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    LC-MS SEPARATION AND DETECTION OF VITAMIN D METABOLITES
    4.
    发明申请
    LC-MS SEPARATION AND DETECTION OF VITAMIN D METABOLITES 审中-公开
    维生素D代谢物的LC-MS分离和检测

    公开(公告)号：US20140147878A1

    公开(公告)日：2014-05-29

    申请号：US13881843

    申请日：2011-10-28

    申请人： Joseph L. Herman ,  Dayana Argoti

    发明人： Joseph L. Herman ,  Dayana Argoti

    IPC分类号： G01N33/82

    CPC分类号： G01N33/82 ,  G01N2560/00 ,  Y10T436/203332

    摘要： Systems, kits, and methods for quantitation of metabolites of vitamin D by liquid chromatography-mass spectrometry (LC-MS). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([M+H]+) for the vitamin D metabolites in the ionization source (e.g., electrospray ionization (“ESI”)). Formation of the molecular ion does not involve loss of a water molecule from the parent molecule. Subsequent fragmentation of the [M+H]+ ion yields product ions that are specific to each molecular ion. The systems, kits, and methods described herein provide for no compromise in specificity and provide for a significant increase in sensitivity relative to previously described methods.

    摘要翻译： 通过液相色谱 - 质谱（LC-MS）定量维生素D代谢物的系统，试剂盒和方法。 本文所述的系统，试剂盒和方法稳定和/或促进电离源（例如，电喷雾离子化（“ESI”））中维生素D代谢物的质子化分子离子（[M + H] +）的形成）。 分子离子的形成不涉及从母体分子损失水分子。 随后的[M + H] +离子的断裂产生对每个分子离子特异的产物离子。 本文所述的系统，试剂盒和方法提供了特异性的妥协，并且提供了相对于先前描述的方法显着增加的灵敏度。

    Aqueous indolocarbazole solutions
    6.
    发明授权
    Aqueous indolocarbazole solutions 失效
    水性吲哚咯唑溶液

    公开(公告)号：US5599808A

    公开(公告)日：1997-02-04

    申请号：US383414

    申请日：1995-02-03

    申请人： Joel D. Goldstein ,  Joseph L. Herman

    发明人： Joel D. Goldstein ,  Joseph L. Herman

    IPC分类号： A61K9/00 ,  A61K31/40 ,  A61K31/55 ,  A61K31/70 ,  A61K47/10 ,  A61K47/32 ,  A61K47/00 ,  A61K47/12

    CPC分类号： A61K9/0019 ,  A61K31/40 ,  A61K31/55 ,  A61K31/70 ,  A61K47/10 ,  A61K47/32

    摘要： Disclosed herein are aqueous indolocarbazole solutions. In one embodiment, the invention features a solution comprising: (1) an indolocarbazole; (ii) a selected organic solvent being present in a concentration of between about 1% and about 99% by weight inclusive, (iii) a dispersant being present in a concentration of between about 0.25% and about 10% by weight inclusive; (iv) water being present in a concentration of between 0% and about 99% by weight inclusive, and (v) a polyethylene glycol being present in a concentration of between 0% and about 60% by weight inclusive.

    摘要翻译： 本文公开了含水吲哚并咔唑溶液。 在一个实施方案中，本发明的特征在于一种溶液，其包含：（1）吲哚并咔唑; （ii）所选择的有机溶剂以约1％至约99％重量的浓度存在，（iii）分散剂以约0.25％至约10％重量的浓度存在; （iv）以0％至约99％（重量）以下的浓度存在水，和（v）聚乙二醇以0％至约60％（重量）以下的浓度存在。

    Galvanizing apparatus for wire and the like
    7.
    发明授权
    Galvanizing apparatus for wire and the like 失效
    电线用镀锌装置等

    公开(公告)号：US4191127A

    公开(公告)日：1980-03-04

    申请号：US848712

    申请日：1977-11-04

    申请人： Joseph L. Herman

    发明人： Joseph L. Herman

    IPC分类号： C23C2/22 ,  C23C2/38 ,  B05C5/00 ,  B05C11/04 ,  B05C11/06 ,  B05C11/08

    CPC分类号： C23C2/38 ,  C23C2/22

    摘要： A method and apparatus for galvanizing galvanizable metal in a wire-like form. A descaled wire or the like is passed vertically and upwardly through a transversely flowing stream of molten zinc after which the so-coated wire or the like is either passed into a second processing zone or is passed through a shaping orifice, or both, as desired. The resulting so-processed wire is then cooled preferably by quenching in a flowing water bath.

    摘要翻译： 一种以线状形式镀锌可镀金属的方法和装置。 通过横向流动的熔融锌流，使除锈丝等垂直向上穿过，之后将如此涂覆的线或类似物进入第二处理区或者根据需要通过成形孔或两者 。 然后将所得到的经处理的线优选通过在流动水浴中淬火来冷却。

    LC-MS separation and detection of vitamin D metabolites
    8.
    发明授权
    LC-MS separation and detection of vitamin D metabolites 有权
    LC-MS分离和检测维生素D代谢物

    公开(公告)号：US09063159B2

    公开(公告)日：2015-06-23

    申请号：US13881843

    申请日：2011-10-28

    申请人： Joseph L. Herman ,  Dayana Argoti

    发明人： Joseph L. Herman ,  Dayana Argoti

    IPC分类号： G01N33/00 ,  G01N33/82

    CPC分类号： G01N33/82 ,  G01N2560/00 ,  Y10T436/203332

    摘要： Systems, kits, and methods for quantitation of metabolites of vitamin D by liquid chromatography-mass spectrometry (LC-MS). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([M+H]+) for the vitamin D metabolites in the ionization source (e.g., electrospray ionization (“ESI”)). Formation of the molecular ion does not involve loss of a water molecule from the parent molecule. Subsequent fragmentation of the [M+H]+ ion yields product ions that are specific to each molecular ion. The systems, kits, and methods described herein provide for no compromise in specificity and provide for a significant increase in sensitivity relative to previously described methods.

    摘要翻译： 通过液相色谱 - 质谱（LC-MS）定量维生素D代谢物的系统，试剂盒和方法。 本文所述的系统，试剂盒和方法稳定和/或促进电离源（例如，电喷雾离子化（“ESI”））中维生素D代谢物的质子化分子离子（[M + H] +）的形成）。 分子离子的形成不涉及从母体分子损失水分子。 随后的[M + H] +离子的断裂产生对每个分子离子特异的产物离子。 本文所述的系统，试剂盒和方法提供了特异性的妥协，并且提供了相对于先前描述的方法显着增加的灵敏度。

    LC-MS CONFIGURATION FOR PURIFICATION AND DETECTION OF ANALYTES HAVING A BROAD RANGE OF HYDROPHOBICITES
    9.
    发明申请
    LC-MS CONFIGURATION FOR PURIFICATION AND DETECTION OF ANALYTES HAVING A BROAD RANGE OF HYDROPHOBICITES 审中-公开
    用于净化和检测具有广泛的疏水性分析物的分析仪的LC-MS配置

    公开(公告)号：US20140047906A1

    公开(公告)日：2014-02-20

    申请号：US13881848

    申请日：2011-10-28

    申请人： Joseph L. Herman ,  Robert Dewitte ,  Dayana Argoti

    发明人： Joseph L. Herman ,  Robert Dewitte ,  Dayana Argoti

    IPC分类号： G01N30/72

    CPC分类号： G01N30/7233 ,  G01N30/32 ,  G01N30/34 ,  G01N30/88 ,  G01N33/6848 ,  G01N33/82 ,  G01N33/9493 ,  G01N2030/8813 ,  G01N2430/00

    摘要： Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system. The methods, systems, and kits described herein provide for substantially increased speed/throughput and ease of use for a wide range analytes with essentially no compromise in specificity for individual analytes relative to previously described methods.

    摘要翻译： 通过液相色谱 - 质谱（LC-MS）纯化和分析具有广泛疏水性的分析物的系统，设备，试剂盒和方法。 使用一套液相色谱柱，一组流动相缓冲液，以及任选的单一离子化方法（如电喷雾离子化），可以在液相色谱 - 质谱（LC- MS）系统。 通过选择不同类别分析物特有的LC运行参数和MS系统参数，而不必对列或缓冲区进行更改或对其进行任何其他硬件配置更改，从而实现具有宽范围分配系数的分析物的LC-MS纯化和分析。 LC-MS系统。 本文描述的方法，系统和试剂盒提供了对于宽范围分析物的显着提高的速度/通量和易用性，其相对于先前描述的方法基本上不损害针对各个分析物的特异性。