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    METHODS AND SYSTEMS FOR REDUCING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT
    1.
    发明申请
    METHODS AND SYSTEMS FOR REDUCING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT 有权

    公开(公告)号：US20220211437A1

    公开(公告)日：2022-07-07

    申请号：US17703204

    申请日：2022-03-24

    申请人： DIGMA MEDICAL LTD.

    发明人： Ilan BEN-OREN ,  Avia HERSCHKOVITZ ,  Tamir WOLF ,  Irit YANIV

    IPC分类号： A61B18/24

    摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

    METHODS FOR SHORTENING A DUODENUM OF A SUBJECT
    3.
    发明公开
    METHODS FOR SHORTENING A DUODENUM OF A SUBJECT 审中-公开

    公开(公告)号：US20230301810A1

    公开(公告)日：2023-09-28

    申请号：US18124376

    申请日：2023-03-21

    申请人： Digma Medical Ltd.

    发明人： Shlomit CHAPPEL-RAM ,  Avia HERSCHKOVITZ

    IPC分类号： A61F5/00

    CPC分类号： A61F5/0076

    摘要： A method for shortening a duodenum of a subject, the method including: manipulating a first surface of the duodenum wall such that a first portion of the first surface of the duodenum wall is layered onto a second portion of the first surface of the duodenum wall, thereby creating at least one fold in the first surface of the duodenum wall, and securing, utilizing at least one implant, the position of the at least one fold in relation to a surrounding surface of the duodenum wall, thereby shortening the duodenum of the subject.

    APPARATUS AND METHOD FOR NERVE ABLATION IN THE WALL OF THE GASTOINTESTINAL TRACT
    4.
    发明申请
    APPARATUS AND METHOD FOR NERVE ABLATION IN THE WALL OF THE GASTOINTESTINAL TRACT 有权

    公开(公告)号：US20210361354A1

    公开(公告)日：2021-11-25

    申请号：US17393989

    申请日：2021-08-04

    申请人： DIGMA MEDICAL LTD.

    发明人： Ilan BEN OREN

    IPC分类号： A61B18/24 ,  A61B6/00 ,  A61B18/20 ,  A61B5/00 ,  A61B18/14

    摘要： Catheter for real-time evaluation of duodenal ablation, the catheter including an expandable member configured to stretch the duodenal wall and to generate a fixed distance between a center of the catheter and the duodenal wall; a laser transmitting element coupled with the catheter body and configured to transmit a first laser beam and a second laser beam; wherein the first laser beam is configured to cause ablative damage in a region of the duodenal wall as a result of its impingement thereon, and wherein the second laser beam is configured to detect modifications in the region of the duodenal wall resulting from the impingement of the first laser beam thereon.

    Methods and systems for reducing neural activity in an organ of a subject
    5.
    发明授权
    Methods and systems for reducing neural activity in an organ of a subject 有权

    公开(公告)号：US10925671B2

    公开(公告)日：2021-02-23

    申请号：US16136530

    申请日：2018-09-20

    申请人： DIGMA MEDICAL LTD.

    发明人： Ilan Ben-Oren ,  Avia Herschkovitz ,  Tamir Wolf ,  Irit Yaniv

    IPC分类号： A61B18/24 ,  A61N7/00 ,  A61B18/20 ,  A61B18/00 ,  A61B18/22

    摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

    METHODS AND SYSTEMS FOR BLOCKING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT, PREFERABLY IN THE SMALL INTESTINE OR THE DUODENUM
    6.
    发明申请
    METHODS AND SYSTEMS FOR BLOCKING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT, PREFERABLY IN THE SMALL INTESTINE OR THE DUODENUM 审中-公开
    用于阻塞一个主体的机器中的神经活动的方法和系统，优选地在小型内部或者DUODENUM

    公开(公告)号：US20170027645A1

    公开(公告)日：2017-02-02

    申请号：US15303080

    申请日：2015-04-16

    申请人： DIGMA MEDICAL LTD.

    发明人： Ilan BEN OREN ,  Irit YANIV ,  Tamir WOLF ,  Avia HERSCHKOVITZ

    IPC分类号： A61B18/22

    摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

    摘要翻译： 根据一些实施方案，本公开提供了用于选择性地减少，阻断或抑制受试者器官中的至少一部分神经活性的方法和系统。 在优选实施方案中，所述方法和系统用于选择性阻断需要其的受试者的十二指肠中的至少一部分神经活性。 根据一些实施例，通过使用激光辐射发生选择性阻塞。 根据一些实施例，通过使用超声能量发生选择性阻塞。 根据一些实施例，选择性阻塞包括对位于目标区域内的感觉神经的至少部分造成伤害，同时通过屏蔽激光辐射的作用来保持围绕感觉神经的组织的功能活动。 根据一些实施例，感觉神经包括被配置为传送由通过十二指肠的食物触发的信号的神经元，例如但不限于神经激素信号。

    Apparatus and method for selective submucosal ablation
    7.
    发明授权
    Apparatus and method for selective submucosal ablation 有权

    公开(公告)号：US11564743B1

    公开(公告)日：2023-01-31

    申请号：US16731253

    申请日：2019-12-31

    申请人： Digma Medical Ltd.

    发明人： Ilan Ben Oren ,  Boaz Behar

    IPC分类号： A61B18/14 ,  A61B18/24 ,  A61B18/00

    摘要： Device and method for selectively ablating a submucosal layer of a duodenal wall and/or of sensory neurons therein, including a laser transmitting element coupled with the catheter body and configured to transmit a laser beam having a spot diameter of less than 200 microns and to provide an ablative dose of 0.5-2.5 J/mm; wherein the laser beam is configured to selectively ablate an area of the submucosal layer that is at least twice the size of the spot diameter, while essentially preventing damage of the surrounding mucosal, muscularis and/or serosal layers of the duodenal wall; and an expandable member configured to stretch the duodenal wall and to generate a fixed distance between the catheter's laser transmitting element and the duodenal wall.

    Methods and systems for reducing neural activity in an organ of a subject
    9.
    发明授权
    Methods and systems for reducing neural activity in an organ of a subject 有权

    公开(公告)号：US10888377B2

    公开(公告)日：2021-01-12

    申请号：US15973053

    申请日：2018-05-07

    申请人： DIGMA MEDICAL LTD.

    发明人： Ilan Ben-Oren ,  Avia Herschkovitz ,  Tamir Wolf ,  Irit Yaniv

    IPC分类号： A61B18/24 ,  A61N7/00 ,  A61B18/20 ,  A61B18/00 ,  A61B18/22

    摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

    Methods and systems for blocking neural activity in an organ of a subject, preferably in the small intestine or the duodenum
    10.
    发明授权
    Methods and systems for blocking neural activity in an organ of a subject, preferably in the small intestine or the duodenum 有权

    公开(公告)号：US10537387B2

    公开(公告)日：2020-01-21

    申请号：US15303080

    申请日：2015-04-16

    申请人： DIGMA MEDICAL LTD.

    发明人： Ilan Ben Oren ,  Irit Yaniv ,  Tamir Wolf ,  Avia Herschkovitz

    IPC分类号： A61B18/20 ,  A61B18/00 ,  A61B5/00 ,  A61B18/22 ,  A61B8/08 ,  A61B8/12 ,  A61B1/012 ,  A61B5/026 ,  A61B5/055 ,  A61B5/107

    摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.