公开(公告)号：US08518105B2

公开(公告)日：2013-08-27

申请号：US11726647

申请日：2007-03-21

申请人： Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Thierry Glauser ,  Yiwen Eveleen Tang ,  Eugene T. Michal

发明人： Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Thierry Glauser ,  Yiwen Eveleen Tang ,  Eugene T. Michal

IPC分类号： A61F2/06 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： A61L31/043 ,  A61L2430/36

摘要： A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.

公开(公告)号：US20090030505A1

公开(公告)日：2009-01-29

申请号：US11881668

申请日：2007-07-27

申请人： Lothar W. Kleiner ,  Eveleen Tang

发明人： Lothar W. Kleiner ,  Eveleen Tang

IPC分类号： A61F2/82

CPC分类号： A61M25/0045 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08 ,  C08L67/04

摘要： The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular diseases.

摘要翻译： 本发明涉及涂覆有附着于其上的具有血液相容性和/或预热部分的聚合物的可植入医疗器械及其在治疗血管疾病中的用途。

公开(公告)号：US20090005849A1

公开(公告)日：2009-01-01

申请号：US11726647

申请日：2007-03-21

申请人： Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Thierry Glauser ,  Yiwen Eveleen Tang ,  Eugene T. Michal

发明人： Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Thierry Glauser ,  Yiwen Eveleen Tang ,  Eugene T. Michal

IPC分类号： A61K31/337 ,  A61M25/10 ,  A61F2/82 ,  A61F2/84 ,  A61P9/00

CPC分类号： A61L31/043 ,  A61L2430/36

摘要： A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.

摘要翻译： 描述了一种处理容器区域的方法和装置。 将蛋白质弹性蛋白基聚合物从装置中释放出来，作为主要疗法或辅助治疗来涂覆血管衬里，随着具有或不具有药物涂层的支架的递送和展开。 基于蛋白质弹性蛋白的聚合物可以包括具有弹性蛋白五肽作为侧翼嵌段的三嵌段结构和作为中间嵌段的五肽的亲水性变体。 可以改变侧面和中间嵌段以改变聚合物的结构和化学性质。 特别地，基于蛋白质弹性蛋白的聚合物适于执行控制治疗剂释放，刺激内皮细胞生长和稳定易损斑块中的至少一种，以防止脆弱斑块的破裂。