公开(公告)号：US4258152A

公开(公告)日：1981-03-24

申请号：US47909

申请日：1979-06-12

申请人： Gideon Goldstein ,  David H. Schlesinger

发明人： Gideon Goldstein ,  David H. Schlesinger

IPC分类号： A61K38/00 ,  C07K5/062 ,  C08F8/30

CPC分类号： C07K5/06052 ,  A61K38/00 ,  Y10S930/28

摘要： There are disclosed polypeptide compositions having the following amino acid sequence as the active site:ARG-LYS-ASP-VAL-TYRThese polypeptides have the capability of inducing the differentiation of T-lymphocytes but not of complement receptor (CR.sup.+) B-lymphocytes and thus are useful in a number of therapeutic areas. Also provided are derivatives of the pentapeptide, novel intermediate polypeptides, methods of manufacture of the peptides, therapeutic compositions, and methods for use of the compositions.

摘要翻译： 公开了具有以下氨基酸序列作为活性位点的多肽组合物：ARG-LYS-ASP-VAL-TYR这些多肽具有诱导T淋巴细胞分化而不是补体受体（CR +）B淋巴细胞分化的能力， 因此在许多治疗领域中是有用的。 还提供了五肽的衍生物，新的中间体多肽，肽的制备方法，治疗组合物和使用该组合物的方法。

公开(公告)号：US4769235A

公开(公告)日：1988-09-06

申请号：US695257

申请日：1985-01-28

申请人： David H. Schlesinger ,  Victor N. Nussenzweig

发明人： David H. Schlesinger ,  Victor N. Nussenzweig

IPC分类号： A61K39/00 ,  A61K39/015 ,  C07K14/445 ,  C07K16/20 ,  C07K7/06 ,  C07K7/00

CPC分类号： C07K14/445 ,  A61K39/015 ,  C07K16/205 ,  A61K39/00

摘要： Disclosed are peptides the sequence of which defines an immunodominant epitope from the repetitive immunodominant epitope region of the circumsporozoite (CS) protein of a member of the genus Plasmodium, the sequence of the peptide being shorter in length than the repeating unit of the CS protein.

摘要翻译： 披露的是其序列定义来自疟原虫属成员的环子孢子（CS）蛋白的重复免疫优势表位区域的免疫显性表位的肽，其长度比CS蛋白重复单位短。

公开(公告)号：US4190647A

公开(公告)日：1980-02-26

申请号：US6894

申请日：1979-01-26

申请人： Gideon Goldstein ,  David H. Schlesinger

发明人： Gideon Goldstein ,  David H. Schlesinger

IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K14/575 ,  A61K37/00 ,  C07C103/52 ,  C08L37/00

CPC分类号： C07K7/06 ,  C07K14/575 ,  A61K38/00

摘要： There are disclosed new polypeptide compositions having the following amino acid sequence as the active site:TYR-ASN-ILE-GLN-LYSThis polypeptide has the capability of inducing the differentiation of both T-precursor cells as measured by the acquisition of the thymic differentiation antigens TL and THY-1 (.theta.), as well as B-precursor cells as measured by the acquisition of receptors for complement, a distinctive marker of B cells. The peptide is thus useful in thymic function and immunity areas such as in treatment for a congenital absence of thymus. The peptide is active in very low concentrations. Also provided are derivatives of the pentapeptide, novel intermediate polypeptides, methods of manufacture of the peptides, therapeutic compositions, and methods for use of the compositions.

摘要翻译： 公开了具有以下氨基酸序列作为活性位点的新的多肽组合物：TYR-ASN-ILE-GLN-LYS该多肽具有诱导两种T前体细胞分化的能力，如通过获得胸腺分化所测量的 抗原TL和THY-1（θ），以及通过获得补体受体（B细胞的独特标记物）测量的B前体细胞。 因此，该肽可用于胸腺功能和免疫领域，例如先天性缺乏胸腺的治疗。 该肽在非常低的浓度下是有活性的。 还提供了五肽的衍生物，新的中间体多肽，肽的制备方法，治疗组合物和使用该组合物的方法。

公开(公告)号：US4258151A

公开(公告)日：1981-03-24

申请号：US47907

申请日：1979-06-12

申请人： Gideon Goldstein ,  David H. Schlesinger

发明人： Gideon Goldstein ,  David H. Schlesinger

IPC分类号： A61K38/00 ,  C07K5/072 ,  C07K14/575 ,  C08F8/30

CPC分类号： C07K14/575 ,  C07K5/06104 ,  A61K38/00 ,  Y10S930/18 ,  Y10S930/28

摘要： There are disclosed new polypeptide compositions having the following amino acid sequence as the active site:TYR-ASN-ILE-GLN-LYSThis polypeptide has the capability of inducing the differentiation of both T-precursor cells as measured by the acquisition of the thymic differentiation antigens TL and THY-1 (.theta.), as well as B-precursor cells as measured by the acquisition of receptors for complement, a distinctive marker of B cells. The peptide is thus useful in thymic function and immunity areas such as in treatment for a congenital absence of thymus. The peptide is active in very low concentrations. Also provided are derivatives of the pentapeptide, novel intermediate polypeptides, methods of manufacture of the peptides, therapeutic compositions, and methods for use of the compositions.

摘要翻译： 公开了具有以下氨基酸序列作为活性位点的新的多肽组合物：TYR-ASN-ILE-GLN-LYS该多肽具有诱导两种T前体细胞分化的能力，如通过获得胸腺分化所测量的 抗原TL和THY-1（θ），以及通过获得补体受体（B细胞的独特标记物）测量的B前体细胞。 因此，该肽可用于胸腺功能和免疫领域，例如先天性缺乏胸腺的治疗。 该肽在非常低的浓度下是有活性的。 还提供了五肽的衍生物，新的中间体多肽，肽的制备方法，治疗组合物和使用该组合物的方法。

公开(公告)号：US4190646A

公开(公告)日：1980-02-26

申请号：US6893

申请日：1979-01-26

申请人： Gideon Goldstein ,  David H. Schlesinger

发明人： Gideon Goldstein ,  David H. Schlesinger

IPC分类号： A61K38/00 ,  C07K5/11 ,  C07K14/66 ,  A61K37/00 ,  C07C103/52 ,  C08L37/00

CPC分类号： C07K14/66 ,  C07K5/1019 ,  A61K38/00 ,  Y10S930/18

摘要： There are disclosed polypeptide compositions having the following amino acid sequence as the active site:ARG-LYS-ASP-VAL-TYRThese polypeptides have the capability of inducing the differentiation of T-lymphocytes but not of complement receptor (CR.sup.+) B-lymphocytes and thus are useful in a number of therapeutic areas. Also provided are derivatives of the pentapeptide, novel intermediate polypeptides, methods of manufacture of the peptides, therapeutic compositions, and methods for use of the compositions.

摘要翻译： 公开了具有以下氨基酸序列作为活性位点的多肽组合物：ARG-LYS-ASP-VAL-TYR这些多肽具有诱导T淋巴细胞分化而不是补体受体（CR +）B淋巴细胞分化的能力， 因此在许多治疗领域中是有用的。 还提供了五肽的衍生物，新的中间体多肽，肽的制备方法，治疗组合物和使用该组合物的方法。

公开(公告)号：US4002740A

公开(公告)日：1977-01-11

申请号：US606654

申请日：1975-08-21

申请人： Gideon Goldstein ,  David H. Schlesinger

发明人： Gideon Goldstein ,  David H. Schlesinger

IPC分类号： A61K38/00 ,  C07K14/66 ,  A61K37/00 ,  C07C103/52

CPC分类号： C07K14/66 ,  A61K38/00 ,  Y10S930/18 ,  Y10S930/28

摘要： There is disclosed a tridecapeptide of the following sequence:H.sub.2 N--Gly--Glu--Gln--Arg--Lys--Asp--Val--Tyr--Val--Gln--Leu--Tyr--Leu--COOHthis tridecapeptide has the capability of including the differentiation of T lymphocytes but not of complement receptor (CR.sup.+) B lymphocytes and thus is useful in a number of therapeutic areas. Also provided are novel intermediate polypeptides and methods of manufacture of the peptides.

摘要翻译： 公开了以下序列的十三肽：