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    C-4″-substituted macrolide derivatives
    1.
    发明授权
    C-4″-substituted macrolide derivatives 失效
    C-4“取代的大环内酯衍生物

    公开(公告)号：US06576749B2

    公开(公告)日：2003-06-10

    申请号：US10084279

    申请日：2002-02-26

    申请人： Brian Scott Bronk ,  Takushi Kaneko ,  Michael Anthony Letavic ,  Hengmaio Cheng ,  Edward Alan Glazer ,  Bingwei Vera Yang

    发明人： Brian Scott Bronk ,  Takushi Kaneko ,  Michael Anthony Letavic ,  Hengmaio Cheng ,  Edward Alan Glazer ,  Bingwei Vera Yang

    IPC分类号： C07H100

    CPC分类号： C07H17/08

    摘要： Compounds are of the formula: and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial agents that can be used to treat various bacterial infections and disorders related to such infections. The invention also relates to pharmaceutical compositions including the compounds of formula 1 and to methods of treating bacterial infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.

    摘要翻译： 化合物具有下式：及其药学上可接受的盐。 式1的化合物是可用于治疗各种细菌感染和与这种感染有关的疾病的有效的抗菌剂。 本发明还涉及包含式1化合物的药物组合物和通过施用式1化合物治疗细菌感染的方法。本发明还涉及制备式1化合物的方法和用于此类制备的中间体。

    C-4″-substituted macrolide derivatives
    4.
    发明授权
    C-4″-substituted macrolide derivatives 失效
    C-4“取代的大环内酯衍生物

    公开(公告)号：US06407074B1

    公开(公告)日：2002-06-18

    申请号：US09424211

    申请日：2000-02-16

    申请人： Brian Scott Bronk ,  Takushi Kaneko ,  Michael Anthony Letavic ,  Hengmaio Cheng ,  Edward Alan Glazer ,  Bingwei Vera Yang

    发明人： Brian Scott Bronk ,  Takushi Kaneko ,  Michael Anthony Letavic ,  Hengmaio Cheng ,  Edward Alan Glazer ,  Bingwei Vera Yang

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： This invention relates to compounds of the formula and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial agents that may be used to treat various bacterial infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.

    摘要翻译： 本发明涉及式的化合物及其药学上可接受的盐。 式1的化合物是可用于治疗各种细菌感染和与这种感染有关的疾病的有效的抗菌剂。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物治疗细菌感染的方法。本发明还涉及制备式1化合物的方法和用于此类制备的中间体。