公开(公告)号：US06995838B2

公开(公告)日：2006-02-07

申请号：US10415421

申请日：2001-12-10

申请人： Dominique Blanchard ,  Stéphane Auger

发明人： Dominique Blanchard ,  Stéphane Auger

IPC分类号： G01N21/00 ,  G01N21/84

CPC分类号： G01N21/8901

摘要： The invention concerns a device for automatic surface inspection of an unwinding strip to detect surface defects, comprising at least a camera (10) whereof the optical axis is directed towards the surface to be inspected and forming on said surface a transverse line of sight (L) and at least an illuminating system (15) whereof the incident rays (Ri) are directed towards the transverse tranline of sight and distributed over the entire length of said line. At each point of the transverse line of sight, the observation direction of the camera (10) forms with the specular reflected ray at said point a constant angle.

摘要翻译： 本发明涉及一种用于自动表面检查展开条带以检测表面缺陷的装置，其包括至少一个相机（10），其中光轴指向待检查的表面，并在所述表面上形成横向视线（L ）和至少一个照明系统（15），其中入射光线（Ri）指向横向视线并分布在所述线的整个长度上。 在横向视线的每个点处，相机（10）的观察方向与所述点处的镜面反射光线形成恒定的角度。

公开(公告)号：US06440417B1

公开(公告)日：2002-08-27

申请号：US09434605

申请日：1999-11-05

申请人： Karen Thibaudeau ,  Dominique Blanchard ,  Dominique P. Bridon ,  Alan M. Ezrin ,  Margaret Hardy ,  Nissab Boudjellab

发明人： Karen Thibaudeau ,  Dominique Blanchard ,  Dominique P. Bridon ,  Alan M. Ezrin ,  Margaret Hardy ,  Nissab Boudjellab

IPC分类号： C07K1644

CPC分类号： C07K16/44 ,  A61K2039/505

摘要： Antibodies to a therapeutic agent and its derivatives and conjugates are disclosed, including antibodies to argatroban and its derivatives and conjugates. The antibodies are useful as reagents in assays and diagnostic kits for determining the concentration of a therapeutic agent or its derivatives and conjugates in biological samples, and further have therapeutic uses in treatment for potential toxicity associated with stable therapeutic conjugates and derivatives, both in vivo and ex vivo.

摘要翻译： 公开了治疗剂及其衍生物和缀合物的抗体，包括阿加曲班及其衍生物和缀合物的抗体。 该抗体可用作用于测定和诊断试剂盒中的试剂，用于确定生物样品中治疗剂或其衍生物和缀合物的浓度，并且还具有用于治疗与稳定的治疗性缀合物和衍生物相关的潜在毒性的治疗用途，包括体内和 离体

公开(公告)号：US6107489A

公开(公告)日：2000-08-22

申请号：US267274

申请日：1999-03-12

申请人： Alexander Krantz ,  Dominique Blanchard ,  Diane DeNagel ,  Yonghong Song

发明人： Alexander Krantz ,  Dominique Blanchard ,  Diane DeNagel ,  Yonghong Song

IPC分类号： C07D233/54 ,  A61K38/05

CPC分类号： C07D233/64

摘要： Novel compounds comprising chemically reactive intermediates which can react with available reactive functionalities on blood components to form covalent linkages, where the resulting covalently-bound conjugates are found to have renin inhibition activity are provided. Specifically, the renin inhibitor compounds of the present invention are tripeptide derivatives of a known renin inhibitor which can be covalently linked to chemically reactive functionalities on various blood components. The conjugated renin inhibitors thereby have extended lifetimes in the bloodstream, as compared to the unconjugated parent drug, and are, therefore, capable of maintaining renin inhibitory activity for extended periods of time as compared to the unconjugated parent drug. Also provided herein are methods for inhibiting renin activity in vivo comprising administering to the bloodstream of a mammalian host the novel compounds of the present invention.

摘要翻译： 提供了包含化学反应中间体的新型化合物，其可以与血液成分上的可用反应性官能团反应以形成共价键，其中发现所得的共价结合的缀合物具有肾素抑制活性。 具体地说，本发明的肾素抑制剂化合物是可以与各种血液成分上的化学反应性官能团共价连接的已知的肾素抑制剂的三肽衍生物。 与非共轭母体药物相比，缀合的肾素抑制剂在血液中的寿命延长，因此与未缀合的母体药物相比，能够延长延长的时间段内的肾素抑制活性。 本文还提供了用于在体内抑制肾素活性的方法，包括向哺乳动物宿主的血流施用本发明的新化合物。