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公开(公告)号:US20120328513A1
公开(公告)日:2012-12-27
申请号:US13528602
申请日:2012-06-20
申请人: Debbie Law , Kurt Gish
发明人: Debbie Law , Kurt Gish
CPC分类号: C07K16/30 , A61K39/0011 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , C07K14/4748 , C07K16/3069
摘要: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
摘要翻译: 本文描述了可用于诊断和治疗癌症的方法和组合物。
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公开(公告)号:US20100074841A1
公开(公告)日:2010-03-25
申请号:US12622298
申请日:2009-11-19
申请人: Debbie Law , Kurt C. Gish , Richard Murray , Patricia Culp
发明人: Debbie Law , Kurt C. Gish , Richard Murray , Patricia Culp
IPC分类号: A61K51/00 , A61K39/395 , C07K16/46 , C07K16/30 , C12N5/16
CPC分类号: C07K16/30 , A61K39/0011 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , C07K14/4748 , C07K16/3069
摘要: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
摘要翻译: 本文描述了可用于诊断和治疗癌症的方法和组合物。
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公开(公告)号:US20090246852A1
公开(公告)日:2009-10-01
申请号:US12397026
申请日:2009-03-03
申请人: Marna Williams , J. Yun Tso , Nicholas F. Landolfi , David B. Powers , Robert B. DuBridge , Debbie Law , Gao Liu
发明人: Marna Williams , J. Yun Tso , Nicholas F. Landolfi , David B. Powers , Robert B. DuBridge , Debbie Law , Gao Liu
CPC分类号: C07K16/2803 , A61K2039/505 , C07K14/70503 , C07K16/2806 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists.
摘要翻译: 本发明涉及CS1的结合并中和CS1的至少一种生物学活性的拮抗剂。 本发明还包括含有此类抗体或其抗原结合片段的药物组合物。 本发明还提供了在有需要的受试者中预防或治疗疾病状态(包括自身免疫疾病和癌症)的方法,包括向所述受试者施用有效量的这种拮抗剂。
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公开(公告)号:US07824678B2
公开(公告)日:2010-11-02
申请号:US11837337
申请日:2007-08-10
申请人: Vinay Bhaskar , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
发明人: Vinay Bhaskar , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
IPC分类号: A61K39/395
CPC分类号: C07K16/3069 , A61K47/6817 , A61K47/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/77
摘要: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
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公开(公告)号:US07807163B2
公开(公告)日:2010-10-05
申请号:US12203868
申请日:2008-09-03
申请人: Debbie Law , Qi Wang , Robert DuBridge , Vinay Bhaskar
发明人: Debbie Law , Qi Wang , Robert DuBridge , Vinay Bhaskar
IPC分类号: A61K39/00
CPC分类号: C07K14/705 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/77 , C07K2319/30 , A61K2300/00
摘要: GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types.
摘要翻译: 提供GPR64抗体组合物。 这些抗体可用于诊断或治疗癌症,特别是卵巢癌,尤因氏肉瘤,子宫癌和其他表达GPR64的肿瘤类型。
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公开(公告)号:US07785816B2
公开(公告)日:2010-08-31
申请号:US11837333
申请日:2007-08-10
申请人: Vinay Bhaskar , Agustin de la Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
发明人: Vinay Bhaskar , Agustin de la Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
IPC分类号: G01N33/574
CPC分类号: C07K16/3069 , A61K47/6817 , A61K47/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/77
摘要: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
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公开(公告)号:US07674883B2
公开(公告)日:2010-03-09
申请号:US11855073
申请日:2007-09-13
申请人: Vinay Bhaskar , Agustin de la Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
发明人: Vinay Bhaskar , Agustin de la Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
CPC分类号: C07K16/3069 , A61K47/6817 , A61K47/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/77
摘要: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
摘要翻译: 本文描述了可用于诊断和治疗癌症的方法和组合物。
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公开(公告)号:US20090117036A1
公开(公告)日:2009-05-07
申请号:US12203868
申请日:2008-09-03
申请人: Debbie Law , Qi Wang , Robert BuBridge , Vinay Bhaskar
发明人: Debbie Law , Qi Wang , Robert BuBridge , Vinay Bhaskar
IPC分类号: A61K51/00 , C07K16/18 , C12N5/06 , A61K39/395
CPC分类号: C07K14/705 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/77 , C07K2319/30 , A61K2300/00
摘要: GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types.
摘要翻译: 提供GPR64抗体组合物。 这些抗体可用于诊断或治疗癌症,特别是卵巢癌,尤因氏肉瘤,子宫癌和其他表达GPR64的肿瘤类型。
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公开(公告)号:US20080107642A1
公开(公告)日:2008-05-08
申请号:US11852155
申请日:2007-09-07
申请人: Debbie Law , Qi Wang , Robert DuBridge , Vinay Bhaskar
发明人: Debbie Law , Qi Wang , Robert DuBridge , Vinay Bhaskar
IPC分类号: A61K39/395 , C12N5/06 , A61P43/00 , C07K16/18
CPC分类号: C07K14/705 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/77 , C07K2319/30 , A61K2300/00
摘要: GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types.
摘要翻译: 提供GPR64抗体组合物。 这些抗体可用于诊断或治疗癌症,特别是卵巢癌,尤因氏肉瘤,子宫癌和其他表达GPR64的肿瘤类型。
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公开(公告)号:US20050002939A1
公开(公告)日:2005-01-06
申请号:US10738021
申请日:2003-12-16
申请人: Albert Zlotnik , Debbie Law , Richard Murray
发明人: Albert Zlotnik , Debbie Law , Richard Murray
IPC分类号: A61K39/395 , C07K16/28 , G01N20060101
CPC分类号: C07K16/2866 , A61K2039/505
摘要: The invention relates to the identification of chemokine receptors associated with cancers and other diseases. The invention also provides for the use of antagonists of the CXCR4 protein in diagnosis and therapy of proliferative disease.
摘要翻译: 本发明涉及与癌症和其他疾病相关的趋化因子受体的鉴定。 本发明还提供CXCR4蛋白拮抗剂在增殖性疾病的诊断和治疗中的用途。
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