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公开(公告)号：US20200023147A1
公开(公告)日：2020-01-23
申请号：US16338311
申请日：2017-09-29
发明人： Brendan O?Flaherty , Johann Lipman , John Fraser , Shaun Gregory
IPC分类号： A61M15/00
摘要： A delivery device for use in administering a dry powder to a biological subject's airway is provided. The device comprises (a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; and (b) one or more cantilever structures located within the housing. Vibration of the one or more cantilever structures facilitates entry of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. Also provided is a container for releasably storing a particulate composition, the container comprising a shell sealed by a seal in which the particulate composition is stored, wherein a puncturing device for rupturing the seal to release the particulate composition is housed within the shell. Further provided are associated methods for administering dry powder using the delivery device and/or container.
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公开(公告)号：US11247001B2
公开(公告)日：2022-02-15
申请号：US16338311
申请日：2017-09-29
发明人： Brendan O'Flaherty , Johann Lipman , John Fraser , Shaun Gregory
IPC分类号： A61M15/00
摘要： A delivery device for use in administering a dry powder to a biological subject's airway is provided. The device comprises (a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; and (b) one or more cantilever structures located within the housing. Vibration of the one or more cantilever structures facilitates entry of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. Also provided is a container for releasably storing a particulate composition, the container comprising a shell sealed by a seal in which the particulate composition is stored, wherein a puncturing device for rupturing the seal to release the particulate composition is housed within the shell. Further provided are associated methods for administering dry powder using the delivery device and/or container.
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公开(公告)号：US12109356B2
公开(公告)日：2024-10-08
申请号：US18239551
申请日：2023-08-29
IPC分类号： A61M15/00
CPC分类号： A61M15/0041 , A61M15/0008 , A61M15/0025 , A61M15/0035 , A61M2202/064 , A61M2205/273
摘要： The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.
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公开(公告)号：US12029709B2
公开(公告)日：2024-07-09
申请号：US17886124
申请日：2022-08-11
发明人： John Fraser , Sean Mark Dalziel , Teresa Iley , Jonathan Brazier , Patrick Joseph Lynch , John Fredatovich , Benjamin Barnaby Trout
IPC分类号： A61K31/137 , A61K9/00 , A61K47/26
CPC分类号： A61K31/137 , A61K9/0075 , A61K47/26
摘要： The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.
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公开(公告)号：US20240050382A1
公开(公告)日：2024-02-15
申请号：US17886124
申请日：2022-08-11
发明人： John Fraser , Sean Mark Dalziel , Teresa Iley , Jonathan Brazier , Patrick Joseph Lynch , John Fredatovich , Benjamin Barnaby Trout
IPC分类号： A61K31/137 , A61K9/00 , A61K47/26
CPC分类号： A61K31/137 , A61K9/0075 , A61K47/26
摘要： The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.
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公开(公告)号：US20220379052A1
公开(公告)日：2022-12-01
申请号：US17886211
申请日：2022-08-11
IPC分类号： A61M15/00
摘要： The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.
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公开(公告)号：US20220305222A1
公开(公告)日：2022-09-29
申请号：US17619190
申请日：2020-06-23
IPC分类号： A61M15/00
摘要： The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.
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公开(公告)号：US20240342117A1
公开(公告)日：2024-10-17
申请号：US18672318
申请日：2024-05-23
发明人： John Fraser , Sean Dalziel , Teresa Iley , Jonathan Brazier , Patrick Joseph Lynch , John Fredatovich , Benjamin Barnaby Trout
IPC分类号： A61K31/137 , A61K9/00 , A61K47/26
CPC分类号： A61K31/137 , A61K9/0075 , A61K47/26
摘要： The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.
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公开(公告)号：US20240058555A1
公开(公告)日：2024-02-22
申请号：US18239551
申请日：2023-08-29
IPC分类号： A61M15/00
CPC分类号： A61M15/0041 , A61M15/0025 , A61M15/0008 , A61M15/0035 , A61M2202/064
摘要： The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.
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公开(公告)号：US20230364362A1
公开(公告)日：2023-11-16
申请号：US18214915
申请日：2023-06-27
IPC分类号： A61M15/00
CPC分类号： A61M15/0035 , A61M15/0008 , A61M2202/064
摘要： The present disclosure provides for a respiratory delivery device. Particularly, the disclosure provides for a delivery device for use in administering a particulate medicament to a subject's airway and lungs via inhalation. The delivery device may be suitable for emergency medicine for the delivery of active pharmaceutical ingredients including epinephrine.
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