公开(公告)号：US08008330B2

公开(公告)日：2011-08-30

申请号：US12549947

申请日：2009-08-28

Applicant: TianLing Chen ,  Diane Greeley ,  John David Rothermel ,  Markus Wartmann ,  Jeanette Marjorie Wood

Inventor： TianLing Chen ,  Diane Greeley ,  John David Rothermel ,  Markus Wartmann ,  Jeanette Marjorie Wood

IPC: A61K31/427 ,  A61K31/28

CPC classification number: A61K31/663 ,  A61K31/427 ,  A61K31/502 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.

Abstract translation: 本发明涉及一种组合，其包含（a）二膦酸盐，铂化合物或血管保护性化合物和（b）式I的埃坡霉素衍生物，其中A表示O或NRN，其中RN为氢或低级烷基，R为氢或 低级烷基和Z是O或键，其中活性成分（a）和（b）在每种情况下以游离形式或以药学上可接受的盐和任选的至少一种药学上可接受的载体的形式存在 ，单独或顺序使用，特别是用于延缓进展或治疗增殖性疾病，特别是实体肿瘤疾病; 药物组合物，商业包装或包含这种组合的产品; 使用这种组合来制备用于延缓进展或治疗增殖性疾病的药物以及治疗温血动物的方法。

公开(公告)号：US20090318390A1

公开(公告)日：2009-12-24

申请号：US12549947

申请日：2009-08-28

Applicant: TianLing Chen ,  Diane Greeley ,  John David Rothermel ,  Markus Wartmann ,  Jeanette Marjorie Wood

Inventor： TianLing Chen ,  Diane Greeley ,  John David Rothermel ,  Markus Wartmann ,  Jeanette Marjorie Wood

IPC: A61K31/426 ,  A61K31/662 ,  A61K31/427 ,  A61K31/675 ,  A61P35/00

CPC classification number: A61K31/663 ,  A61K31/427 ,  A61K31/502 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.

Abstract translation: 本发明涉及一种组合，其包含（a）二膦酸盐，铂化合物或血管保护性化合物和（b）式I的埃坡霉素衍生物，其中A表示O或NRN，其中RN为氢或低级烷基，R为氢或 低级烷基和Z是O或键，其中活性成分（a）和（b）在每种情况下以游离形式或以药学上可接受的盐和任选的至少一种药学上可接受的载体的形式存在， 特别是延长进展或治疗增殖性疾病，特别是实体肿瘤疾病; 药物组合物，商业包装或包含这种组合的产品; 使用这种组合来制备用于延缓进展或治疗增殖性疾病的药物以及治疗温血动物的方法。

公开(公告)号：US20080119529A1

公开(公告)日：2008-05-22

申请号：US12019294

申请日：2008-01-24

Applicant: TianLing Chen ,  Diane Greeley ,  John Rothermel ,  Markus Wartmann ,  Jeanette Wood

Inventor： TianLing Chen ,  Diane Greeley ,  John Rothermel ,  Markus Wartmann ,  Jeanette Wood

IPC: A61K31/426 ,  A61P43/00 ,  C07D417/06

CPC classification number: A61K31/663 ,  A61K31/427 ,  A61K31/502 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.

Abstract translation: 本发明涉及一种组合，其包含（a）二膦酸盐，铂化合物或血管平滑化合物和（b）式I的埃坡霉素衍生物，其中A表示O或NR N，其中R

公开(公告)号：US07030147B2

公开(公告)日：2006-04-18

申请号：US10471904

申请日：2002-03-18

Applicant: John David Rothermel ,  Horst F. Schran ,  Diane Greeley ,  TianLing Chen

Inventor： John David Rothermel ,  Horst F. Schran ,  Diane Greeley ,  TianLing Chen

IPC: A61K43/78 ,  A61K31/425 ,  A61K43/00 ,  A61K31/33 ,  A61K43/02

CPC classification number: A61K45/06 ,  Y10S514/867 ,  Y10S514/974

Abstract: Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.

Abstract translation: 与治疗增殖性疾病的抗腹泻剂（例如DPP-IV抑制剂）共同施用埃博霉素衍生物。