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公开(公告)号:US20160060324A1
公开(公告)日:2016-03-03
申请号:US14786419
申请日:2014-04-18
IPC分类号: C07K14/755 , A61K38/37 , A61K47/48
CPC分类号: C07K14/755 , A61K38/00 , A61K38/37 , A61K47/6425
摘要: The present invention provides immune conjugates for inducing antigen specific immune tolerance to coagulation Factor VIII. The immune conjugates contain a FVIII protein or antigenic fragment that is conjugated to a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods of using the FVIII immune conjugates to induce immune tolerance to FVIII in a subject. Additionally provided in the invention are methods for treating bleeding disorders such as hemophilia A via the use of the FVIII immune conjugates and an unconjugated FVIII with coagulating activity.
摘要翻译: 本发明提供用于诱导对凝血因子VIII的抗原特异性免疫耐受性的免疫结合物。 免疫缀合物含有与B细胞上表达的唾液酸结合Ig样凝集素(Siglec)的结合部分缀合的FVIII蛋白或抗原性片段。 本发明还提供使用FVIII免疫缀合物诱导受试者对FVIII的免疫耐受的方法。 本发明另外提供的是通过使用FVIII免疫缀合物和具有凝结活性的非共轭FVIII来治疗出血性疾病如血友病A的方法。