公开(公告)号：US20120064005A1

公开(公告)日：2012-03-15

申请号：US13320816

申请日：2010-05-26

Applicant: Christopher Cox ,  Broc A. Flores ,  Eric Hostetler ,  Hong Fan

Inventor： Christopher Cox ,  Broc A. Flores ,  Eric Hostetler ,  Hong Fan

IPC: A61K51/04 ,  C07D403/14 ,  G01T1/20 ,  C07D403/06

CPC classification number: A61K51/0459 ,  C07D239/74 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14

Abstract: The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals.

Abstract translation: 本发明涉及通用结构式I的放射性标记的嘧啶酮化合物，其可用作哺乳动物中PDE10定量成像的放射性示踪剂。

公开(公告)号：US20120121508A1

公开(公告)日：2012-05-17

申请号：US13386955

申请日：2010-07-20

Applicant: Ian M. Bell ,  Eric Hostetler ,  Harold G. Selnick ,  Craig A. Stump

Inventor： Ian M. Bell ,  Eric Hostetler ,  Harold G. Selnick ,  Craig A. Stump

IPC: A61K51/04 ,  A61P25/00 ,  C07D471/10

CPC classification number: C07D471/10 ,  C07B59/002 ,  C07D471/20

Abstract: The present invention is directed to radiolabeled CGRP receptor antagonists which are useful for the quantitative imaging of CGRP receptors in mammals.

Abstract translation: 本发明涉及放射性标记的CGRP受体拮抗剂，其可用于哺乳动物中CGRP受体的定量成像。

公开(公告)号：US20170119912A1

公开(公告)日：2017-05-04

申请号：US15317333

申请日：2015-06-09

Applicant: Abbas W. Walji ,  Eric Hostetler ,  Thomas J. Greshock ,  Jing Li ,  Keith P. Moore ,  Idriss Bennacef ,  James Mulhearn ,  Harold Selnick ,  Yaode Wang ,  Kun Yang ,  Jianmin Fu ,  MERCK SHARP & DOHME CORP.

Inventor： Abbas W. Walji ,  Eric Hostetler ,  Thomas J. Greshock ,  Jing Li ,  Keith P. Moore ,  Idriss Bennacef ,  James Mulhearn ,  Harold Selnick ,  Yaode Wang ,  Kun Yang ,  Jianmin Fu

IPC: A61K51/04 ,  C07D519/00 ,  C07D471/04

CPC classification number: A61K51/0455 ,  A61K51/0459 ,  C07B2200/05 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention is directed to pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology. The invention further relates to a method of measuring clinical efficacy of therapeutic agents for Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.

公开(公告)号：US08530483B2

公开(公告)日：2013-09-10

申请号：US12995314

申请日：2009-05-28

Applicant: James C. Barrow ,  Scott Harrison ,  James Mulhearn ,  Cyrille Sur ,  David L. Williams ,  Scott Wolkenberg ,  Eric Hostetler

Inventor： James C. Barrow ,  Scott Harrison ,  James Mulhearn ,  Cyrille Sur ,  David L. Williams ,  Scott Wolkenberg ,  Eric Hostetler

IPC: A01N43/90 ,  A01N43/42 ,  A61K31/519 ,  A61K31/44 ,  C07D239/00 ,  C07D471/00 ,  C07D491/00 ,  C07D513/02 ,  C07D515/02 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02

CPC classification number: C07D498/04 ,  C07D519/00

Abstract: The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S; A and Y independently are N, or CH.

Abstract translation: 本发明涉及式（I）的新型淀粉样蛋白结合化合物和通过测定活体患者淀粉样斑块水平的变化来测定化合物的效果的方法。 更具体地说，本发明涉及使用本发明化合物作为正电子发射断层摄影（PET /）成像中的示踪剂来研究脑中淀粉样蛋白沉积物以允许诊断阿尔茨海默病的方法。 因此，本发明涉及新型淀粉样蛋白结合化合物作为诊断用途。 本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。 具体地，本发明涉及新的芳基或杂芳基取代的氮杂苯并恶唑衍生物，组合物，以及用于制备这些化合物或其药学上可接受的盐，溶剂合物或体内可水解的酯的治疗用途和方法，其中：X是O或S; A和Y独立地为N或CH。

公开(公告)号：US20240344811A1

公开(公告)日：2024-10-17

申请号：US18298960

申请日：2023-04-11

Applicant: Eric Hostetler

Inventor： Eric Hostetler

IPC: F41G11/00

CPC classification number: F41G11/003

Abstract: The present invention relates to a rail interface system for mounting accessories to a firearm, including but not limited to, pistols and rifles. The present invention provides a means for mitigating the effects of recoil on rail interface systems by providing a lightweight mount, a clamp, and clamp screws that engage with the depressions and outermost edge of a firearm rail, while leaving the upwardly facing surface of the firearm rail open to an interior cavity. The upwardly facing surface of the rail interface system provides a means for fixedly mounting an accessory to the mount.

公开(公告)号：US08846000B2

公开(公告)日：2014-09-30

申请号：US13320816

申请日：2010-05-26

Applicant: Christopher D. Cox ,  Broc A. Flores ,  Eric Hostetler ,  Hong Fan

Inventor： Christopher D. Cox ,  Broc A. Flores ,  Eric Hostetler ,  Hong Fan

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61K51/0459 ,  C07D239/74 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14

Abstract: The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals.

Abstract translation: 本发明涉及通用结构式I的放射性标记的嘧啶酮化合物，其可用作哺乳动物中PDE10定量成像的放射性示踪剂。