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公开(公告)号：US20100292269A1
公开(公告)日：2010-11-18
申请号：US12825197
申请日：2010-06-28
申请人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James Jaquith , Alain Laurent , Delphine Labit
发明人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James Jaquith , Alain Laurent , Delphine Labit
IPC分类号： A61K31/4725 , C12N5/02 , A61K31/4709 , A61K31/4439 , A61K31/4178 , A61K31/40
CPC分类号： C07D207/09 , C07K5/06026 , C07K5/06034 , C07K5/06069
摘要： The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R1, R1a, R2, R2a, R3, A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer
摘要翻译： 本发明涉及由式I表示的吡咯烷化合物的异构体，对映异构体，非对映异构体或互变异构体：其中取代基R1，R1a，R2，R2a，R3，A和Q如本文所定义; 或其前药或其盐，并且其结合IAP BIR结构域。 特别地，这些化合物可用于治疗增殖性疾病如癌症
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公开(公告)号：US20060264379A1
公开(公告)日：2006-11-23
申请号：US11434166
申请日：2006-05-16
申请人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James Jaquith , Alain Laurent , Delphine Labit
发明人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James Jaquith , Alain Laurent , Delphine Labit
CPC分类号： C07D207/09 , C07K5/06026 , C07K5/06034 , C07K5/06069
摘要： The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R1, R1a, R2, R2a, R3, A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer
摘要翻译： 本发明涉及由式I表示的吡咯烷化合物的异构体，对映体，非对映异构体或互变异构体：其中取代基R 1，R 1a， R 2，R 2，R 3，A和Q在本文中定义; 或其前药或其盐，并且其结合IAP BIR结构域。 特别地，这些化合物可用于治疗增殖性疾病如癌症
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公开(公告)号：US08575113B2
公开(公告)日：2013-11-05
申请号：US12825197
申请日：2010-06-28
申请人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James B. Jaquith , Alain Laurent , Delphine Labit
发明人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James B. Jaquith , Alain Laurent , Delphine Labit
CPC分类号： C07D207/09 , C07K5/06026 , C07K5/06034 , C07K5/06069
摘要： The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R1, R1a, R2, R2a, R3, A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer.
摘要翻译： 本发明涉及由式I表示的吡咯烷化合物的异构体，对映异构体，非对映异构体或互变异构体：其中取代基R1，R1a，R2，R2a，R3，A和Q如本文所定义; 或其前药或其盐，并且其结合IAP BIR结构域。 特别地，这些化合物可用于治疗增殖性疾病如癌症。
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公开(公告)号：US07772177B2
公开(公告)日：2010-08-10
申请号：US11434166
申请日：2006-05-16
申请人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James Jaquith , Alain Laurent , Delphine Labit
发明人： Scott Jarvis , Alain Boudreault , Patrick Bureau , James Jaquith , Alain Laurent , Delphine Labit
IPC分类号： C07K5/06
CPC分类号： C07D207/09 , C07K5/06026 , C07K5/06034 , C07K5/06069
摘要： The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R1, R1a, R2, R2a, R3, A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer.
摘要翻译： 本发明涉及由式I表示的吡咯烷化合物的异构体，对映异构体，非对映异构体或互变异构体：其中取代基R1，R1a，R2，R2a，R3，A和Q如本文所定义; 或其前药或其盐，并且其结合IAP BIR结构域。 特别地，这些化合物可用于治疗增殖性疾病如癌症。
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