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    Methods Of Using Chimeric Receptors To Identify Autoimmune Disease
    2.
    发明申请
    Methods Of Using Chimeric Receptors To Identify Autoimmune Disease 有权
    使用嵌合受体鉴定自身免疫性疾病的方法

    公开(公告)号：US20150301042A1

    公开(公告)日：2015-10-22

    申请号：US14557097

    申请日：2014-12-01

    申请人： Diagnotic Hybrids, Inc.

    发明人： James L. Brown

    IPC分类号： G01N33/564

    CPC分类号： G01N33/564 ,  C07K14/721 ,  C07K2319/61 ,  G01N2333/726 ,  G01N2800/24 ,  Y10S435/80

    摘要： The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.

    摘要翻译： 本发明提供了用于诊断和治疗自身免疫疾病的方法和组合物。 特别地，本发明提供了用于诊断和治疗格雷夫斯病的改进方法和组合物。 本发明的方法不仅避免了对放射性的需要，而且比传统上用于诊断格雷夫斯病的方法简单，经济和快速，而且改进了以前基于荧光素酶的自身抗体检测的灵敏度和检测能力 测定。

    Methods Of Using Chimeric Receptors to Identify Autoimmune Disease
    3.
    发明申请
    Methods Of Using Chimeric Receptors to Identify Autoimmune Disease 有权
    使用嵌合受体鉴定自身免疫性疾病的方法

    公开(公告)号：US20130059312A1

    公开(公告)日：2013-03-07

    申请号：US13611819

    申请日：2012-09-12

    申请人： James L. Brown

    发明人： James L. Brown

    IPC分类号： C07K14/72 ,  C12Q1/68 ,  C12N5/10 ,  C12N15/12 ,  C12N15/85

    CPC分类号： G01N33/564 ,  C07K14/721 ,  C07K2319/61 ,  G01N2333/726 ,  G01N2800/24 ,  Y10S435/80

    摘要： The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.

    摘要翻译： 本发明提供了用于诊断和治疗自身免疫疾病的方法和组合物。 特别地，本发明提供了用于诊断和治疗格雷夫斯病的改进方法和组合物。 本发明的方法不仅避免了对放射性的需要，而且比传统上用于诊断格雷夫斯病的方法简单，经济和快速，而且改进了以前基于荧光素酶的自身抗体检测的灵敏度和检测能力 测定。

    Method for producing fats or oils
    5.
    发明授权
    Method for producing fats or oils 有权
    生产油脂的方法

    公开(公告)号：US07452702B2

    公开(公告)日：2008-11-18

    申请号：US10875532

    申请日：2004-06-25

    申请人： Immok Lee

    发明人： Immok Lee

    IPC分类号： C12P7/64 ,  C11B1/00

    CPC分类号： C11C3/10 ,  C12P7/62 ,  C12P7/6454 ,  Y10S435/80 ,  Y10S435/962

    摘要： The present invention is directed to improving productivity of an enzymatic method for making esterified, transesterified or interesterified products. Specifically, a method that can greatly improve the productivity of enzymatic transesterification or esterification by deodorization alone, or by deodorization and purification of the initial substrate to extend the useful life of the enzyme is disclosed.

    摘要翻译： 本发明旨在提高用于制备酯化，酯交换或酯交换产物的酶法的生产率。 具体地说，公开了一种可以通过单独除臭或通过除臭和纯化初始底物来大大提高酶酯交换或酯化的生产力以延长酶的使用寿命的方法。

    Isolation and purification of Clostridium botulinum toxins
    6.
    发明授权
    Isolation and purification of Clostridium botulinum toxins 失效
    肉毒杆菌毒素的分离和纯化

    公开(公告)号：US06818409B2

    公开(公告)日：2004-11-16

    申请号：US10137507

    申请日：2002-04-30

    申请人： Kenji Oguma

    发明人： Kenji Oguma

    IPC分类号： C07K1433

    CPC分类号： C07K14/33 ,  Y10S435/80 ,  Y10S435/82 ,  Y10S530/82

    摘要： A method for separating and purifying HA-positive progenitor toxin(s) (LL and/or L toxins) and HA-negative progenitor toxin (M toxin) from a Clostridium botulinum strain is provided. The method comprises applying a liquid containing both the HA-positive progenitor toxin(s) and the HA-negative progenitor toxin to a lactose column. Also provided is a method for separating and purifying neurotoxin (7S toxin) from HA-positive progenitor toxins, which comprises treating HA-positive progenitor toxins with an alkaline buffer and then applying the resulting liquid containing dissociated neurotoxin and non-toxic components to a lactose column. Activated pure HA-positive toxins (L and LL toxins) and neurotoxin are obtained by simple procedures.

    摘要翻译： 提供了从肉毒梭菌菌株分离和纯化HA阳性祖细胞毒素（LL和/或L毒素）和HA阴性祖细胞毒素（M毒素）的方法。 该方法包括将含有HA-阳性祖细胞毒素和HA-阴性祖细胞毒素的液体施用于乳糖柱。 还提供了用于从HA阳性祖细胞毒素分离和纯化神经毒素（7S毒素）的方法，其包括用碱性缓冲液处理HA阳性祖细胞毒素，然后将含有解离的神经毒素和无毒成分的所得液体施用于乳糖 柱。 通过简单的程序获得活化的纯HA-阳性毒素（L和LL毒素）和神经毒素。

    Non-toxigenic strain of Aspergillus oryzae and Aspergillus sojae for biocontrol of toxigenic fungi
    7.
    发明授权
    Non-toxigenic strain of Aspergillus oryzae and Aspergillus sojae for biocontrol of toxigenic fungi 失效
    无菌菌株的米曲霉和曲霉菌用于生物防治产毒真菌

    公开(公告)号：US6027724A

    公开(公告)日：2000-02-22

    申请号：US110132

    申请日：1998-07-06

    申请人： Joe W. Dorner ,  Bruce W. Horn ,  Richard J. Cole

    发明人： Joe W. Dorner ,  Bruce W. Horn ,  Richard J. Cole

    IPC分类号： A01N63/04 ,  A01N25/00 ,  A01N25/32 ,  A01N63/00 ,  C12N1/14 ,  D06M16/00

    CPC分类号： C12R1/66 ,  A01N63/04 ,  Y10S435/80 ,  Y10S435/911 ,  Y10S435/913 ,  Y10S435/915 ,  Y10S435/918

    摘要： Non-toxigenic strains of Aspergillus such as from the species Aspirgillus oryzae and Aspergillus sojae are useful fungal biocontrol agents for preventing toxin contamination in agricultural commodities, especially those for human consumption such as peanuts and corn. These strains do not produce aflatoxin, any bis-furan ring-containing intermediates of the aflatoxin biosynthetic pathway and cyclopiazonic acid. They are also useful for controlling toxin damage to crops such as cotton. The strains include Aspergillus strains NRRL 21368, NRRL 21369, NRRL 21882, NRRL 30038, NRRL 30039 and mixtures thereof.

    摘要翻译： 曲霉菌的非产毒菌株如来自米曲霉和曲霉属的菌株是有用的真菌生物防治剂，用于防止农产品中的毒素污染，特别是人们消费的毒素如花生和玉米。 这些菌株不产生黄曲霉毒素，黄曲霉毒素生物合成途径的任何含双呋喃环的中间体和环磷酸。 它们也可用于控制对棉花等作物的毒素损伤。 菌株包括曲霉菌株NRRL 21368，NRRL 21369，NRRL 21882，NRRL 30038，NRRL 30039及其混合物。

    Screening of microorganisms for bioremediation
    9.
    发明授权
    Screening of microorganisms for bioremediation 失效
    筛选微生物进行生物修复

    公开(公告)号：US5756304A

    公开(公告)日：1998-05-26

    申请号：US502050

    申请日：1995-07-14

    申请人： Stevan B. Jovanovich

    发明人： Stevan B. Jovanovich

    IPC分类号： C12Q1/04 ,  G01N35/00 ,  C12M1/00 ,  C12N1/00 ,  C12Q1/00

    CPC分类号： C12Q1/04 ,  G01N35/0099 ,  Y10S435/80 ,  Y10S435/821 ,  Y10S435/832 ,  Y10S435/839 ,  Y10S588/90 ,  Y10T436/11 ,  Y10T436/21

    摘要： The present invention is directed to the application of robotics to screen and optimize microorganisms for their bioremediation capabilities. In particular, the present invention provides methods to screen for the ability of microorganisms to metabolize particular compounds of interest in bioremediation applications. The present invention also provides a method for discovery of microorganisms useful for bioremediation and biomining, as well as other applications where microbial metabolism is useful for catalyzing chemical biotransformations.

    摘要翻译： 本发明涉及机器人的应用来筛选和优化微生物的生物修复能力。 特别地，本发明提供筛选生物修复应用中微生物代谢特定化合物的能力的方法。 本发明还提供用于发现可用于生物修复和生物学的微生物的方法，以及其中微生物代谢可用于催化化学生物转化的其它应用。

    Plant propagation system
    10.
    发明授权
    Plant propagation system 失效
    植物繁殖系统

    公开(公告)号：US5597731A

    公开(公告)日：1997-01-28

    申请号：US458988

    申请日：1995-06-02

    申请人： Roy E. Young ,  Jeffrey W. Adelberg

    发明人： Roy E. Young ,  Jeffrey W. Adelberg

    IPC分类号： A01H4/00 ,  C12M1/00 ,  C12M1/36 ,  C12M3/06 ,  C12M3/00 ,  A01G31/02

    CPC分类号： A01H4/005 ,  A01H4/001 ,  Y10S435/80 ,  Y10S435/809

    摘要： A plant propagation system and method are provided for promoting the growth of plant tissue into small plantlets. The plant propagation system includes sealed, semipermeable membrane vessels for completely enclosing plant material therein. The sealed vessels generally are translucent and permeable to gases and liquids while remaining impermeable to biological contaminates. Plant tissue originally extracted from a parent plant can be placed within the sealed vessels and grown heterotrophically. Once the plant material has developed the capability to photosynthesize, the sealed vessels can be transferred to a greenhouse environment for photoautotrophic growth. Once in a greenhouse environment, the sealed vessels are supported in trays and exposed to light, gases, water and a liquid nutrient solution for optimizing growth. A central controller can be included in order to automate the system for controlling the flow of fluids in and out of the vessel support trays while also monitoring system conditions. A disinfectant can also be circulated within the system for destroying biological contaminants in the tray and outside the sealed vessels for maintaining an aseptic environment.

    摘要翻译： 提供植物繁殖系统和方法，用于促进植物组织生长成小植株。 植物繁殖系统包括用于在其中完全包围植物材料的密封的半透膜膜容器。 密封容器通常是半透明的并且对气体和液体是可渗透的，同时对生物污染物仍然是不可渗透的。 最初从母本植物提取的植物组织可以放置在密封的容器内并且异养生长。 一旦植物材料开发出光合作用的能力，密封的容器可以转移到温室环境以进行光自养生长。 一旦在温室环境中，密封的容器支撑在托盘中并暴露于光，气体，水和液体营养液中以优化生长。 可以包括中央控制器以便自动化系统以控制流入和流出容器支撑盘的流体，同时还监视系统状况。 消毒剂也可以在系统内循环，以破坏托盘中的生物污染物和密封容器外部，以维持无菌环境。