Method and composition for the treatment of thrombosis in a mammal
    2.
    发明授权
    Method and composition for the treatment of thrombosis in a mammal 失效
    用于治疗哺乳动物血栓形成的方法和组合物

    公开(公告)号:US5503850A

    公开(公告)日:1996-04-02

    申请号:US352975

    申请日:1994-12-09

    CPC分类号: A61K38/166 A61K9/127

    摘要: A composition comprising a plurality of microcapsules suitable for parenteral injection into a mammal comprising a plasminogen activator-containing core, and a semi-permeable biocompatible layer surrounding the core permitting controlled release of at least a portion of the plasminogen activator. A method of reducing the time required for reperfusion of an artery containing a thrombus and a method to reduce the standard dosage requirement of a plasminogen activator in a mammal comprising intravenous injection of a composition comprising a plurality of microcapsules comprising a plasminogen activator core surrounded by a controlled release semi-permeable layer.

    摘要翻译: 一种组合物,其包含适合于肠胃外注射到哺乳动物中的多个微胶囊,所述哺乳动物包含含有纤溶酶原激活物的核心,以及围绕所述核心的半渗透生物相容层,允许至少部分纤溶酶原激活物的控制释放。 减少包含血栓的动脉再灌注所需的时间的方法和减少哺乳动物中纤溶酶原激活剂的标准剂量需求的方法,包括静脉内注射包含多个微胶囊的组合物,所述组合物包含纤维蛋白溶酶原激活物核心 控释半透层。