公开(公告)号：US20070088248A1

公开(公告)日：2007-04-19

申请号：US11516462

申请日：2006-09-05

申请人： Gregory Glenn ,  Kyle Doerksen ,  Larry Ellingsworth ,  Diane Epperson ,  David Frerichs ,  Mervyn Hamer ,  Aaron Henningsgaard ,  Matthew Inouye ,  Adrian James ,  Jonathan Kaplan ,  John Lai ,  Robert Lister ,  David Lubensky ,  Peter MacDonald ,  Sally Madsen ,  Brian Mason ,  Christine McElhaney ,  Lionel Mohri ,  Anthony Pigliacampo ,  Gina Romero ,  Charles Steeves ,  Christina Villar ,  Jianmei Yu

发明人： Gregory Glenn ,  Kyle Doerksen ,  Larry Ellingsworth ,  Diane Epperson ,  David Frerichs ,  Mervyn Hamer ,  Aaron Henningsgaard ,  Matthew Inouye ,  Adrian James ,  Jonathan Kaplan ,  John Lai ,  Robert Lister ,  David Lubensky ,  Peter MacDonald ,  Sally Madsen ,  Brian Mason ,  Christine McElhaney ,  Lionel Mohri ,  Anthony Pigliacampo ,  Gina Romero ,  Charles Steeves ,  Christina Villar ,  Jianmei Yu

IPC分类号： A61B17/20

CPC分类号： A61B17/20 ,  A61B17/205 ,  A61B2017/00115 ,  A61B2017/00761 ,  A61B2090/065 ,  A61M35/006 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061

摘要： The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.

摘要翻译： 本发明提供用于破坏一层或多层皮肤的装置及其用于施用治疗剂例如抗原或药物的方法。 这些设备旨在破坏定义的皮肤区域。 限定的面积可以近似用于治疗剂（例如药物或疫苗）递送被设计为接触的贴剂或其它合适载体的区域。 示例性设备使用掩模来限定待破坏的区域。 其他设备通过旋转到位来破坏定义的区域。 对于使用固定在皮肤上的面罩的装置，本发明提供了通过首先将面罩固定在皮肤上然后破坏皮肤来破坏角质层的方法。 对于旋转装置，干扰构件被简单地放置在皮肤上并被致动以实现中断。