公开(公告)号：US20210198755A1

公开(公告)日：2021-07-01

申请号：US17124478

申请日：2020-12-16

Applicant: INSTITUT PASTEUR ,  INSTITUT PASTEUR DU CAMBODGE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Frederic ARIEY ,  Odile PUIJALON ,  Didier MENARD ,  Francoise BENOIT-VICAL ,  Johann BEGHAIN ,  Benoit WITKOWSKI ,  Jean-Christophe BARALE ,  Christiane BOUCHIER ,  Nimol KHIM

IPC: C12Q1/6893

Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.

公开(公告)号：US12168805B2

公开(公告)日：2024-12-17

申请号：US16324140

申请日：2017-08-04

Applicant: INSTITUT PASTEUR ,  INSTITUT PASTEUR DU CAMBODGE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Didier Menard ,  Frédéric Ariey ,  Benoit Witkowski ,  Valentine Duru ,  Nimol Khim ,  Johann Beghain ,  Benjamin Saint Pierre ,  Eric Legrand

IPC: C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6893

Abstract: A method for genotyping a Plasmodium comprising: (a) providing a sample containing a Plasmodium; and (b) detecting the presence of an increased copy number of the genomic plasmepsin2-3 cluster. A method for the detection of a Plasmodium infection in a patient comprising: (a) providing a blood sample from a patient and (b) detecting the presence or absence of an increased copy number of the genomic plasmepsin2-3 cluster in the blood sample. Kits for genotyping a Plasmodium and/or detection of a Plasmodium infection. Methods of treating a Plasmodium infection.

公开(公告)号：US11732312B2

公开(公告)日：2023-08-22

申请号：US17124478

申请日：2020-12-16

Applicant: INSTITUT PASTEUR ,  INSTITUT PASTEUR DU CAMBODGE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Frederic Ariey ,  Odile Puijalon ,  Didier Menard ,  Francoise Benoit-Vical ,  Johann Beghain ,  Benoit Witkowski ,  Jean-Christophe Barale ,  Christiane Bouchier ,  Nimol Khim

IPC: C12Q1/6893

CPC classification number: C12Q1/6893 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/445 ,  Y02A50/30

Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.

公开(公告)号：US10900093B2

公开(公告)日：2021-01-26

申请号：US15036064

申请日：2014-11-14

Applicant: INSTITUT PASTEUR ,  INSTITUT PASTEUR DU CAMBODGE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Frederic Ariey ,  Odile Puijalon ,  Didier Menard ,  Francoise Benoit-Vical ,  Johann Beghain ,  Benoit Witkowski ,  Jean-Christophe Barale ,  Christiane Bouchier ,  Nimol Khim

IPC: C12Q1/6893 ,  C12Q1/68

Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.

公开(公告)号：US20220341933A1

公开(公告)日：2022-10-27

申请号：US17761767

申请日：2020-09-25

Applicant: INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  Institut Pasteur du Cambodge

Inventor： Marie FLAMAND ,  Kyu-Ho Paul PARK ,  Souheyla BENFRID ,  Carole TAMIETTI ,  James VOSS ,  Fasseli COULIBALY ,  Veasna DUONG ,  Philippe DUSSART ,  Anavaj SAKUNTABHAI ,  Quentin GIAI GIANETTO ,  Mariette MATONDO ,  Mariano DELLAROLE ,  Francois BONTEMS ,  Felix REY

IPC: G01N33/569 ,  G01N33/92 ,  G01N33/543

Abstract: The invention concerns methods for early detection, monitoring and prognosis of a flavivirus-induced infection, comprising the detection of a complex formed by the flavivirus non-structural glycoprotein NS1 and plasma lipoprotein particles in a biological anti-NS1 Mab sample during the clinical phase of the infection.

公开(公告)号：US11034730B2

公开(公告)日：2021-06-15

申请号：US16360970

申请日：2019-03-21

Applicant: INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT PASTEUR DU CAMBODGE

Inventor： Frederic Tangy ,  Anavaj Sakuntabhai ,  Etienne Simon-Loriere ,  Claude Roth ,  Philippe Buchy

IPC: C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  C07K14/18 ,  A61K39/00

Abstract: The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in particular polynucleotides, vectors, cells and methods to produce vectors expressing said chimeric polyepitopes, in particular vectors consisting of recombinant measles virus (MV) particles. The present invention also relates to the use of the recombinant MV particles, in particular under the form of a composition or of a vaccine, for the prevention and/or treatment of a dengue virus infection.

公开(公告)号：US20190218623A1

公开(公告)日：2019-07-18

申请号：US16324140

申请日：2017-08-04

Applicant: INSTITUT PASTEUR ,  INSTITUT PASTEUR DU CAMBODGE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： DIDIER MENARD ,  FRÉDÉRIC ARIEY ,  BENOIT WITKOWSKI ,  VALENTINE DURU ,  NIMOL KHIM ,  JOHANN BEGHAIN ,  BENJAMIN SAINT PIERRE ,  ERIC LEGRAND

IPC: C12Q1/6893 ,  C12Q1/6827

CPC classification number: C12Q1/6893 ,  C12Q1/6827 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/445 ,  Y02A50/58 ,  C12Q2537/16

Abstract: A method for genotyping a Plasmodium comprising: (a) providing a sample containing a Plasmodium; and (b) detecting the presence of an increased copy number of the genomic plasmepsin2-3 cluster. A method for the detection of a Plasmodium infection in a patient comprising: (a) providing a blood sample from a patient and (b) detecting the presence or absence of an increased copy number of the genomic plasmepsin2-3 cluster in the blood sample. Kits for genotyping a Plasmodium and/or detection of a Plasmodium infection. Methods of treating a Plasmodium infection.

公开(公告)号：US20180137236A1

公开(公告)日：2018-05-17

申请号：US15814788

申请日：2017-11-16

Applicant: Institut Pasteur de Montevideo ,  Instituto Carlos Chagas, Fiocruz - Paraná ,  Institut Pasteur

Inventor： Paulo C. Carvalho ,  Carlos Batthyány ,  André R. F. Silva ,  Diogo Borges Lima ,  Valmir Carneiro Barbosa ,  Alejandro Leyva ,  Rosario Duran ,  Julia Chamot-Rooke

IPC: G06F19/18 ,  G06F19/20 ,  G01N33/68

CPC classification number: G16B20/00 ,  G01N33/6803 ,  G16B25/00 ,  G16C20/20 ,  G16C20/70

Abstract: A system, method, computer readable medium and device for identifying discriminant spectrum clusters including receiving known input data set comprising spectra generated from biological samples known to either have or not have a biological condition where each spectrum may be either known to have been generated from the biological samples known to have or a biological condition, or from the biological samples known not to have same. A software module may apply quality control filters to the input data set to exclude spectra that do not meet the quality control filters, generate a set of remaining spectra, cluster same into a set of spectrum clusters by applying clustering parameters, and identify a set of discriminant spectrum clusters by examining whether each spectrum cluster exclusively contains only spectra generated from samples known to have a biological condition or exclusively contains spectra from samples known not to have the biological condition.

公开(公告)号：US20160289774A1

公开(公告)日：2016-10-06

申请号：US15036064

申请日：2014-11-14

Applicant: INSTITUT PASTEUR ,  INSTITUT PASTEUR DU CAMBODGE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Frederic ARIEY ,  Odile PUIJALON ,  Didier MENARD ,  Francoise BENOIT-VICAL ,  Johann BEGHAIN ,  Benoit WITKOWSKI ,  Jean-Christophe BARALE ,  Christiane BOUCHIER ,  Nimol KHIM

IPC: C12Q1/68

CPC classification number: C12Q1/6893 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/445 ,  Y02A50/58

Abstract: K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.

Abstract translation: K13螺旋桨多态性是追踪耐药性恶性疟原虫的出现和传播的有用的分子标记。 本发明包括用于检测和基因分型疟原虫的方法，组合物和试剂盒，例如恶性疟原虫。 方法，组合物和试剂盒可用于检测样品中突变的K-13螺旋桨核酸或蛋白质的存在或不存在。

公开(公告)号：US20250041564A1

公开(公告)日：2025-02-06

申请号：US18713519

申请日：2022-11-28

Applicant: UNIVERSITE DE BORDEAUX ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE – INSERM ,  CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX ,  INSTITUT PASTEUR

Inventor： Damien BONNARD ,  Raphaël DEVILLARD ,  Didier DULON ,  Olivia KEROUREDAN

IPC: A61M25/00

Abstract: A medical device for the delivery of a therapeutic agent by bioprinting including a rod body including a bioprinting cartridge arranged near the distal end of the rod body including a top layer including a solution containing a therapeutic agent; and an absorbent compound capable of converting light energy from laser radiation into thermal energy and arranged to cause heating of the solution including a therapeutic agent to cause a jet of the solution; an optical fiber extending longitudinally within a lumen of the rod body to deliver laser flow onto the absorbing compound.