公开(公告)号：US4230854A

公开(公告)日：1980-10-28

申请号：US888750

申请日：1978-03-21

申请人： Enzo Beacco ,  Maria L. Bianchi ,  Annacleto Minghetti ,  Celestino Spalla

发明人： Enzo Beacco ,  Maria L. Bianchi ,  Annacleto Minghetti ,  Celestino Spalla

IPC分类号： A61K31/48 ,  A61P25/06 ,  C07D519/02 ,  C12P1/00 ,  C12P17/18

CPC分类号： C12P17/183 ,  C07D519/02

摘要： Ergot alkaloids having interesting pharmacological activities, for instance in the therapy of migraine or hypertension. Such compounds are obtained in a fermentative process using mutant strains of Claviceps purpurea eventually hydrogenating the products thus obtained.

摘要翻译： 具有有趣的药理活性的生物碱，例如在偏头痛或高血压的治疗中。 这种化合物是在发酵过程中获得的，其中使用Claviceps purpurea的突变株最终氢化由此获得的产物。

公开(公告)号：US4196288A

公开(公告)日：1980-04-01

申请号：US856536

申请日：1977-12-01

申请人： Enzo Beacco ,  Luigi Bernardi ,  Enrico Di Salle ,  Giovanni Falconi ,  Bianca Patelli

发明人： Enzo Beacco ,  Luigi Bernardi ,  Enrico Di Salle ,  Giovanni Falconi ,  Bianca Patelli

IPC分类号： A61K31/48 ,  A61K31/495 ,  A61K31/505 ,  C07D457/02

CPC分类号： C07D457/02

摘要： New ergoline derivatives are disclosed which are compounds of formula (I) having the structure: ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or methyl; andX is hydroxy, R.sub.3 COO, S--R.sub.4 or NR.sub.5 R.sub.6 in which R.sub.3 is a straight or branched alkyl having from 1 to 6 carbon atoms, unsubstituted- or substituted-phenyl, the substituents being selected from the class consisting of chlorine, bromine, alkyl or alkoxy having from 1 to 4 carbon atoms, cycloalkyl containing from 3 to 6 carbon atoms, or a heterocycle;R.sub.4 is phenyl or a heterocycle, andR.sub.5 and R.sub.6 are alkyl having from 1 to 4 carbon atoms, or together with the N atom to which they are attached, forming a heterocycle. The heterocycle may be a 5- or 6-membered ring which contains from 1 to 3 hetero atoms selected from the class consisting of nitrogen, oxygen and sulphur, and may be saturated or unsaturated, and unsubstituted or substituted by halogen, alkyl having from 1 to 3 carbon atoms, hydroxy, nitro, amino, CONHNH.sub.2 and COOH.

摘要翻译： 公开了新的麦角灵衍生物，其是具有以下结构的式（I）的化合物：其中R 1是氢或甲氧基; R2是氢或甲基; 并且X是羟基，R 3 COO，S-R 4或NR 5 R 6，其中R 3是具有1至6个碳原子的直链或支链烷基，未取代或取代的苯基，所述取代基选自氯，溴，烷基 或具有1至4个碳原子的烷氧基，含3至6个碳原子的环烷基或杂环; R 4是苯基或杂环，R 5和R 6是具有1至4个碳原子的烷基，或与它们相连的N原子一起形成杂环。 杂环可以是含有1至3个选自氮，氧和硫的杂原子的5或6元环，并且可以是饱和或不饱和的，未取代的或被卤素取代的烷基，具有1个 至3个碳原子，羟基，硝基，氨基，CONHNH 2和COOH。