公开(公告)号：US20080280950A1

公开(公告)日：2008-11-13

申请号：US11793358

申请日：2005-12-14

Applicant: David Waterson ,  David Jonas Persson

Inventor： David Waterson ,  David Jonas Persson

IPC: A61K31/454 ,  C07D401/12 ,  A61P19/02

CPC classification number: C07D401/12

Abstract: Formula (I) wherein R1 is a (2-4C)alkyl and is substituted by two or more fluorine groups and R2 is methyl or ethyl, or a pharmaceutically acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by metalloproteinase enzymes.

Abstract translation: 式（I）其中R 1是（2-4C）烷基并被两个或更多个氟基取代，R 2是甲基或乙基，或药学上可接受的 其盐 其制备方法，含有它们的药物组合物及其在治疗由金属蛋白酶介导的疾病或医学病症中的用途。

公开(公告)号：US08129412B2

公开(公告)日：2012-03-06

申请号：US11793358

申请日：2005-12-14

Applicant: David Waterson ,  David Jonas Persson

Inventor： David Waterson ,  David Jonas Persson

IPC: A61K31/445 ,  C07D401/12

CPC classification number: C07D401/12

Abstract: Formula (I) wherein R1 is a (2-4C)alkyl and is substituted by two or more fluorine groups and R2 is methyl or ethyl, or a pharmaceutically acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by metalloproteinase enzymes.

Abstract translation: 式（I）其中R1是（2-4C）烷基并被两个或更多个氟基取代，R2是甲基或乙基，或其药学上可接受的盐; 其制备方法，含有它们的药物组合物及其在治疗由金属蛋白酶介导的疾病或医学病症中的用途。