公开(公告)号：US20100297156A1

公开(公告)日：2010-11-25

申请号：US12519253

申请日：2007-12-20

Applicant: Gary David Ainge ,  Bryce Malcolm Buddle ,  Michel Denis ,  Robyn Louise Wright ,  Darren Gibson ,  Ahivali Ashwin Gulab ,  David Samual Larsen ,  Gavin Frank Painter ,  Natalie Anne Parlane

Inventor： Gary David Ainge ,  Bryce Malcolm Buddle ,  Michel Denis ,  Robyn Louise Wright ,  Darren Gibson ,  Ahivali Ashwin Gulab ,  David Samual Larsen ,  Gavin Frank Painter ,  Natalie Anne Parlane

IPC: A61K31/7034 ,  C07H15/207 ,  A61K39/00 ,  A61P31/00 ,  A61P37/08 ,  A61P35/00 ,  A61P31/04 ,  A61P31/06 ,  A61P17/00 ,  A61P17/08

CPC classification number: C07H15/04 ,  A61K39/39 ,  A61K2039/55511 ,  C07H15/20

Abstract: The invention relates to compounds which are immunomodulatory compounds and, in particular, can induce IL-12 secretion. The invention also relates to compositions containing the compounds, precursors, and prodrugs of these compounds, use of these compounds as adjuvants in combination with vaccines, and use of these compounds for treatment of diseases or conditions relating to infection, atopic disorders, or cancer.

Abstract translation: 本发明涉及作为免疫调节化合物的化合物，特别是可以诱导IL-12分泌。 本发明还涉及包含这些化合物的化合物，前体和前药的组合物，这些化合物作为佐剂与疫苗的组合的使用，以及这些化合物用于治疗与感染，特应性障碍或癌症有关的疾病或病症的用途。