公开(公告)号：US20170196862A2

公开(公告)日：2017-07-13

申请号：US14876525

申请日：2015-10-06

Applicant: Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

Inventor： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

IPC: A61K31/506 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/44 ,  C07D213/84 ,  C07D231/14 ,  A61K31/415 ,  C07D209/42 ,  A61K31/404 ,  C07D401/12 ,  A61K31/4439 ,  C07D401/14 ,  C07D231/12 ,  A61K31/497 ,  C07D417/12 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4525 ,  A61J1/03 ,  C07D213/82

CPC classification number: A61K31/506 ,  A61J1/035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  C07D209/18 ,  C07D209/42 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D213/82 ,  C07D213/84 ,  C07D231/12 ,  C07D231/14 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：US06342503B1

公开(公告)日：2002-01-29

申请号：US09004150

申请日：1998-01-07

Applicant: Paul Edward Aldrich ,  Argyrios Georgios Arvanitis ,  Robert Scott Cheeseman ,  Robert John Chorvat ,  Thomas Eugene Christos ,  Paul Joseph Gilligan ,  Dimitri Emil Grigoriadis ,  Carl Nicholas Hodge ,  Paul John Krenitsky ,  Everett Latham Scholfield ,  Sang William Tam ,  Zelda Rakowitz Wasserman

Inventor： Paul Edward Aldrich ,  Argyrios Georgios Arvanitis ,  Robert Scott Cheeseman ,  Robert John Chorvat ,  Thomas Eugene Christos ,  Paul Joseph Gilligan ,  Dimitri Emil Grigoriadis ,  Carl Nicholas Hodge ,  Paul John Krenitsky ,  Everett Latham Scholfield ,  Sang William Tam ,  Zelda Rakowitz Wasserman

IPC: C07D23942

CPC classification number: C07D213/74 ,  A61K31/44 ,  A61K31/505 ,  A61K31/53 ,  A61K31/535 ,  C07D239/42 ,  C07D239/48 ,  C07D251/18 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04

Abstract: The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer'disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R4, R5, Z, Y, V, X, X′, J, K, L, and M are as defined herein.

Abstract translation: 本发明提供了新的化合物，其化合物及其药物组合物及其在治疗情感障碍，焦虑，抑郁，创伤后应激障碍，进食障碍，核核后麻痹，肠易激综合征，免疫抑制，阿尔茨海默病 疾病，胃肠道疾病，神经性厌食症，药物和酒精戒断症状，​​药物成瘾，炎性疾病或生殖问题。 本发明提供的新化合物是下式的化合物：其中R1，R3，R4，R5，Z，Y，V，X，X'，J，K，L和M如本文所定义。