公开(公告)号：US06767895B2

公开(公告)日：2004-07-27

申请号：US09894882

申请日：2001-06-29

申请人： Craig S. Walker ,  Reshma Shetty ,  Elsie C. Jimenez ,  J. Michael McIntosh ,  Baldomero M. Olivera ,  Maren Watkins ,  Robert M. Jones ,  Gregory S. Shen

发明人： Craig S. Walker ,  Reshma Shetty ,  Elsie C. Jimenez ,  J. Michael McIntosh ,  Baldomero M. Olivera ,  Maren Watkins ,  Robert M. Jones ,  Gregory S. Shen

IPC分类号： A61K3816

CPC分类号： C07K14/43504

摘要： The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.

摘要翻译： 本发明涉及相对短的肽（本文中称为I-芋螺毒素），长度约30-50个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括四个 二硫键。

公开(公告)号：US06441132B1

公开(公告)日：2002-08-27

申请号：US09297771

申请日：1999-12-14

申请人： Elsie C. Jimenez ,  Baldomero M. Olivera ,  William R. Gray ,  Lourdes Cruz

发明人： Elsie C. Jimenez ,  Baldomero M. Olivera ,  William R. Gray ,  Lourdes Cruz

IPC分类号： C07K412

CPC分类号： C07K7/06 ,  A61K38/00

摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan residues. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys (SEQ ID NO:1), wherein Xaa1 is Gly or des-Xaa1, Xaa2 is Pro or 4-trans-hydroxyproline and Xaa3 is D-Trp or L-Trp, preferably D-Trp. The present invention is further directed to the peptides contryphan R and des-Gly1 contryphan R. In contryphan R, Xaa1 is Gly and Xaa3 is D-Trp. These contryphans are useful as anticonvulsant or neuroprotective agents.

摘要翻译： 本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸残基。 更具体地，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是Gly或des-Xaa1，Xaa2是Pro 或4-反式 - 羟基脯氨酸，Xaa3是D-Trp或L-Trp，优选D-Trp。 本发明进一步针对R和des-Gly1对应的肽。相反，Raa，Xaa1是Gly，Xaa3是D-Trp。 这些拮抗剂可用作抗惊厥药或神经保护剂。