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16 条记录 (耗时 0.065 秒)

    Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as therapeutic compounds
    5.
    发明授权
    Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as therapeutic compounds 有权

    公开(公告)号：US07625922B2

    公开(公告)日：2009-12-01

    申请号：US11665640

    申请日：2005-10-21

    申请人： Dan Niculescu-Duvaz ,  Caroline Joy Springer ,  Adrian Liam Gill ,  Richard David Taylor ,  Richard Malcol Marais ,  Harmen Dijkstra ,  Catherine Gaulon ,  Delphine Menard ,  Esteban Roman Vela

    发明人： Dan Niculescu-Duvaz ,  Caroline Joy Springer ,  Adrian Liam Gill ,  Richard David Taylor ,  Richard Malcol Marais ,  Harmen Dijkstra ,  Catherine Gaulon ,  Delphine Menard ,  Esteban Roman Vela

    IPC分类号： A01N43/42 ,  A61K31/44 ,  A01N43/52 ,  C07D239/70 ,  C07D471/00 ,  C07D487/00 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particularly to compounds of the formula (I): wherein: J is independently —O— or —NRN1—; RN1, if present, is independently —H or a substituent; RN2 is independently —H or a substituent; Y is independently —CH═ or —N═; Q is independently —(CH2)j—M—(CH2)k— wherein: j is independently 0, 1 or 2; k is independently 0, 1, or 2; j+k is 0, 1, or 2; M is independently —O—, —S—, —NH—, —NMe—, or —CH2—; each of RP1, RP2, RP3, and RP4 is independently —H or a substituent; and additionally RP1 and RP2 taken together may be —CH═CH—CH═CH—; L is independently: a linker group formed by a chain of 2, 3, or 4 linker moieties; each linker moiety is independently —CH2—, —NRN—, —C(═X)—, or —S(═O)2—; exactly one linker moiety is —NRN—, or: exactly two linker moieties are —NRN—; exactly one linker moiety is —C(═X)—, and no linker moiety is —S(═O)2—; or: exactly one linker moiety is —S(═O)2—, and no linker moiety is —C(═X)—; no two adjacent linker moieties are —NRN—; X is independently ═O or ═S; each RN is independently —H or a substituent; A is independently: C6-14carboaryl, C5-14heteroaryl, C3-12carbocyclic, C3-12heterocyclic; and is independently unsubstituted or substituted; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, N-oxides, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., B-RAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and conditions that are ameliorated by the inhibition of RAF, RTK, etc., proliferative conditions such as cancer (e.g., colorectal cancer, melanoma), etc.

    Modulated video waveform generator
    7.
    发明授权
    Modulated video waveform generator 失效
    调制视频波形发生器

    公开(公告)号：US07480066B2

    公开(公告)日：2009-01-20

    申请号：US10903560

    申请日：2004-07-29

    申请人： Douglas Gene Keithley ,  Mark David Montierth ,  Richard David Taylor

    发明人： Douglas Gene Keithley ,  Mark David Montierth ,  Richard David Taylor

    IPC分类号： G06F3/12

    CPC分类号： H04N1/047 ,  H04N1/1135 ,  H04N1/12 ,  H04N2201/0082 ,  H04N2201/04767 ,  Y10T307/68 ,  Y10T307/691 ,  Y10T307/718

    摘要： A video controller includes a video block that connects to the print control engine and one laser driver. The video block includes a direct memory access (DMA) block, a video processor, a waveform generator including pattern and multiple pulse mode modulation, a frequency synthesizer, configuration registers, and a data bus. The frequency synthesizer connects to the waveform generator. The configuration registers connect to the DMA block, video processor and the waveform generator. The data bus, operative to carry bus control signals, connects the DMA block, video processor, waveform generator, and the configuration registers.

    摘要翻译： 视频控制器包括连接到打印控制引擎和一个激光驱动器的视频块。 视频块包括直接存储器访问（DMA）块，视频处理器，包括模式和多脉冲模式调制的波形发生器，频率合成器，配置寄存器和数据总线。 频率合成器连接到波形发生器。 配置寄存器连接到DMA块，视频处理器和波形发生器。 数据总线，用于传送总线控制信号，连接DMA块，视频处理器，波形发生器和配置寄存器。

    Variable frequency generator
    8.
    发明授权
    Variable frequency generator 有权

    公开(公告)号：US07145371B2

    公开(公告)日：2006-12-05

    申请号：US10903604

    申请日：2004-07-30

    申请人： Douglas Gene Keithley ,  Richard David Taylor ,  Mark David Montierth

    发明人： Douglas Gene Keithley ,  Richard David Taylor ,  Mark David Montierth

    IPC分类号： H03B19/00

    CPC分类号： H03L7/06

    摘要： A digital circuit generates very precise varying clock frequencies for applications that can tolerate a small degree of jitter but require exact longer term frequencies, e.g. a video clock for a laser printer. Some subpixel jitter is acceptable, but the overall pixel rate remains exact and consistent. In some applications, the jitter may be desirable to smear the EMI spectrum. For example, if the high frequency input clock is modulated, the edges of the video clock will also be modulated yet remain within the jitter and frequency specification.

    PROGRAMMABLE I/O INTERFACE
    9.
    发明申请
    PROGRAMMABLE I/O INTERFACE 有权
    可编程I / O接口

    公开(公告)号：US20110307634A1

    公开(公告)日：2011-12-15

    申请号：US13175481

    申请日：2011-07-01

    申请人： Richard David Taylor ,  Mark David Montierth ,  Douglas Gene Keithley

    发明人： Richard David Taylor ,  Mark David Montierth ,  Douglas Gene Keithley

    IPC分类号： G06F13/28

    CPC分类号： G06F13/385

    摘要： The invention provides an architecture and method for implementing a programmable I/O interface. The primary function provides a generic reconfigurable interface for serial communications between a laser printer controller and the print mechanism. The design also supports vertical page synchronization (top of page detection).

    摘要翻译： 本发明提供了一种用于实现可编程I / O接口的架构和方法。 主要功能为激光打印机控制器和打印机构之间的串行通信提供通用的可重新配置接口。 该设计还支持垂直页面同步（页首检测）。