公开(公告)号：US4036951A

公开(公告)日：1977-07-19

申请号：US649891

申请日：1976-01-16

申请人： Alfred Halpern ,  Ernest J. Sasmor

发明人： Alfred Halpern ,  Ernest J. Sasmor

IPC分类号： A61K8/44 ,  A61Q17/04 ,  A61K7/44

CPC分类号： A61Q17/04 ,  A61K8/445 ,  Y10S424/13 ,  Y10S514/939

摘要： Alkyl esters of aminosalicylic acid, said alkyl group having from 1 to 18 carbon atoms in chain length; alkenyl esters of aminosalicylic acid, said alkenyl group selected from the group consisting of vinyl, allyl, undecenyl, oleyl and linolenyl groups, and cyclic esters of aminosalicylic acid, said cyclic group being the cyclohexyl, phenyl and menthyl groups, having ultra-violet screening properties to absorb light rays within the wave-length range of 2950 A. to 3200 A. while transmitting the light rays beyond the 3200 A. range to permit the desirable tanning of the skin without solar burn. The respective esters of aminosalicylic acid are prepared by the reduction of the appropriate nitro-salicylic acid ester with Raney nickel and hydrogen in the presence of ethyl acetate. The respective esters are obtained as oils or solid crystalline substances and are soluble in alcohols, chloroform, acetone and benzene but insoluble in water. The ultra-violet absorption spectra for the respective compounds are described. Compositions comprising the above compounds together with the method for their preparation and the method for the use to achieve an ultraviolet filtering action on the skin of humans and animals are described.

摘要翻译： 氨基水杨酸的烷基酯，所述烷基具有1至18个碳原子的链长; 所述烯基选自乙烯基，烯丙基，十一碳烯基，油烯基和亚麻基，氨基水杨酸的环状酯，所述环状基团是环己基，苯基和薄荷基，具有紫外线筛选 在2900A至3200A的波长范围内吸收光线的特性，同时将光线透射超过3200A的范围，以允许期望的鞣制皮肤而不需要太阳能燃烧。 氨基水杨酸的各自酯通过在乙酸乙酯存在下用阮内镍和氢还原适当的硝基 - 水杨酸酯来制备。 各酯是作为油或固体结晶物质得到的，可溶于醇，氯仿，丙酮和苯，但不溶于水。 描述各化合物的紫外吸收光谱。 描述了包含上述化合物的组合物及其制备方法以及用于在人和动物的皮肤上实现紫外线过滤作用的方法。

公开(公告)号：US4364929A

公开(公告)日：1982-12-21

申请号：US145232

申请日：1980-04-30

申请人： Ernest J. Sasmor ,  Kenneth G. Rothwell

发明人： Ernest J. Sasmor ,  Kenneth G. Rothwell

IPC分类号： A61K31/74 ,  A61L29/16 ,  A61K31/79 ,  A61K33/18 ,  H01B1/06

CPC分类号： A61K31/74 ,  A61L29/16 ,  A61L2300/106 ,  A61L2300/404 ,  A61L2300/452

摘要： Germicidal properties are provided for colloidal lubricating gels without destruction of the physical properties of the colloidal gel by the incorporation therein of an iodophor within strict limits as to the quantities and relative quantities of the iodophor-former, the iodine and the gel-forming colloid. These germicidal colloidal lubricating gels remain stable and retain their germicidal effectiveness. As a result, these compositions can be used for the lubrication of catheters and other instruments to facilitate their insertion into a body cavity and because these compositions do not cause pain or irritation their use reduces the risk of infection and tissue-trauma.

摘要翻译： 为胶体润滑凝胶提供杀菌性能，不会因为碘伏形成剂，碘和凝胶形成胶体的数量和相对量在严格的限度内掺入碘胶体而破坏胶体凝胶的物理性能。 这些杀菌胶体润滑凝胶保持稳定并保持其杀菌效果。 因此，这些组合物可以用于导管和其他器械的润滑以便于它们插入体腔，并且由于这些组合物不引起疼痛或刺激，因此它们的使用降低了感染和组织创伤的风险。

公开(公告)号：US4067974A

公开(公告)日：1978-01-10

申请号：US705056

申请日：1976-07-14

申请人： Ernest J. Sasmor

发明人： Ernest J. Sasmor

IPC分类号： A61K31/60 ,  A61K20060101 ,  A61K9/00 ,  A61K47/00 ,  A61K47/12 ,  A61K47/38 ,  C07C20060101 ,  A61K31/61 ,  A61K31/615

CPC分类号： A61K31/621 ,  A61K31/60

摘要： Choline salicylate is stabilized in solid form by means of a metal salicylate having a valence of at least 2, preferably aluminum, bismuth, calcium or magnesium salicylate. The composition is stabilized to a still greater degree by the addition thereto of carboxy-methyl cellulose. A still greater degree of stabilization is achieved by forming a complex of the choline salicylate, metal salicylate and carboxy-methyl cellulose. The complex is formed by preparing a solution of the carboxy-methyl cellulose, choline salicylate and metal salicylate, permitting complexng reaction to take place and drying. All of these stabilized forms of choline salicylate are used in solid dosage forms such as granules, tablets, capsules and supporitories for administration to animals and humans, in the course of choline salicylate therapy, to elevate the blood levels of salicylate ion.

摘要翻译： 水杨酸胆碱通过具有至少2价，优选铝，铋，钙或镁水杨酸盐的水杨酸金属稳定化。 通过加入羧甲基纤维素将组合物稳定到更大程度。 通过形成水杨酸胆碱，水杨酸金属盐和羧甲基纤维素的络合物可以获得更大程度的稳定化。 通过制备羧甲基纤维素，水杨酸胆碱和金属水杨酸盐的溶液来形成络合物，允许复合反应发生和干燥。 所有这些稳定化形式的水杨酸胆碱在用于水杨酸胆碱治疗的过程中用于固体剂型例如颗粒剂，片剂，胶囊和用于给予动物和人的支持物，以提高水杨酸根离子的血液水平。