摘要:
The present invention encompasses compounds of general Formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要:
The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要:
The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要:
A computer-implemented method for normalizing data-loss-prevention categorization information, at least a portion of the method being performed by a computing system comprising at least one processor, may identify a data object at a first time. The method may apply a first version of a set of data-loss-prevention rules to the data object to determine a set of categorizations of the data object. The method may distinguish a set of content-based categorizations in the set of categorizations from a set of context-based categorizations in the set of categorizations. The method may apply, based on the set of categorizations, a first data-loss-prevention policy to the data object. The method may identify the data object at a second time, and apply, based on the set of content-based categorizations, a second data-loss-prevention policy to the data object. Various other methods, systems, and computer-readable media are also disclosed.
摘要:
The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.
摘要:
Techniques for providing access to databases from handheld devices are disclosed. Techniques can be used to implement a database system. The database system provides a graphical user interface which can be displayed on handheld devices. This allows users of handheld devices to conveniently by interacting with the graphical user interface. As will be appreciated, the user can access the database to perform a variety of operations. Moreover, the user can perform these operations without having to write programs and virtually in real time. Thus, the user can conveniently access the database and be provided with up-to-date information. In addition, the user can be provided with hyperlinks which allow the user to conveniently perform various tasks without having to switch between different operation modes.
摘要:
The current invention restates substituted indole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted indole nucleosides can be used as labeling reagents for the facile preparation of e.g. optimized hybridization probes, Taqman-probes, or molecular beacon probes.
摘要:
The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is any organic substituent.
摘要:
A method and apparatus for classifying behavior of an application based on its data access pattern is described. In one embodiment, the method includes monitoring file access events associated with an application, and determining whether at least one of the file access events indicates the application's attempt to manipulate data of a file. If at least one file access event indicates the application's attempt to manipulate the data within the file, then at least one action is caused to be performed.
摘要:
The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is any organic substituent.