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公开(公告)号：US06767895B2
公开(公告)日：2004-07-27
申请号：US09894882
申请日：2001-06-29
申请人： Craig S. Walker , Reshma Shetty , Elsie C. Jimenez , J. Michael McIntosh , Baldomero M. Olivera , Maren Watkins , Robert M. Jones , Gregory S. Shen
发明人： Craig S. Walker , Reshma Shetty , Elsie C. Jimenez , J. Michael McIntosh , Baldomero M. Olivera , Maren Watkins , Robert M. Jones , Gregory S. Shen
IPC分类号： A61K3816
CPC分类号： C07K14/43504
摘要： The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.
摘要翻译： 本发明涉及相对短的肽（本文中称为I-芋螺毒素），长度约30-50个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括四个 二硫键。
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公开(公告)号：US08487075B2
公开(公告)日：2013-07-16
申请号：US13367839
申请日：2012-02-07
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。
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公开(公告)号：US07279549B2
公开(公告)日：2007-10-09
申请号：US10895372
申请日：2004-07-21
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
IPC分类号： A61K38/10 , A61K38/17 , C07K7/08 , C07K714/435
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。
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公开(公告)号：US06797808B1
公开(公告)日：2004-09-28
申请号：US09493795
申请日：2000-01-28
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
IPC分类号： C07K700
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed &agr;-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。
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公开(公告)号：US07902153B2
公开(公告)日：2011-03-08
申请号：US12706911
申请日：2010-02-17
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对较短的肽（本文称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个 二硫键。
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公开(公告)号：US07666840B2
公开(公告)日：2010-02-23
申请号：US11869480
申请日：2007-10-09
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
IPC分类号： A61K38/10 , A61K38/17 , C07K7/08 , C07K14/435
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对较短的肽（本文称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个 二硫键。
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公开(公告)号：US06762165B2
公开(公告)日：2004-07-13
申请号：US09749637
申请日：2000-12-28
申请人： Baldomero M. Olivera , G. Edward Cartier , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Richard T. Layer , Robert M. Jones
发明人： Baldomero M. Olivera , G. Edward Cartier , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Richard T. Layer , Robert M. Jones
IPC分类号： C07K14435
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对较短的肽（本文中称为O超家族芋螺毒素），长度约20-40个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括 两个二硫键。
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公开(公告)号：US08110549B2
公开(公告)日：2012-02-07
申请号：US13042832
申请日：2011-03-08
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对较短的肽（本文称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个 二硫键。
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公开(公告)号：US06268473B1
公开(公告)日：2001-07-31
申请号：US09488799
申请日：2000-01-21
申请人： Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Robert M. Jones
发明人： Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Robert M. Jones
IPC分类号： C07K708
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed &agr;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The &agr;-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。 如本文所述，α-蛇毒毒素可用作神经肌肉阻滞剂，例如肌肉松弛剂。
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公开(公告)号：US07115708B2
公开(公告)日：2006-10-03
申请号：US11198847
申请日：2005-08-08
CPC分类号： C07K14/43504
摘要： The present invention is directed to β-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the β-superfamily conotoxin peptides and encoding β-superfamily conotoxin propeptides, as well as the β-superfamily conotoxin propeptides.
摘要翻译： 本发明涉及β-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码β-超家族荚果毒素肽和编码β-超家族荚果毒素前肽以及β-超家族荚果毒素前肽的核酸序列。
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