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![Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors](/abs-image/US/2016/02/23/US09266891B2/abs.jpg.150x150.jpg)
1.发明授权Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors 有权取代的[1,2,4]三唑并[4,3-A]吡嗪是BRD4抑制剂公开(公告)号：US09266891B2
公开(公告)日：2016-02-23
申请号：US14076510
申请日：2013-11-11
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/501 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/32 , C07D519/00
CPC分类号： A61K31/4985 , A61K31/501 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/32 , C07D487/04 , C07D519/00
摘要： Disclosed are compounds of the formula (I) wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 公开了式（I）的化合物，其中基团R 1至R 3具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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公开(公告)号：US20140135336A1
公开(公告)日：2014-05-15
申请号：US14076507
申请日：2013-11-11
申请人： Harald ENGELHARDT , Davide GIANNI , Dirk KESSLER , Ulrich REISER , Christian SMETHURST , Andreas STEFFEN
发明人： Harald ENGELHARDT , Davide GIANNI , Dirk KESSLER , Ulrich REISER , Christian SMETHURST , Andreas STEFFEN
IPC分类号： C07D487/04 , A61K45/06 , A61K31/5025
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , A61K2300/00
摘要： Disclosed are compounds of general formula (I) wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 公开了通式（I）的化合物，其中基团R 1至R 3具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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公开(公告)号：US09422290B2
公开(公告)日：2016-08-23
申请号：US14076507
申请日：2013-11-11
申请人： Harald Engelhardt , Davide Gianni , Dirk Kessler , Ulrich Reiser , Christian Smethurst , Andreas Steffen
发明人： Harald Engelhardt , Davide Gianni , Dirk Kessler , Ulrich Reiser , Christian Smethurst , Andreas Steffen
IPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , A61K2300/00
摘要： Disclosed are compounds of general formula (I) wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 公开了通式（I）的化合物，其中基团R 1至R 3具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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公开(公告)号：US20140296229A1
公开(公告)日：2014-10-02
申请号：US14225484
申请日：2014-03-26
IPC分类号： C07D498/04 , C07D413/14 , C07D413/04
CPC分类号： C07D498/04 , C07D413/04 , C07D413/14
摘要： The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4, A1 and A2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 本发明包括通式（I）的化合物，其中基团R1至R4，A1和A2具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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公开(公告)号：US09102684B2
公开(公告)日：2015-08-11
申请号：US14225484
申请日：2014-03-26
IPC分类号： C07D413/04 , C07D413/14 , C07D498/04
CPC分类号： C07D498/04 , C07D413/04 , C07D413/14
摘要： The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4, A1 and A2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 本发明包括通式（I）的化合物，其中基团R1至R4，A1和A2具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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公开(公告)号：US20140296230A1
公开(公告)日：2014-10-02
申请号：US14225486
申请日：2014-03-26
IPC分类号： C07D471/04 , C07D413/14 , C07D413/04
CPC分类号： C07D471/04 , C07D413/04 , C07D413/14
摘要： The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4 and A1 to A5 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 本发明包括通式（I）的化合物，其中基团R1至R4和A1至A5具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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公开(公告)号：US09199988B2
公开(公告)日：2015-12-01
申请号：US14225486
申请日：2014-03-26
IPC分类号： C07D471/04 , C07D413/04 , C07D413/14
CPC分类号： C07D471/04 , C07D413/04 , C07D413/14
摘要： The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4 and A1 to A5 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 本发明包括通式（I）的化合物，其中基团R1至R4和A1至A5具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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公开(公告)号：US20140142098A1
公开(公告)日：2014-05-22
申请号：US14076510
申请日：2013-11-11
IPC分类号： C07D487/04 , C07D473/32 , A61K31/501 , A61K45/06 , A61K31/52 , A61K31/4985 , A61K31/5377
CPC分类号： A61K31/4985 , A61K31/501 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/32 , C07D487/04 , C07D519/00
摘要： Disclosed are compounds of the formula (I) wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
摘要翻译： 公开了式（I）的化合物，其中基团R 1至R 3具有权利要求书和说明书中给出的含义。 本发明的化合物适用于治疗特征在于过量或异常细胞增殖的药物，其含有这些化合物及其作为药物的用途。
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