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公开(公告)号:US07148347B2
公开(公告)日:2006-12-12
申请号:US10818657
申请日:2004-04-06
申请人: Joerg Brandenburg , Kai Donsbach , Hans-Dieter Ecker , Rogelio Perez Frutos , Fabrice Gallou , Dieter Gutheil , Nizar Haddad , Robert Hagenkoetter , Dirk Kemmer , Jutta Kroeber , Thomas Nicola , Juergen Schnaubelt , Michael Schul , Robert Donald Simpson , Xudong Wei , Eric Winter , Yibo Xu , Nathan K. Yee
发明人: Joerg Brandenburg , Kai Donsbach , Hans-Dieter Ecker , Rogelio Perez Frutos , Fabrice Gallou , Dieter Gutheil , Nizar Haddad , Robert Hagenkoetter , Dirk Kemmer , Jutta Kroeber , Thomas Nicola , Juergen Schnaubelt , Michael Schul , Robert Donald Simpson , Xudong Wei , Eric Winter , Yibo Xu , Nathan K. Yee
IPC分类号: C07D207/09 , C07D245/04 , C07D267/02
CPC分类号: B01J31/2226 , B01J31/2265 , B01J31/2404 , B01J2231/543 , B01J2531/821 , C07D491/08 , C07K1/006 , C07K1/086 , C07K5/0804 , C07K5/0812
摘要: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
摘要翻译: 公开了一种制备式(I)的大环化合物的方法:其使用式(II)的中间体进行:其中W,R 1至R 4, SUP>,D,A和R 12如本文所定义。 式(I)化合物是用于治疗丙型肝炎病毒(HCV)感染的有效活性剂。
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公开(公告)号:US20120296091A1
公开(公告)日:2012-11-22
申请号:US13563767
申请日:2012-08-01
申请人: Peter SIEGER , Dirk KEMMER , Peter KOHLBAUER , Thomas NICOLA , Martin RENZ
发明人: Peter SIEGER , Dirk KEMMER , Peter KOHLBAUER , Thomas NICOLA , Martin RENZ
IPC分类号: C07D473/04
CPC分类号: C07D473/06 , C07B2200/13 , C07D473/04
摘要: The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
摘要翻译: 本发明涉及DPP-IV抑制剂的多晶型晶体改性剂,其制备方法及其用于制备药物的用途。
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公开(公告)号:US20070259900A1
公开(公告)日:2007-11-08
申请号:US11744700
申请日:2007-05-04
申请人: Peter SIEGER , Dirk Kemmer , Peter Kohlbauer , Thomas Nicola , Martin Renz
发明人: Peter SIEGER , Dirk Kemmer , Peter Kohlbauer , Thomas Nicola , Martin Renz
IPC分类号: A61K31/517 , C07D405/14
CPC分类号: C07D473/06 , C07B2200/13 , C07D473/04
摘要: The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
摘要翻译: 本发明涉及DPP-IV抑制剂的多晶型晶体改性剂,其制备方法及其用于制备药物的用途。
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公开(公告)号:US09266888B2
公开(公告)日:2016-02-23
申请号:US14462654
申请日:2014-08-19
申请人: Peter Sieger , Dirk Kemmer , Peter Kohlbauer , Thomas Nicola , Martin Renz
发明人: Peter Sieger , Dirk Kemmer , Peter Kohlbauer , Thomas Nicola , Martin Renz
IPC分类号: A61K31/505 , C07D473/04
CPC分类号: C07D473/06 , C07B2200/13 , C07D473/04
摘要: The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
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公开(公告)号:US20140357646A1
公开(公告)日:2014-12-04
申请号:US14462654
申请日:2014-08-19
申请人: Peter SIEGER , Dirk KEMMER , Peter KOHLBAUER , Thomas NICOLA , Martin RENZ
发明人: Peter SIEGER , Dirk KEMMER , Peter KOHLBAUER , Thomas NICOLA , Martin RENZ
IPC分类号: C07D473/04
CPC分类号: C07D473/06 , C07B2200/13 , C07D473/04
摘要: The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
摘要翻译: 本发明涉及DPP-IV抑制剂的多晶型晶体改性剂,其制备方法及其用于制备药物的用途。
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公开(公告)号:US20050049187A1
公开(公告)日:2005-03-03
申请号:US10818657
申请日:2004-04-06
申请人: Joerg Brandenburg , Kai Donsbach , Hans-Dieter Ecker , Rogelio Frutos , Fabrice Gallou , Dieter Gutheil , Nizar Haddad , Robert Hagenkoetter , Dirk Kemmer , Jutta Kroeber , Thomas Nicola , Juergen Schnaubelt , Michael Schul , Robert Simpson , Xudong Wei , Eric Winter , Yibo Xu , Nathan Yee
发明人: Joerg Brandenburg , Kai Donsbach , Hans-Dieter Ecker , Rogelio Frutos , Fabrice Gallou , Dieter Gutheil , Nizar Haddad , Robert Hagenkoetter , Dirk Kemmer , Jutta Kroeber , Thomas Nicola , Juergen Schnaubelt , Michael Schul , Robert Simpson , Xudong Wei , Eric Winter , Yibo Xu , Nathan Yee
IPC分类号: B01J31/22 , C07D491/08 , C07K1/00 , C07K1/08 , C07K5/083 , C07K5/087 , A61K38/12 , A61K31/4709 , C07K5/12
CPC分类号: B01J31/2226 , B01J31/2265 , B01J31/2404 , B01J2231/543 , B01J2531/821 , C07D491/08 , C07K1/006 , C07K1/086 , C07K5/0804 , C07K5/0812
摘要: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
摘要翻译: 公开了制备式(I)的大环化合物的方法:其使用式(II)的中间体进行:其中W,R 1至R 4,D,A和R 12 >如本文所定义。 式(I)化合物是用于治疗丙型肝炎病毒(HCV)感染的有效活性剂。
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