公开(公告)号：US20060263354A1

公开(公告)日：2006-11-23

申请号：US11410886

申请日：2006-04-24

申请人： Eva Rose Chin ,  Larry Green ,  Chikwendu Ibebunjo ,  Philip Krasney ,  Junming Yie ,  Joseph Zachwieja

发明人： Eva Rose Chin ,  Larry Green ,  Chikwendu Ibebunjo ,  Philip Krasney ,  Junming Yie ,  Joseph Zachwieja

IPC分类号： A61K39/00 ,  C07K16/28

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to myostatin, and that function to inhibit myostatin. The invention also relates to human anti-myostatin antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-myostatin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-myostatin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-myostatin antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

摘要翻译： 本发明涉及结合肌生成抑制素的抗体，包括人抗体及其抗原结合部分，并且其功能是抑制肌生成抑制素。 本发明还涉及人抗肌生成抑制素抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗肌生成抑制素抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗肌生成抑制素抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗肌生成抑制素抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。

公开(公告)号：US20110091455A1

公开(公告)日：2011-04-21

申请号：US12869060

申请日：2010-08-26

申请人： Eva Rose Chin ,  Larry L. Green ,  Chikwendu Ibebunjo ,  Philip Albert Krasney ,  Junming Yie ,  Joseph Zachwieja

发明人： Eva Rose Chin ,  Larry L. Green ,  Chikwendu Ibebunjo ,  Philip Albert Krasney ,  Junming Yie ,  Joseph Zachwieja

IPC分类号： A61K39/395 ,  A61P21/06

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to myostatin, and that function to inhibit myostatin. The invention also relates to human anti-myostatin antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-myostatin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-myostatin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-myostatin antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

摘要翻译： 本发明涉及结合肌生成抑制素的抗体，包括人抗体及其抗原结合部分，并且其功能是抑制肌生成抑制素。 本发明还涉及人抗肌生成抑制素抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗肌生成抑制素抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗肌生成抑制素抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗肌生成抑制素抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。

公开(公告)号：US07807159B2

公开(公告)日：2010-10-05

申请号：US11410886

申请日：2006-04-24

申请人： Eva Rose Chin ,  Larry L. Green ,  Chikwendu Ibebunjo ,  Philip Albert Krasney ,  Junming Yie ,  Joseph Zachweija

发明人： Eva Rose Chin ,  Larry L. Green ,  Chikwendu Ibebunjo ,  Philip Albert Krasney ,  Junming Yie ,  Joseph Zachweija

IPC分类号： A61K39/00 ,  C07K16/28

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to myostatin, and that function to inhibit myostatin. The invention also relates to human anti-myostatin antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-myostatin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-myostatin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-myostatin antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

摘要翻译： 本发明涉及结合肌生成抑制素的抗体，包括人抗体及其抗原结合部分，并且其功能是抑制肌生成抑制素。 本发明还涉及人抗肌生成抑制素抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗肌生成抑制素抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗肌生成抑制素抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗肌生成抑制素抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。