公开(公告)号：US06342503B1

公开(公告)日：2002-01-29

申请号：US09004150

申请日：1998-01-07

申请人： Paul Edward Aldrich ,  Argyrios Georgios Arvanitis ,  Robert Scott Cheeseman ,  Robert John Chorvat ,  Thomas Eugene Christos ,  Paul Joseph Gilligan ,  Dimitri Emil Grigoriadis ,  Carl Nicholas Hodge ,  Paul John Krenitsky ,  Everett Latham Scholfield ,  Sang William Tam ,  Zelda Rakowitz Wasserman

发明人： Paul Edward Aldrich ,  Argyrios Georgios Arvanitis ,  Robert Scott Cheeseman ,  Robert John Chorvat ,  Thomas Eugene Christos ,  Paul Joseph Gilligan ,  Dimitri Emil Grigoriadis ,  Carl Nicholas Hodge ,  Paul John Krenitsky ,  Everett Latham Scholfield ,  Sang William Tam ,  Zelda Rakowitz Wasserman

IPC分类号： C07D23942

CPC分类号： C07D213/74 ,  A61K31/44 ,  A61K31/505 ,  A61K31/53 ,  A61K31/535 ,  C07D239/42 ,  C07D239/48 ,  C07D251/18 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04

摘要： The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer'disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R4, R5, Z, Y, V, X, X′, J, K, L, and M are as defined herein.

摘要翻译： 本发明提供了新的化合物，其化合物及其药物组合物及其在治疗情感障碍，焦虑，抑郁，创伤后应激障碍，进食障碍，核核后麻痹，肠易激综合征，免疫抑制，阿尔茨海默病 疾病，胃肠道疾病，神经性厌食症，药物和酒精戒断症状，​​药物成瘾，炎性疾病或生殖问题。 本发明提供的新化合物是下式的化合物：其中R1，R3，R4，R5，Z，Y，V，X，X'，J，K，L和M如本文所定义。