公开(公告)号：US20210052549A1

公开(公告)日：2021-02-25

申请号：US16492546

申请日：2018-03-07

Applicant: Marc Childs ,  Jacque Sauzieres ,  Olivier Petitjean ,  Guillaume Petitjean ,  Elodie Petitjean ,  Grégoire Petitjean

Inventor： Olivier Petitjean ,  Guillaume Petitjean ,  Elodie Petitjean ,  Grégoire Petitjean

IPC: A61K31/385 ,  A61K45/06 ,  A61K31/4709 ,  A61K47/55 ,  A61K31/5383 ,  A61K31/496 ,  A61K31/4468 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/222 ,  A61K31/5415 ,  A61P9/06

Abstract: A method of treating a subject for reducing the risk of QT space prolongation associated with the intake of a drug known to prolong QT space includes administering to the subject at least one specific inhibitor of mitochondrial ROS production selected from among anethole trithione (ATT), 4-OH-anethole trithione (ATX), and an ATX ester, and administering to the subject the drug known to prolong QT space.

公开(公告)号：US11554106B2

公开(公告)日：2023-01-17

申请号：US16492546

申请日：2018-03-07

Applicant: Marc Childs ,  Jacque Sauzieres ,  Olivier Petitjean ,  Guillaume Petitjean ,  Elodie Petitjean ,  Grégoire Petitjean

Inventor： Olivier Petitjean ,  Guillaume Petitjean ,  Elodie Petitjean ,  Grégoire Petitjean

IPC: A61K31/385 ,  A61K47/55 ,  A61P9/06 ,  A61K31/222 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/5415 ,  A61K45/06

Abstract: A method of treating a subject for reducing the risk of QT space prolongation associated with the intake of a drug known to prolong QT space includes administering to the subject at least one specific inhibitor of mitochondrial ROS production selected from among anethole trithione (ATT), 4-OH-anethole trithione (ATX), and an ATX ester, and administering to the subject the drug known to prolong QT space.