公开(公告)号：US20110093056A1

公开(公告)日：2011-04-21

申请号：US12977472

申请日：2010-12-23

申请人： Stephen L. Kaplan ,  Patrick H. Ruane ,  Eric A. Lang ,  Torsten Kimura

发明人： Stephen L. Kaplan ,  Patrick H. Ruane ,  Eric A. Lang ,  Torsten Kimura

IPC分类号： A61F2/84 ,  C23C16/50 ,  A61F2/82

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/826 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2210/0004 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  B05B13/0228 ,  B05B13/0442 ,  Y10T428/1352

摘要： Metallic stents are treated with a gaseous species in a plasma state under conditions causing the species to polymerize and to be deposited in polymerized form on the metallic stent surface prior to the application of a drug-polymer mixture, which is done by conventional non-plasma deposition methods. The drug-polymer mixture once applied forms a coating on the stent surface that releases the drug in a time-release manner and gradually erodes, leaving only the underlying plasma-deposited polymer. In certain cases, the plasma-deposited polymer itself erodes or dissolves into the physiological medium over an extended period of time, leaving only the metallic stent. While the various polymers and drug remain on the stent, the plasma-deposited polymer enhances the adhesion of the drug-polymer anchor coating and maintains the coating intact upon exposure to the mechanical stresses encountered during stent deployment.

摘要翻译： 在施加药物 - 聚合物混合物之前，在等离子体状态下，使物质聚合并以聚合形式沉积在金属支架表面上的条件下，处于等离子体状态的金属支架，其通过常规非等离子体 沉积方法。 一次施用的药物 - 聚合物混合物在支架表面上形成涂层，其以时间释放方式释放药物并逐渐侵蚀，仅留下下面的等离子体沉积聚合物。 在某些情况下，等离子体沉积的聚合物本身在延长的时间内侵蚀或溶解到生理介质中，仅留下金属支架。 虽然各种聚合物和药物保留在支架上，等离子体沉积的聚合物增强了药物 - 聚合物锚固涂层的粘附，并且在暴露于支架展开期间遇到的机械应力的同时保持涂层完整。