： A refiner comprising a housing having a refining chamber providing a flow path for particulate material to be refined while travelling between an upstream inlet and a downstream outlet. A refining assembly in the chamber has a series of relatively rotatably cooperative axially confronting annular refining surfaces located on partially internested refining disks and defining radially extending refining zones therebetween and with radially opposite ends of the zones closed. Passages defined by and between the internested portions of the disks connect the adjacent refining zones in a manner to cause the particulate material such as paper making stock to pass successively between the radially outer ends of the zones and the radially inner ends of the zones.

    摘要翻译： 一种精磨机，其包括具有精炼室的壳体，所述精炼室为在上游入口和下游出口之间行进时精细化的颗粒材料提供流动路径。 腔室中的精炼组件具有一系列相对可旋转地协调的轴向相对的环形精炼表面，其位于部分内部的精制圆盘上并且在其间限定径向延伸的精炼区域，并且所述区域的径向相对端部被封闭。 通过盘片的内嵌部分之间和之间的通道以相邻的精炼区域的方式连接，以使诸如造纸原料的颗粒材料在区域的径向外端和区域的径向内端之间相继通过。

    1,3,4-thiadiazoles
    2.
    发明授权
    1,3,4-thiadiazoles 失效
    1,3,4-噻二唑

    公开(公告)号：US4927822A

    公开(公告)日：1990-05-22

    申请号：US901048

    申请日：1986-08-27

    申请人： Roger C. Brown ,  John Dixon ,  David H. Robinson

    发明人： Roger C. Brown ,  John Dixon ,  David H. Robinson

    IPC分类号： A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/54 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07D249/12 ,  C07D253/06 ,  C07D271/10 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D285/16 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07K5/02 ,  C07K5/068 ,  C12N9/99

    CPC分类号： C07D253/06 ,  C07D271/10 ,  C07D285/12 ,  C07D285/135 ,  C07D285/16 ,  C07D417/04 ,  C07K5/0222 ,  C07K5/06086 ,  A61K38/00

    摘要： There are described compounds of formula I, ##STR1## in which Y is S, O or NR.sub.9,n is 0 or 1,R.sub.9 is hydrogen or alkyl C 1 to 10,R.sub.3 is hydrogen, alkyl C 1 to 10, cycloalkyl C3 to 10, CF.sub.3, SR.sub.10, a 5 or 6 membered heterocyclic group containing one or more S, O or N atoms, NR.sub.4 R.sub.5, phenyl or phenylalkyl C7 to 12, the phenyl, phenylalkyl and heterocyclic groups optionally being fused to a further phenyl group, the heterocyclic group and any phenyl group optionally being substituted by alkyl C 1 to 6, halogen, alkoxy C 1 to 6, nitro, nitrile, CF.sub.3, SR.sub.6, NR.sub.7 R.sub.11 or hydroxy,R.sub.6, R.sub.7 and R.sub.11, which may be the same or different, are each hydrogen or alkyl C 1 to 10,R.sub.4 and R.sub.5, which may be the same or different, are each hydrogen, alkyl C 1 to 10 or phenyl,R.sub.10 is alkyl C 1 to 10,X.sub.1 is S or O, andA is a chain comprising from 2-16 atoms, which chain carries an O or S containing substitutent at a position 2-6 atoms away from the group C=X.sub.1,and pharmaceutically acceptable salts, esters and amides thereof, p1 there are also described method of making the compounds and pharmaceutical formulations, e.g. for the treatment of hypertension, containing them.

    摘要翻译： 描述了式I的化合物，其中Y是S，O或NR9，n是0或1，R9是氢或烷基C1至10，R3是氢，烷基C1至10，环烷基C3 至10，CF 3，SR 10，含有一个或多个S，O或N原子的5或6元杂环基，NR 4 R 5，苯基或苯基烷基C 7至12，任选地与另外的苯基稠合的苯基，苯基烷基和杂环基， 杂环基和任选被烷基C 1-6取代的任何苯基，卤素，烷氧基C 1至6，硝基，腈，CF 3，SR 6，NR 7 R 11或羟基，R 6，R 7和R 11可以相同或不同 各自为氢或烷基C 1至10，R 4和R 5可以相同或不同，各自为氢，烷基C 1至10或苯基，R 10为烷基C 1至10，X 1为S或O，以及 A是包含2-16个原子的链，该链在距离基团C = X1的2-6个原子的位置上携带含有O或S的取代基，以及药学上可接受的盐，酯和酰胺 除此之外，还描述了制备化合物和药物制剂的方法，例如， 用于治疗高血压，包含它们。