公开(公告)号：US08747830B2

公开(公告)日：2014-06-10

申请号：US12663438

申请日：2008-06-10

Applicant: Erin A. Rayment ,  Tim Dargaville ,  Zee Upton

Inventor： Erin A. Rayment ,  Tim Dargaville ,  Zee Upton

IPC: A61K31/74

CPC classification number: C07F9/3873 ,  A61K47/58 ,  A61K47/6955 ,  A61L15/44 ,  A61L2300/112 ,  A61L2300/434

Abstract: The invention provides a dressing composition comprising a bisphosphonate matrix metalloproteinase (MMP) inhibitor covalently bound to a polymer wherein, when the dressing is contacted with a wound, substantially all of the bisphosphonate remains with the dressing composition and is unable to enter the wound tissue. The invention also provides for a method of treatment of a wound by contacting a dressing composition comprising a covalently bound MMP inhibitor with the wound fluid to thereby selectively inhibit one or more MMP's in the wound fluid without inhibiting those in the wound tissue.

Abstract translation: 本发明提供一种敷料组合物，其包含与聚合物共价结合的二膦酸酯基质金属蛋白酶（MMP）抑制剂，其中当敷料与伤口接触时，基本上所有的双膦酸盐都与敷料组合物保持不动，并且不能进入伤口组织。 本发明还提供了通过使包含共价结合的MMP抑制剂的敷料组合物与伤口液接触从而选择性地抑制伤口液中的一种或多种MMP而不抑制伤口组织中的那些的方法来治疗伤口。

公开(公告)号：US20100172860A1

公开(公告)日：2010-07-08

申请号：US12663438

申请日：2008-06-10

Applicant: Erin A. Rayment ,  Tim Dargaville ,  Zee Upton

Inventor： Erin A. Rayment ,  Tim Dargaville ,  Zee Upton

IPC: A61K31/74 ,  A61P17/02 ,  C08F120/10

CPC classification number: C07F9/3873 ,  A61K47/58 ,  A61K47/6955 ,  A61L15/44 ,  A61L2300/112 ,  A61L2300/434

Abstract: The invention provides a dressing composition comprising a bisphosphonate matrix metalloproteinase (MMP) inhibitor covalently bound to a polymer wherein, when the dressing is contacted with a wound, substantially all of the bisphosphonate remains with the dressing composition and is unable to enter the wound tissue. The invention also provides for a method of treatment of a wound by contacting a dressing composition comprising a covalently bound MMP inhibitor with the wound fluid to thereby selectively inhibit one or more MMP's in the wound fluid without inhibiting those in the wound tissue.

Abstract translation: 本发明提供一种敷料组合物，其包含与聚合物共价结合的二膦酸酯基质金属蛋白酶（MMP）抑制剂，其中当敷料与伤口接触时，基本上所有的双膦酸盐都与敷料组合物保持不动，并且不能进入伤口组织。 本发明还提供了通过使包含共价结合的MMP抑制剂的敷料组合物与伤口液接触从而选择性地抑制伤口液中的一种或多种MMP而不抑制伤口组织中的那些的方法来治疗伤口。