公开(公告)号：US20230151439A1

公开(公告)日：2023-05-18

申请号：US17606554

申请日：2020-05-07

申请人： INSTITUT PASTEUR ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  INSERM (Institut National de la Sante et de la Recherche Medicale) ,  SORBONNE UNIVERSITE ,  INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE - ICM ,  ECOLE NATIONALE VETERINAIRE DE MAISONS ALFORT ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

发明人： Marc ELOIT ,  Philippe PEROT ,  Danielle SEILHEAN ,  Charles DUYCKAERTS ,  Delphine CHRETIEN

IPC分类号： C12Q1/70

CPC分类号： C12Q1/701 ,  C12Q1/6841

摘要： The invention relates to methods of diagnosis or detection of Moissiacense virus, a novel orthobunyavirus causing human encephalitis, comprising determining the presence of at least one nucleic acid or protein of said virus or antibodies thereto, in a biological sample. The invention also relates to the various diagnostic agents derived from the viral nucleic acids or proteins, in articular nucleic acid primers and probes, antigens and antibodies, and their use for the diagnosis of Moissiacense virus infection and associated disease, in particular encephalitis. The invention further relates to antigens derived from the viral proteins as vaccine for the prevention of Moissiacense virus infection and associated disease, in particular encephalitis.