公开(公告)号：US20090016995A1

公开(公告)日：2009-01-15

申请号：US11934940

申请日：2007-11-05

申请人： Douglas W. Ethell ,  Gary W. Arendash

发明人： Douglas W. Ethell ,  Gary W. Arendash

IPC分类号： A61K35/26 ,  A61P25/28

CPC分类号： C12N15/8509 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  A61K35/17 ,  A61K35/26 ,  A61K39/0007 ,  A61K2039/5158 ,  C07K14/4711

摘要： A method treating a subject with Alzheimer's disease wherein Aβ-reactive immune cells, splenocytes and lymphocytes, are generated in vitro or in vivo, re-stimulated in vitro, and then adoptively transferred into the cognitively-impaired subject. The population of immune cells can be derived from a donor with a natural or adaptive immune response to Aβ, stimulated by exposure to Aβ in vivo. The donor cells are then collected and re-stimulated by subsequent exposure to Aβ in vitro prior to administration to the subject. Alternatively, the population of immune cells can be derived from the subject and then stimulated by exposure to Aβ in vitro.

摘要翻译： 在体外或体内产生Abeta反应性免疫细胞，脾细胞和淋巴细胞的阿尔茨海默氏病治疗受试者的方法在体外重新刺激，然后过度转移到认知受损受试者中。 免疫细胞群可以从具有对Abeta的天然或适应性免疫应答的供体衍生，通过在体内暴露于Abeta刺激。 然后在施用给受试者之前收集供体细胞并随后再暴露于Abeta再刺激。 或者，免疫细胞群体可以从受试者中获得，然后通过体外暴露于Abeta来刺激。