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公开(公告)号:US20080131893A1
公开(公告)日:2008-06-05
申请号:US11849090
申请日:2007-08-31
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要: This document relates to methods and materials involved in predicting Parkinson's disease. For example, methods for assessing the genotype of a human to determine whether or not the human has an increased susceptibility of developing Parkinson's disease are provided. In addition, diagnostic devices containing probe or primer collections designed to detect the genotype of a human, thereby providing the ability to assess the human for increased susceptibility to develop Parkinson's disease, also are provided.
摘要翻译: 本文件涉及预测帕金森病的方法和材料。 例如,提供了用于评估人的基因型以确定人是否具有增加的发展为帕金森病的易感性的方法。 此外,还提供了包含设计用于检测人的基因型的探针或引物集合的诊断装置,从而提供评估人类增加的发展帕金森病易感性的能力。
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公开(公告)号:US20110092565A1
公开(公告)日:2011-04-21
申请号:US12416140
申请日:2009-03-31
IPC分类号: A61K31/7105 , A61P25/28
CPC分类号: C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3517 , C12N2310/3521
摘要: Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti-SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.
摘要翻译: 本发明特征的方面涉及用于抑制α-突触核蛋白(SNCA)基因表达的组合物和方法,例如用于治疗神经变性疾病。 本文特征的针对SNCA基因的抗SNCA试剂可以被修饰以改变有利于神经细胞的分布。
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