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公开(公告)号：US5256801A
公开(公告)日：1993-10-26
申请号：US986852
申请日：1992-12-04
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： A process for the preparation of a compound of formula (I) ##STR1## comprising contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction solvent in the presence of a Lewis acid.
摘要翻译： 一种制备式（I）化合物的方法＆lt; IMAGE＆gt;包括在含有至少一种具有C-13位的酯键的紫杉烷化合物与至少一种硼氢化还原盐的反应溶剂中，在存在 的路易斯酸。
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公开(公告)号：US5281727A
公开(公告)日：1994-01-25
申请号：US982391
申请日：1992-11-27
申请人： David R. Carver , Timothy R. Prout , Christopher T. Workman , Donia L. Henderson , Charles L. Hughes
发明人： David R. Carver , Timothy R. Prout , Christopher T. Workman , Donia L. Henderson , Charles L. Hughes
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： The present invention is a method that uses an absorption column for the cleavage and recovery of taxanes, which are not normally detected as free taxanes. The method processes a first solution that contains standard detectable taxanes and other undetectable taxane compounds to generate a second solution that contains a higher percentage of detectable standard taxane then the first solution. The first step of this method is loading a column having a first opening and a second opening with an ion exchange media. The next step is placing the first solution in the first opening of the column so that the first solution passes through the ion exchange media in the column and flows to the second opening. Thus, the taxane compounds are converted to standard taxanes by an ion exchange reaction and the second solution is formed. Then the next step is collecting, from the second opening of the column, the second solution and recovering from the second solution a larger percentage of standard taxanes then was detectable in the first solution. The ion exchange media of the present solution is an ion exchange resin. The ion exchange resin can be a mixture of an anion exchange resin and a cation exchange resin. The anion exchange resin is in the OH-form. The cation exchange resin is in the H.sup.+ form. Preferably, the ion exchange resin is alumina.
摘要翻译： 本发明是使用吸收塔来分离和回收紫杉烷的方法，其通常不被视为游离紫杉烷。 该方法处理含有标准可检测的紫杉烷和其他不可检测的紫杉烷化合物的第一溶液以产生含有较高百分比的可检测标准紫杉烷的第二溶液，然后是第一溶液。 该方法的第一步是用离子交换介质装载具有第一开口和第二开口的柱。 下一步是将第一溶液置于塔的第一开口中，使得第一溶液通过塔中的离子交换介质并流到第二开口。 因此，紫杉烷化合物通过离子交换反应转化成标准紫杉烷并形成第二溶液。 然后，下一步是从第二个开口开始收集第二个溶液，然后从第二个溶液中回收，然后在第一个溶液中检测到较大百分比的标准紫杉烷。 本溶液的离子交换介质是离子交换树脂。 离子交换树脂可以是阴离子交换树脂和阳离子交换树脂的混合物。 阴离子交换树脂为OH型。 阳离子交换树脂为H +形式。 优选地，离子交换树脂是氧化铝。
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公开(公告)号：US5202448A
公开(公告)日：1993-04-13
申请号：US930840
申请日：1992-08-14
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： The present invention relates to a process of converting partially purified taxane mixtures into Baccatin III. The process for the preparation of Baccatin III includes contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction solvent in the present of a Lewis acid.
摘要翻译： 本发明涉及将部分纯化的紫杉烷混合物转化为浆果赤霉素III的方法。 制备浆果赤霉素III的方法包括在路易斯酸存在的反应溶剂中使包含至少一种在C-13位具有酯键的紫杉烷化合物与至少一种硼氢化物还原盐的混合物接触。
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