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公开(公告)号:US20090274723A1
公开(公告)日:2009-11-05
申请号:US12310781
申请日:2007-09-10
IPC分类号: A61K39/285 , C12N7/00
CPC分类号: C12N15/86 , A61K39/12 , A61K39/285 , C12N7/00 , C12N2710/24143
摘要: The present invention relates, in general, to vaccines and, in particular, to a modified vaccinia Ankara (MVA) virus, to a composition comprising such a virus and to methods of using same to induce an immune response.
摘要翻译: 本发明一般涉及疫苗,特别是涉及修饰的痘苗安卡拉(MVA)病毒,涉及包含这种病毒的组合物以及使用它们诱导免疫应答的方法。
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公开(公告)号:US5578468A
公开(公告)日:1996-11-26
申请号:US113646
申请日:1993-08-31
IPC分类号: C12N15/863 , C12N15/10 , C12N1/21 , C12N5/10 , C12N15/11
CPC分类号: C12N15/86 , C12N2710/24143
摘要: The present invention relates to a method of effecting site-specific cleavage of RNA and to an element and a factor responsible for such cleavage.
摘要翻译: 本发明涉及实现RNA和元件的位点特异性切割以及造成这种切割的因素的方法。
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公开(公告)号:US5443964A
公开(公告)日:1995-08-22
申请号:US84406
申请日:1987-08-10
IPC分类号: C12N15/863 , C12N15/86 , C12N5/16 , C12N15/11 , C12P21/00
CPC分类号: C12N15/86 , C12N2710/24143
摘要: The invention comprises a plasmid vector, utilizing genetic material that causes high levels of expression of poxvirus genes, and the method of using this genetic material. One preferred embodiment comprises an upstream cis-acting element of a poxvirus gene encoding the major protein component of the poxvirus A-type inclusion. A second preferred embodiment of the invention comprises a downstream cis-acting element of a poxvirus gene encoding the major protein component of the poxvirus A-type inclusion. These elements are inserted upstream and downstream respectively, of selected cloned genes in the plasmid vector to obtain very high levels of expression of the cloned gene.
摘要翻译: 本发明包括使用导致痘病毒基因高水平表达的遗传物质的质粒载体,以及使用该遗传物质的方法。 一个优选的实施方案包括编码痘病毒A型包涵体的主要蛋白质成分的痘病毒基因的上游顺式作用元件。 本发明的第二个优选实施方案包括编码痘病毒A型包合物的主要蛋白质组分的痘病毒基因的下游顺式作用元件。 这些元件分别插入质粒载体中所选克隆基因的上游和下游,以获得克隆基因的非常高水平的表达。
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公开(公告)号:US07972605B2
公开(公告)日:2011-07-05
申请号:US12310781
申请日:2007-09-10
IPC分类号: A61K39/285 , C12N7/01 , C12N15/863
CPC分类号: C12N15/86 , A61K39/12 , A61K39/285 , C12N7/00 , C12N2710/24143
摘要: The present invention relates, in general, to vaccines and, in particular, to a modified vaccinia Ankara (MVA) virus, to a composition comprising such a virus and to methods of using same to induce an immune response.
摘要翻译: 本发明一般涉及疫苗,特别是涉及修饰的痘苗安卡拉(MVA)病毒,涉及包含这种病毒的组合物以及使用它们诱导免疫应答的方法。
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