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公开(公告)号：US20240262856A1
公开(公告)日：2024-08-08
申请号：US18563056
申请日：2022-06-08
Applicant: Acies Bio d.o.o.
Inventor： Nika Lendero Krajnc , Gregor Kosec , Petra Kralj , Stefan Fujs , Mirjan Svagelj , Nicholas Camp
Abstract: The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
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公开(公告)号：US20230250124A1
公开(公告)日：2023-08-10
申请号：US17773279
申请日：2020-10-27
Applicant: HIKAL LIMITED , GALAPAGOS
Inventor： Sudhir NAMBIAR , Rakesh Ramesh GANORKAR , Kiran CHAUDHARI , Anil GOHAR , Deeksha SINGH , Patrick CLAERHOUT STIJN POL
Abstract: The present invention relates to substantially pure Clarithromycin 9-oxime more particularly Clarithromycin 9(E)-oxime having purity more than 98% and corresponding (Z)-isomer not more than 1%. The present invention further relates to a process for preparation of Clarithromycin 9(E)-oxime of formula (I), its pharmaceutically acceptable salts and purification.
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公开(公告)号：US11673910B2
公开(公告)日：2023-06-13
申请号：US16609120
申请日：2018-04-27
Inventor： Andrew G. Myers , Ziyang Zhang , Takehiro Fukuzaki , Udara Anulal Premachandra Ilandari Dewage , Senkara Rao Allu , Roger B. Clark , Jonathan F. Lawrence , Wesley Francis Austin , Xiben Li , Wenying Wang , Sushmita D. Lahiri , Yoshitaka Ichikawa
Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6′-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
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公开(公告)号：US20230159581A1
公开(公告)日：2023-05-25
申请号：US17873451
申请日：2022-07-26
Applicant: Michael W. Burnet , Synovo GmbH
Inventor： Nikolas Pietrzik , Michael W. Burnet , Christiane Baeuerlein , Mary Eggers , Jan-Hinrich Guse , Ulrike Hahn , Simon Strass
IPC: C07H17/08 , C07C217/40 , C07D215/42 , C07D401/04
CPC classification number: C07H17/08 , C07C217/40 , C07D215/42 , C07D401/04 , A61K45/06
Abstract: Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer and anti-bacterial activity. They are useful in treating infectious, inflammatory and malignant disease.
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公开(公告)号：US20180250319A1
公开(公告)日：2018-09-06
申请号：US15782655
申请日：2017-10-12
Applicant: ACEA Biotech, Inc.
Inventor： Josefino B. Tunac
IPC: A61K31/704 , A61K9/20 , A61K9/08 , A61K9/00 , C07H17/08 , C07D493/08 , A61K31/7048
CPC classification number: A61K31/704 , A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/08 , A61K9/2045 , A61K9/205 , A61K31/7048 , C07D493/08 , C07H17/08 , Y02A50/409
Abstract: In certain aspects, the present disclosure provides for novel, water-soluble polyene macrolides and salts or solvates thereof and methods of making the water-soluble polyene macrolides. Also provided are compositions and methods for inhibiting, preventing, and/or treating fungal and parasitic diseases in a subject.
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Patent Agency Ranking
公开(公告)号：US20180243269A1
公开(公告)日：2018-08-30
申请号：US15968456
申请日：2018-05-01
Applicant: Wisconsin Alumni Research Foundation
Inventor： Timothy BUGNI , Thomas WYCHE , David ANDES , Douglas BRAUN
IPC: A61K31/429 , A61K45/06 , C07D513/18 , A61K31/7048 , C07H17/08 , A61K31/7052
CPC classification number: A61K31/429 , A61K31/7048 , A61K31/7052 , A61K45/06 , C07D513/18 , C07H17/08 , A61K2300/00
Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
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公开(公告)号：US20180230067A1
公开(公告)日：2018-08-16
申请号：US15751368
申请日：2016-09-28
Applicant: FUJIFILM FINECHEMICALS CO., LTD.,
Inventor： Akira KEMMOKU , Yayoi HAGA , Fumio KAWAMOTO
IPC: C07B41/06 , C07H17/08 , C07D211/22 , B01J19/00
CPC classification number: C07B41/06 , B01J19/0093 , B01J2219/0086 , C07C247/10 , C07D211/22 , C07H17/08 , Y02P20/55
Abstract: A method of producing an aldehyde compound or a ketone compound by oxidation of a primary or secondary alcohol compound having, in the molecule, a group selected from an amino group, an azido group, a hydroxy group, and a hydroxy group protected with a protective group, the method containing the steps of: a first step including colliding and mixing the alcohol compound, a dialkyl sulfoxide having 2 to 8 carbon atoms, and an acid anhydride having 4 to 10 carbon atoms in a flow-through type reactor to cause a reaction; and a second step including colliding and mixing, in a flow-through type reactor, a trialkylamine having 3 to 10 carbon atoms and the mixture liquid obtained in the first step to cause a reaction; wherein the reactions in the first step and the second step are sequentially performed.
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公开(公告)号：US20180179244A1
公开(公告)日：2018-06-28
申请号：US15324555
申请日：2015-07-07
Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
Inventor： Huijun REN , Daochao LI , Xuexiao YING , Feng CHEN , Linghui ZHENG , Lingping WANG , Hua BAI
Abstract: A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.
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公开(公告)号：US09970041B2
公开(公告)日：2018-05-15
申请号：US14419955
申请日：2013-07-30
Applicant: OLON SPA
Inventor： Guido Trione , Antonella Malcangi
Abstract: The present invention relates to a procedure for the production of tiacumicin B comprising fermentation of a micro-organism capable of producing tiacumicin B, in particular of the species Dactylosporangium aurantiacum or Actinoplanes deccanensis, in a culture broth containing emulsifiers, such as ethoxylated castor oil, in combination with antifoaming products and vegetable oils.
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公开(公告)号：US20180066008A1
公开(公告)日：2018-03-08
申请号：US15558896
申请日：2016-03-25
Applicant: President and Fellows of Harvard College
Inventor： Andrew G. MYERS , Ian Bass ESIPLE , Ziyang ZHANG
Abstract: Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered ketolides and 14-, 15-, and 16-membered azaketolides described herein comprise modified sugars which are desosamine or mycaminose analogs. Pharmaceutical compositions and methods of treating infection diseases and inflammatory conditions using the inventive macrolides are also provided. This disclosure additionally provides methods of preparing the macrolides by the coupling of an eastern and western half.
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