METHODS OF KILLING CELLS AND USE OF SAME IN PREVENTION AND TREATMENT OF CANCER
    1.
    发明申请
    METHODS OF KILLING CELLS AND USE OF SAME IN PREVENTION AND TREATMENT OF CANCER 有权
    杀死细胞的方法及其在预防和治疗癌症中的应用

    公开(公告)号:US20110076282A1

    公开(公告)日:2011-03-31

    申请号:US12994856

    申请日:2009-05-26

    IPC分类号: A61K39/395 C12Q1/48 A61P35/00

    CPC分类号: A61K45/06

    摘要: A method of killing a cell having a mutation in an Adenomatous polyposis coli (APC) gene is disclosed. The method comprises contacting the cell with an inhibitor of Casein kinase I (CKI), the CKI being selected from the group consisting of CKI-alpha and CKI-delta and CKI-epsilon, thereby killing the cell. The method may be used for treating cancers. Pharmaceutical compositions for treatment of cancers are also disclosed.

    摘要翻译: 公开了一种杀死Adenomatous polyposis coli(APC)基因突变细胞的方法。 该方法包括使细胞与酪蛋白激酶I(CKI)的抑制剂接触,CKI选自CKI-α和CKI-δ和CKI-ε,从而杀死细胞。 该方法可用于治疗癌症。 还公开了用于治疗癌症的药物组合物。