公开(公告)号：US20060173214A1

公开(公告)日：2006-08-03

申请号：US10540556

申请日：2002-12-26

Applicant: Sushil Dubey ,  Dharmeshkumar Patel ,  Dhimant Patel ,  Mahesh Rupapara ,  Virendra Agarwal ,  Kanwal Pandita ,  Pankaj Patel

Inventor： Sushil Dubey ,  Dharmeshkumar Patel ,  Dhimant Patel ,  Mahesh Rupapara ,  Virendra Agarwal ,  Kanwal Pandita ,  Pankaj Patel

IPC: C07C303/02

CPC classification number: C07C303/44 ,  C07B2200/07 ,  C07C303/40 ,  C07C311/37

Abstract: The invention relates to a process for the manufacture of optically pure (R) or (S)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide with D-i.e. (2S, 3S) or L-i.e. (2R, 3R)-tartaric acid to form a mixture of diastereomeric salts, separating the diastereomeric salts by fractional crystallization in a mixture of solvent systems and at the specified temperature range and contacting the individual salts so separated with a base to provide said R-(−)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide or S-(+)-5-(2-amino propyl)-2-methoxybenzenesulfonamide.

Abstract translation: 本发明涉及用D-制备光学纯的（R）或（S）-5-（2-氨基丙基）-2-甲氧基苯磺酰胺的方法。 （2S，3S）或L - 即。 （2R，3R） - 酒石酸形成非对映异构盐的混合物，通过在溶剂体系和规定的温度范围的混合物中分级结晶分离非对映异构体盐，并使如此分离的各个盐与碱接触，以提供所述R- （ - ） - 5-（2-氨基丙基）-2-甲氧基苯磺酰胺或S - （+） - 5-（2-氨基丙基）-2-甲氧基苯磺酰胺。

公开(公告)号：US20180362927A1

公开(公告)日：2018-12-20

申请号：US16060651

申请日：2016-12-08

Applicant: Bryce R. BKAZAR ,  Dharmeshkumar PATEL ,  Beau R. WEBBER ,  Jakub TOLAR ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Bruce R. BLAZAR ,  Dharmeshkumar PATEL ,  Beau R. WEBBER ,  Jakub TOLAR

IPC: C12N5/0783 ,  C12N5/074

Abstract: Induced pluripotent stem cells (iPSCs) derived from a T cell of a T cell subset. T cells derived from iPSCs derived from a T cell. Methods of deriving iPSCs from a T cell. Methods of deriving T cells from iPSCs including deriving a T cell of a T cell subset from an iPSC. Methods of engineering chimeric antigen receptor (CAR)-expressing or T cell receptor (TCR)-expressing iPSC. Methods of administering T cells derived using the methods disclosed. Induced pluripotent stem cell lines derived from T cells, methods of deriving induced pluripotent stem cell lines, and methods of deriving T cells from induced pluripotent stem cell lines.