公开(公告)号：US20240075114A1

公开(公告)日：2024-03-07

申请号：US18050314

申请日：2022-10-27

申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG

发明人： Stefan Barghorn ,  Simone Giaisi ,  Heinz Hillen ,  Andreas Striebinger

IPC分类号： A61K39/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  G01N33/68

CPC分类号： A61K39/0007 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4711 ,  C07K16/18 ,  G01N33/6896 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K2317/33 ,  C07K2317/34 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The invention relates to immunogenic products based on mutein amyloid β (Aβ) amino acid sequences, in particular to oligomers of Aβ muteins, and to the use of said products in diagnosis, treatment and prevention of conditions such as amyloidoses, and for identifying agents capable of binding to said products.

公开(公告)号：US20230340095A1

公开(公告)日：2023-10-26

申请号：US18314956

申请日：2023-05-10

申请人： TauC3 Biologics Limited

发明人： Daniel G. Chain

IPC分类号： C07K16/18 ,  C07K14/47 ,  A61P25/00 ,  A61P37/04 ,  A61P25/28

CPC分类号： C07K16/18 ,  C07K14/4711 ,  A61P25/00 ,  A61P37/04 ,  A61P25/28 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/76

摘要： The invention is directed to methods of treatment of Alzheimer's disease and other tauopathies, via the administration of antibodies having specificity to abnormal forms of tau protein, the antibodies showing no binding and/or reactivity to a normal tau protein and being administered under conditions and in amounts effective to prevent or treat Alzheimer's disease or other tauopathies. In certain embodiments, the antibodies are selective for soluble truncated tau protein truncated at (i) its C-terminus after the glutamic acid residue Glu391, or (ii) at the aspartic acid residue Asp421, or (iii) at its N-terminus at the aspartic acid residue Asp13, or (iv) a combination of (i)-(iii). Further aspects of the invention are directed to the administration of an immunogen comprising an abnormal tau, preferably a soluble truncated tau.

公开(公告)号：US20230312662A1

公开(公告)日：2023-10-05

申请号：US18328557

申请日：2023-06-02

申请人： OTHAIR PROTHENA LIMITED

发明人： Robin Barbour ,  Gene Kinney ,  Wagner Zago ,  Tarlochan S. Nijjar

IPC分类号： C07K14/47 ,  A61P25/28 ,  A61P37/04 ,  A61K39/00 ,  A61K39/39

CPC分类号： C07K14/4711 ,  A61P25/28 ,  A61P37/04 ,  A61K39/0007 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/575 ,  A61K2039/6037 ,  C07K2319/00

摘要： The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or tau, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide.

公开(公告)号：US20230295283A1

公开(公告)日：2023-09-21

申请号：US18066998

申请日：2022-12-15

申请人： BioArctic Neruoscience AB

发明人： Par Gellerfors ,  Lars Lannfelt ,  Linda Soderberg ,  Karin Tegerstedt

IPC分类号： C07K16/18 ,  C07K14/47

CPC分类号： C07K16/18 ,  C07K14/4711 ,  A61K38/00

摘要： A vaccine for delaying onset of or for treatment of Alzheimer's disease or an Alzheimer-related disorder in an individual comprises a therapeutically effective amount of a physiologically acceptable protofibril/oligomer comprising N-terminal truncated Aβ. An antibody for delaying an onset of or for treatment of Alzheimer's disease or an Alzheimer-related disorder in an individual hinds one or more truncated Aβ protofibrils/oligomers, but exhibits no or substantially no cross-reactivity with full length Aβ monomers, and optionally said antibody shows cross-reactivity to N-terminal truncated Aβ monomers. Methods for delaying an onset of or for treatment of Alzheimer's disease or an Alzheimer-related disorder employ the vaccine or antibody. Methods of detecting soluble N-terminal truncated amyloid-beta (Aβ) protofibrils/oligomers and N-terminal truncated Aβ monomers employ the antibody.

公开(公告)号：US20230279088A1

公开(公告)日：2023-09-07

申请号：US18183812

申请日：2023-03-14

申请人： National Research Council of Canada

发明人： Balu Chakravarthy ,  Danica Stanimirovic ,  Yves Durocher

IPC分类号： C07K16/18 ,  C07K14/47 ,  A61K9/00

CPC分类号： C07K16/18 ,  C07K14/4711 ,  A61K9/0019 ,  C07K2317/569 ,  C07K2317/24 ,  C07K2319/70 ,  C07K2319/33 ,  C07K2317/565 ,  C07K2319/10 ,  C07K2319/30

摘要： A brain-penetrating composition of amyloid-β binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-β targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.

公开(公告)号：US11702466B2

公开(公告)日：2023-07-18

申请号：US16481898

申请日：2018-01-30

申请人： National Research Council of Canada

发明人： Balu Chakravarthy ,  Danica Stanimirovic ,  Yves Durocher

IPC分类号： C07K16/46 ,  C07K16/00 ,  C07K14/00 ,  A61K39/00 ,  A61K38/00 ,  C07K16/18 ,  A61K9/00 ,  C07K14/47

CPC分类号： C07K16/18 ,  A61K9/0019 ,  C07K14/4711 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2319/10 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/70

摘要： A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.

公开(公告)号：US11701436B2

公开(公告)日：2023-07-18

申请号：US17494457

申请日：2021-10-05

申请人： Wisconsin Alumni Research Foundation

发明人： Subhojit Roy ,  Jichao Sun

IPC分类号： A61P25/28 ,  A61K48/00 ,  A61K9/00 ,  C12N15/90 ,  C07K14/47 ,  C12N9/22 ,  C12N15/10

CPC分类号： A61K48/0066 ,  A61K9/0019 ,  A61K48/0008 ,  A61K48/0058 ,  A61K48/0075 ,  A61P25/28 ,  C07K14/4711 ,  C12N9/22 ,  C12N15/102 ,  C12N15/907 ,  C12N2310/20 ,  C12N2740/16043 ,  C12N2750/14143

摘要： Described herein is a method for treating Alzheimer's disease (AD) by selective silencing of the amyloid precursor protein (APP) using Cas9 nuclease gene editing. Methods of making and using genetic constructs comprising a Cas9 nuclease and a sequence encoding guide RNA (gRNA) specific to APP capable of truncating the C-terminus of APP, as well as compositions comprising these constructs, are provided.

公开(公告)号：US20190194280A1

公开(公告)日：2019-06-27

申请号：US16237531

申请日：2018-12-31

申请人： United Biomedical, Inc.

发明人： Chang Yi Wang

IPC分类号： C07K14/47 ,  C12N7/00 ,  C07K16/18 ,  C07K14/34 ,  A61K39/39 ,  A61K9/00 ,  A61K39/00

CPC分类号： C07K14/4711 ,  A61K9/0019 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/58 ,  C07K14/34 ,  C07K16/18 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2760/18434

摘要： The present disclosure is directed to individual Aβ peptide immunogen constructs, peptide compositions comprising these Aβ peptide immunogen constructs and mixtures thereof, pharmaceutical compositions including vaccine formulations comprising these Aβ peptide immunogen constructs, with the individual Aβ peptide immunogen constructs having the N-terminus of the Aβ peptide as the B cell (B) epitopes linked through spacer residue(s) to heterologous T helper cell (Th) epitopes derived from pathogen proteins that act together to stimulate the generation of highly specific antibodies directed against the N-terminus of the Aβ peptide offering protective immune responses to patients at risk for, or with, Alzheimer's Disease.

公开(公告)号：US20180326027A1

公开(公告)日：2018-11-15

申请号：US15774736

申请日：2016-11-09

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Neil R. CASHMAN ,  Steven S. PLOTKIN

IPC分类号： A61K39/00 ,  A61K45/00 ,  A61K47/64 ,  A61P25/28 ,  A61P37/06 ,  C07K14/47 ,  C07K16/18 ,  C07K5/103 ,  C07K5/107 ,  C07K5/113 ,  C07K7/06 ,  C07K7/64

CPC分类号： A61K39/0008 ,  A61K39/0007 ,  A61K45/05 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6081 ,  A61K2300/00 ,  A61P25/28 ,  A61P37/06 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/64 ,  C07K14/47 ,  C07K14/4711 ,  C07K16/18 ,  C07K2317/76 ,  G01N2333/4709

摘要： The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

公开(公告)号：US20180312558A1

公开(公告)日：2018-11-01

申请号：US16018447

申请日：2018-06-26

申请人： JAPAN SCIENCE AND TECHNOLOGY AGENCY

发明人： Motomu Kanai ,  Yohei Soma ,  Atsuhiko Taniguchi ,  Daisuke Sasaki

IPC分类号： C07K14/47 ,  C07K1/113 ,  A61K38/00

CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K1/113

摘要： The invention provides an Aβ peptide aggregation inhibitor, an Aβ peptide toxicity reducing agent, and a preventive and/or therapeutic agent for Alzheimer's disease. The oxidized Aβ peptide in which one or more amino acid residues of Aβ peptide have been oxidized (excluding an oxidized Aβ peptide in which only Met has been oxidized).