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![HETEROARYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/abs-image/US/2010/04/15/US20100093756A1/abs.jpg.150x150.jpg)
1.发明申请HETEROARYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 审中-公开取代噻吩并[2,3-d]吡啶并用作腺苷A2a受体拮抗剂公开(公告)号：US20100093756A1
公开(公告)日：2010-04-15
申请号：US12499370
申请日：2009-07-08
Applicant: J. Kent Berbay , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
Inventor： J. Kent Berbay , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
IPC: A61K31/497 , C07D495/02 , A61K31/519 , A61P25/00
CPC classification number: C07D495/04
Abstract: This invention relates to a novel thieno[2,3-d]pyrimidine, Z, and its therapeutic and prophylactic uses, wherein X, R1 and R2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.
Abstract translation: 本发明涉及一种新颖的噻吩并[2,3-d]嘧啶Z及其治疗和预防用途，其中X，R 1和R 2在本说明书中定义。 治疗和/或预防的疾病包括帕金森病。
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公开(公告)号：US09045389B2
公开(公告)日：2015-06-02
申请号：US13478568
申请日：2012-05-23
Applicant: Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
Inventor： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC: A61K31/166 , C07C229/52 , C07C237/36
CPC classification number: C07C237/36
Abstract: The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
Abstract translation: 本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。
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![HETEROCYCLYL AND CYCLOALKYL SUBSTITUTED THIENO[2,3 d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/abs-image/US/2010/04/15/US20100093723A1/abs.jpg.150x150.jpg)
3.发明申请HETEROCYCLYL AND CYCLOALKYL SUBSTITUTED THIENO[2,3 d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 审中-公开环己基和环己基取代的噻吩并[2,3 d]吡啶并且作为腺苷A2a受体拮抗剂使用公开(公告)号：US20100093723A1
公开(公告)日：2010-04-15
申请号：US12499466
申请日：2009-07-08
Applicant: J. Kent Barbay , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
Inventor： J. Kent Barbay , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
IPC: A61K31/5377 , C07D413/14 , C07D491/04 , A61K31/519 , A61P25/28
CPC classification number: C07D495/04
Abstract: This invention relates to a novel thieno[2,3-d]pyrimidine, Z, and its therapeutic and prophylactic uses, wherein X, R1 and R2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.
Abstract translation: 本发明涉及一种新颖的噻吩并[2,3-d]嘧啶Z及其治疗和预防用途，其中X，R 1和R 2在本说明书中定义。 治疗和/或预防的疾病包括帕金森病。
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![AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/abs-image/US/2010/04/15/US20100093714A1/abs.jpg.150x150.jpg)
4.发明申请AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 审中-公开噻吩并[2,3-d]吡啶的氨基酸及其作为腺苷A2a受体拮抗剂的用途公开(公告)号：US20100093714A1
公开(公告)日：2010-04-15
申请号：US12479209
申请日：2009-06-05
Applicant: Devraj CHAKRAVARTY , Brian Christopher SHOOK
Inventor： Devraj CHAKRAVARTY , Brian Christopher SHOOK
IPC: A61K31/519 , C07D495/04 , A61K31/5377 , A61K31/541 , A61P25/00
CPC classification number: C07D495/04
Abstract: This invention relates to a novel thieno[2,3-d]pyrimidine, A, and its therapeutic and prophylactic uses, wherein R1 and R2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.
Abstract translation: 本发明涉及一种新颖的噻吩并[2,3-d]嘧啶A及其治疗和预防用途，其中R1和R2在说明书中定义。 治疗和/或预防的疾病包括帕金森病。
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![AMINES AND SULFOXIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/abs-image/US/2010/04/15/US20100093764A1/abs.jpg.150x150.jpg)
5.发明申请AMINES AND SULFOXIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 审中-公开噻吩并[2,3-d]吡啶的氨基和硫代磷酸酯及其作为腺苷A2a受体拮抗剂的用途公开(公告)号：US20100093764A1
公开(公告)日：2010-04-15
申请号：US12499483
申请日：2009-07-08
Applicant: Devraj Chakravarty , Brian Christopher Shook
Inventor： Devraj Chakravarty , Brian Christopher Shook
IPC: A61K31/519 , C07D491/04 , A61P25/28
CPC classification number: C07D495/04
Abstract: This invention relates to a novel thieno[2,3-d]pyrimidine, A, and its therapeutic and prophylactic uses, wherein R1 and R2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.
Abstract translation: 本发明涉及一种新颖的噻吩并[2,3-d]嘧啶A及其治疗和预防用途，其中R1和R2在本说明书中定义。 治疗和/或预防的疾病包括帕金森病。
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Patent Agency Ranking
![PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/abs-image/US/2010/04/15/US20100093763A1/abs.jpg.150x150.jpg)
6.发明申请PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 审中-公开苯基取代的噻吩并[2,3-d]嘧啶并用作腺苷A2a受体拮抗剂公开(公告)号：US20100093763A1
公开(公告)日：2010-04-15
申请号：US12499357
申请日：2009-07-08
Applicant: J. Kent Barbay , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
Inventor： J. Kent Barbay , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
IPC: A61K31/519 , C07D491/04 , A61P25/28
CPC classification number: C07D495/04
Abstract: This invention relates to a novel thieno[2,3-d]pyrimidine, Z, and its therapeutic and prophylactic uses, wherein R1 and R2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.
Abstract translation: 本发明涉及一种新颖的噻吩并[2,3-d]嘧啶Z及其治疗和预防用途，其中R1和R2在本说明书中定义。 治疗和/或预防的疾病包括帕金森病。
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![HETEROARYL AND PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/abs-image/US/2010/04/15/US20100093722A1/abs.jpg.150x150.jpg)
7.发明申请HETEROARYL AND PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 审中-公开取代三苯并[2,3-d]嘧啶并用作腺苷A2a受体拮抗剂公开(公告)号：US20100093722A1
公开(公告)日：2010-04-15
申请号：US12499342
申请日：2009-07-08
Applicant: J. Kent BARBAY , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
Inventor： J. Kent BARBAY , Devraj Chakravarty , Kristi Leonard , Brian Christopher Shook , Aihua Wang
IPC: A61K31/519 , C07D495/04 , A61K31/5377 , A61P25/00
CPC classification number: C07D495/04
Abstract: This invention relates to a novel thieno[2,3-d]pyrimidine, Z, and its therapeutic and prophylactic uses, wherein R1 and R2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.
Abstract translation: 本发明涉及一种新颖的噻吩并[2,3-d]嘧啶Z及其治疗和预防用途，其中R1和R2在本说明书中定义。 治疗和/或预防的疾病包括帕金森病。
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8.发明授权Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists 有权可用作胰高血糖素受体拮抗剂的吡啶酰胺 - 丙酸衍生物公开(公告)号：US08748624B2
公开(公告)日：2014-06-10
申请号：US13478534
申请日：2012-05-23
Applicant: Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
Inventor： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
IPC: A61K31/44 , C07D211/70
CPC classification number: C07D213/81
Abstract: The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
Abstract translation: 本发明涉及吡啶甲酰 - 丙酸衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体而改善的病症和病症的用途，包括例如代谢性疾病如II型糖尿病 和肥胖。
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公开(公告)号：US20120302641A1
公开(公告)日：2012-11-29
申请号：US13478568
申请日：2012-05-23
Applicant: Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
Inventor： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC: A61K31/197 , A61P13/12 , A61P3/04 , C07C237/36 , A61P3/10
CPC classification number: C07C237/36
Abstract: The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
Abstract translation: 本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。
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10.发明申请PICOLINAMIDO-PROPANOIC ACID DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS 有权作为GLUCAGON受体拮抗剂有用的PICOLINAMIDO-丙二酸衍生物公开(公告)号：US20120302610A1
公开(公告)日：2012-11-29
申请号：US13478534
申请日：2012-05-23
Applicant: Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
Inventor： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
IPC: A61K31/4418 , A61P13/12 , A61P3/04 , C07D213/81 , A61P3/10
CPC classification number: C07D213/81
Abstract: The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
Abstract translation: 本发明涉及吡啶甲酰 - 丙酸衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体而改善的病症和病症的用途，包括例如代谢性疾病如II型糖尿病 和肥胖。
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