公开(公告)号：US20140322715A1

公开(公告)日：2014-10-30

申请号：US14237396

申请日：2011-08-12

申请人： Dirk Jan Kok ,  Jozef Stephanus Elisabeth Laven ,  Delshad Mama Maghdid ,  Nicole Geertje Maria Beckers

发明人： Dirk Jan Kok ,  Jozef Stephanus Elisabeth Laven ,  Delshad Mama Maghdid ,  Nicole Geertje Maria Beckers

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q1/6881 ,  C12Q2600/16 ,  G01N33/689 ,  G01N2333/31 ,  G01N2333/335

摘要： The invention comprises a method to determine the chance of a successful pregnancy based on the ratio of said ratio indicated as a formula that uses the presence of Lactobacillus and Staphylococcus bacteria in relation to the total amount of bacteria in a sample of a subject, preferably a urine sample. Also comprised in the invention is a kit, preferably a qPCR kit, for performing the method of the invention and outputting the result. Such a method and kit are particularly advantageous for predicting the chance of a successful pregnancy in subjects undergoing or eligible for an artificial insemination method such as IVF or ICSI.

摘要翻译： 本发明包括一种确定成功怀孕的机会的方法，所述方法基于所述比率指示为使用乳酸杆菌和葡萄球菌的存在的比例，相对于受试者样品中的细菌总量，优选为 尿样。 本发明还包括用于执行本发明方法并输出结果的试剂盒，优选qPCR试剂盒。 这样的方法和试剂盒特别有利于预测正在接受或符合IVF或ICSI的人工授精方法的受试者的成功怀孕的机会。

公开(公告)号：US09896733B2

公开(公告)日：2018-02-20

申请号：US14237396

申请日：2011-08-12

申请人： Dirk Jan Kok ,  Jozef Stephanus Elisabeth Laven ,  Delshad Mama Maghdid ,  Nicole Geertje Maria Beckers

发明人： Dirk Jan Kok ,  Jozef Stephanus Elisabeth Laven ,  Delshad Mama Maghdid ,  Nicole Geertje Maria Beckers

IPC分类号： C12Q1/68 ,  G01N33/68 ,  C07H21/02

CPC分类号： C12Q1/689 ,  C12Q1/6881 ,  C12Q2600/16 ,  G01N33/689 ,  G01N2333/31 ,  G01N2333/335

摘要： The disclosure provides a method of determining the chance of a successful pregnancy based on the ratio indicated as a formula that uses the presence of Lactobacillus and Staphylococcus bacteria in relation to the total amount of bacteria in a sample of a subject, preferably a urine sample. Also provided in the disclosure is a kit, preferably a qPCR kit, for performing the method of the disclosure and outputting the result. Such a method and kit are particularly advantageous for predicting the chance of a successful pregnancy in subjects undergoing or eligible for an artificial insemination method such as IVF or ICSI.