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1.Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments 有权
标题翻译: 氨基 - 吲哚基取代的咪唑基 - 嘧啶及其作为药物的用途公开(公告)号:US09096579B2
公开(公告)日:2015-08-04
申请号:US13864394
申请日:2013-04-17
申请人: Georg Dahmann , Horst Dollinger , Christian Gnamm , Dennis Fiegen , Matthias Hoffmann , Jasna Klicic , David James Lamb , Andreas Schnapp
发明人: Georg Dahmann , Horst Dollinger , Christian Gnamm , Dennis Fiegen , Matthias Hoffmann , Jasna Klicic , David James Lamb , Andreas Schnapp
IPC分类号: A61K31/506 , A61K31/551 , A61K31/553 , A61K31/5386 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D498/10 , C07D209/42 , C07D403/06 , C07D487/04 , C07D409/14 , C07D403/14 , C07D405/14 , C07D401/14 , C07D413/14 , A61K45/06 , C07D417/14 , C07D471/04 , C07D487/10 , C07D498/04 , C07D513/04
CPC分类号: C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D209/42 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/04 , C07D498/10 , C07D513/04
摘要: The invention relates to new amino-indole-substituted imidazolyl-pyrimidines of formula 1 wherein R1, R2, R3, R4 and R5 are defined as in claim 1 and pharmaceutically acceptable salts thereof and the use of these compounds for the preparation of a medicament for treating a disease selected from asthma, COPD, rheumatoid arthritis, specific lymphomas and specific diseases of the nervous system.
摘要翻译: 本发明涉及式1的新的氨基 - 吲哚取代的咪唑基 - 嘧啶,其中R 1,R 2,R 3,R 4和R 5如权利要求1所定义,及其药学上可接受的盐,以及这些化合物用于制备 治疗选自哮喘,COPD,类风湿性关节炎,特异性淋巴瘤和神经系统的特定疾病的疾病。