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公开(公告)号：US20080227805A1
公开(公告)日：2008-09-18
申请号：US12038890
申请日：2008-02-28
IPC分类号： A61K31/485
CPC分类号： A61K31/485 , A61K9/0019 , A61K47/44
摘要： An oil-in-water buprenorphine formulation including buprenorphine and a surfactant that emulsifies the buprenorphine in oil, wherein the drug release is controlled by varying the oil concentration and/or pH. A buprenorphine aqueous suspension formulation including a free base buprenorphine and a suspension stabilizer. A buprenorphine oil formulation including a buprenorphine salt suspended in a pharmaceutically acceptable oil. Methods of providing sustained release of buprenorphine over a period of time.
摘要翻译： 一种水包油丁丙诺啡制剂，其包括丁丙诺啡和在油中乳化丁丙诺非的表面活性剂，其中通过改变油浓度和/或pH来控制药物释放。 包含游离碱性丁丙诺啡和悬浮液稳定剂的丁丙诺啡水性悬浮液制剂。 包括悬浮在药学上可接受的油中的丁丙诺啡盐的丁丙诺啡油制剂。 在一段时间内提供丁丙诺啡持续释放的方法。
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公开(公告)号：US10463689B2
公开(公告)日：2019-11-05
申请号：US12904791
申请日：2010-10-14
摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
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公开(公告)号：US20110086069A1
公开(公告)日：2011-04-14
申请号：US12904791
申请日：2010-10-14
CPC分类号： A61K33/00 , A61K9/0053 , A61K9/2068 , A61K9/2866 , A61K9/5042
摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
摘要翻译： 本发明涉及亚硝酸盐如无机亚硝酸盐的药物组合物或其任何药学上可接受的盐，溶剂合物或前药，以及这些组合物的医疗用途。 可以配制用于口服给药的药物组合物可以提供亚硝酸根离子（NO2-）的即时释放或延长释放。 本发明的药物组合物可用于例如治疗慢性组织缺血。
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公开(公告)号：US20100093778A1
公开(公告)日：2010-04-15
申请号：US12636227
申请日：2009-12-11
IPC分类号： A61K31/485
CPC分类号： A61K31/485 , A61K9/0019 , A61K47/44
摘要： An oil-in-water buprenorphine formulation including buprenorphine and a surfactant that emulsifies the buprenorphine in oil, wherein the drug release is controlled by varying the oil concentration and/or pH. A buprenorphine aqueous suspension formulation including a free base buprenorphine and a suspension stabilizer. A buprenorphine oil formulation including a buprenorphine salt suspended in a pharmaceutically acceptable oil. Methods of providing sustained release of buprenorphine over a period of time.
摘要翻译： 一种水包油丁丙诺啡制剂，其包括丁丙诺啡和在油中乳化丁丙诺非的表面活性剂，其中通过改变油浓度和/或pH来控制药物释放。 包含游离碱性丁丙诺啡和悬浮液稳定剂的丁丙诺啡水性悬浮液制剂。 包括悬浮在药学上可接受的油中的丁丙诺啡盐的丁丙诺啡油制剂。 在一段时间内提供丁丙诺啡持续释放的方法。
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公开(公告)号：US06348209B2
公开(公告)日：2002-02-19
申请号：US09875680
申请日：2001-06-06
申请人： Michael E. Placke , Anthony R. Imondi , Michael J. Brooker , John E. Frye , Praful K. Shah , Douglas R. Flanagan, Jr. , Maureen D. Donovan
发明人： Michael E. Placke , Anthony R. Imondi , Michael J. Brooker , John E. Frye , Praful K. Shah , Douglas R. Flanagan, Jr. , Maureen D. Donovan
IPC分类号： A61F1300
CPC分类号： A61K9/0073 , A61K31/00
摘要： A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.
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公开(公告)号：US08455508B2
公开(公告)日：2013-06-04
申请号：US12636227
申请日：2009-12-11
CPC分类号： A61K31/485 , A61K9/0019 , A61K47/44
摘要： An oil-in-water buprenorphine formulation including buprenorphine and a surfactant that emulsifies the buprenorphine in oil, wherein the drug release is controlled by varying the oil concentration and/or pH. A buprenorphine aqueous suspension formulation including a free base buprenorphine and a suspension stabilizer. A buprenorphine oil formulation including a buprenorphine salt suspended in a pharmaceutically acceptable oil. Methods of providing sustained release of buprenorphine over a period of time.
摘要翻译： 一种水包油丁丙诺啡制剂，其包括丁丙诺啡和在油中乳化丁丙诺非的表面活性剂，其中通过改变油浓度和/或pH来控制药物释放。 包含游离碱性丁丙诺啡和悬浮液稳定剂的丁丙诺啡水性悬浮液制剂。 包括悬浮在药学上可接受的油中的丁丙诺啡盐的丁丙诺啡油制剂。 在一段时间内提供丁丙诺啡持续释放的方法。
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