公开(公告)号：US20150301042A1

公开(公告)日：2015-10-22

申请号：US14557097

申请日：2014-12-01

申请人： Diagnotic Hybrids, Inc.

发明人： James L. Brown

IPC分类号： G01N33/564

CPC分类号： G01N33/564 ,  C07K14/721 ,  C07K2319/61 ,  G01N2333/726 ,  G01N2800/24 ,  Y10S435/80

摘要： The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.

摘要翻译： 本发明提供了用于诊断和治疗自身免疫疾病的方法和组合物。 特别地，本发明提供了用于诊断和治疗格雷夫斯病的改进方法和组合物。 本发明的方法不仅避免了对放射性的需要，而且比传统上用于诊断格雷夫斯病的方法简单，经济和快速，而且改进了以前基于荧光素酶的自身抗体检测的灵敏度和检测能力 测定。