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公开(公告)号：US20160060324A1
公开(公告)日：2016-03-03
申请号：US14786419
申请日：2014-04-18
IPC分类号： C07K14/755 , A61K38/37 , A61K47/48
CPC分类号： C07K14/755 , A61K38/00 , A61K38/37 , A61K47/6425
摘要： The present invention provides immune conjugates for inducing antigen specific immune tolerance to coagulation Factor VIII. The immune conjugates contain a FVIII protein or antigenic fragment that is conjugated to a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods of using the FVIII immune conjugates to induce immune tolerance to FVIII in a subject. Additionally provided in the invention are methods for treating bleeding disorders such as hemophilia A via the use of the FVIII immune conjugates and an unconjugated FVIII with coagulating activity.
摘要翻译： 本发明提供用于诱导对凝血因子VIII的抗原特异性免疫耐受性的免疫结合物。 免疫缀合物含有与B细胞上表达的唾液酸结合Ig样凝集素（Siglec）的结合部分缀合的FVIII蛋白或抗原性片段。 本发明还提供使用FVIII免疫缀合物诱导受试者对FVIII的免疫耐受的方法。 本发明另外提供的是通过使用FVIII免疫缀合物和具有凝结活性的非共轭FVIII来治疗出血性疾病如血友病A的方法。
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公开(公告)号：US20130171233A1
公开(公告)日：2013-07-04
申请号：US13261580
申请日：2011-07-29
IPC分类号： A61K39/385 , A61K9/127
CPC分类号： A61K39/0008 , A61K9/127 , A61K39/001 , A61K39/35 , A61K39/385 , A61K47/6911 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555
摘要： The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition that co-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
摘要翻译： 本发明提供用于诱导免疫耐受的脂质体组合物。 化合物通常包含显示特异性抗原的脂质体，以及用于在B细胞上表达的唾液酸结合Ig样凝集素（Siglec）的结合部分。 本发明还提供了诱导受试者中蛋白质或多肽抗原（例如，蛋白质抗原）的耐受性的方法。 所述方法包括对受试者施用共同呈递在B淋巴细胞上表达的Siglec的抗原和聚糖配体的药物组合物。
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公开(公告)号：US09522183B2
公开(公告)日：2016-12-20
申请号：US13261580
申请日：2011-07-29
IPC分类号： A61K39/385 , A61K9/127 , A61K39/00 , A61K39/35 , A61K47/48
CPC分类号： A61K39/0008 , A61K9/127 , A61K39/001 , A61K39/35 , A61K39/385 , A61K47/6911 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555
摘要： The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec)expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition that co-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
摘要翻译： 本发明提供用于诱导免疫耐受的脂质体组合物。 化合物通常包含显示特异性抗原的脂质体，以及用于在B细胞上表达的唾液酸结合Ig样凝集素（Siglec）的结合部分。 本发明还提供了诱导受试者中蛋白质或多肽抗原（例如，蛋白质抗原）的耐受性的方法。 所述方法包括对受试者施用共同呈递在B淋巴细胞上表达的Siglec的抗原和聚糖配体的药物组合物。
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4.发明授权公开(公告)号：US10994006B2
公开(公告)日：2021-05-04
申请号：US16315796
申请日：2017-07-07
IPC分类号： A61K39/385 , A61K49/00 , A61K9/127 , A61K45/06 , A61K31/7028 , A61K31/7056 , A61K47/69 , A61K31/702 , A61K39/395 , A61K39/00
摘要： Compositions and methods are described herein that are useful for treating and inhibiting allergic conditions, including reducing the incidence of mast cell mediated anaphylaxis in subjects. The compositions include a carrier that displays an antigen and a Siglec ligand that binds to a Siglec on a mast cell.
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公开(公告)号：US20230037822A1
公开(公告)日：2023-02-09
申请号：US17755382
申请日：2020-10-28
发明人： James C. Paulson , Maidul Islam , Fabian Pfrengle , Matthew Macauley , Shiteng Duan , Britni Arlian
摘要： Described herein are Siglec ligand-antibody conjugates and compositions thereof that are useful for suppressing unwanted immune responses such as allergies and anaphylaxis.
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公开(公告)号：US20170165333A1
公开(公告)日：2017-06-15
申请号：US15370313
申请日：2016-12-06
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K9/127 , A61K39/001 , A61K39/35 , A61K39/385 , A61K47/6911 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555
摘要： The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition thatco-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
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7.发明申请公开(公告)号：US20190151444A1
公开(公告)日：2019-05-23
申请号：US16315796
申请日：2017-07-07
IPC分类号： A61K39/385 , A61K39/395 , A61K47/69 , A61K31/702
摘要： Compositions and methods are described herein that are useful for treating and inhibiting allergic conditions, including reducing the incidence of mast cell mediated anaphylaxis in subjects. The compositions include a carrier that displays an antigen and a Siglec ligand that binds to a Siglec on a mast cell.
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公开(公告)号：US09981023B2
公开(公告)日：2018-05-29
申请号：US15370313
申请日：2016-12-06
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K9/127 , A61K39/001 , A61K39/35 , A61K39/385 , A61K47/6911 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555
摘要： The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition thatco-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
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公开(公告)号：US5753631A
公开(公告)日：1998-05-19
申请号：US457886
申请日：1995-05-31
IPC分类号： A61K9/127 , A61K31/70 , A61K31/715 , A61K35/12 , A61K38/13 , A61K47/48 , C07H3/06 , C07H15/04 , C07H15/10 , C07K16/18 , C12N9/10 , G01N33/569 , C07H15/00
CPC分类号： C07H15/10 , A61K31/70 , A61K31/715 , A61K47/48023 , A61K47/48046 , A61K47/48092 , A61K47/48546 , A61K47/48815 , A61K9/1271 , C07H15/04 , C07H3/06 , C07K16/18 , C12N9/1051 , G01N33/56972
摘要： The present invention is directed towards compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions mediated by intercellular adhesion. The compositions of the invention include compounds that selectively bind selectin receptors, the selectin binding activity being mediated by a carbohydrate moiety. The selectin-binding moieties of the invention are derivatives of a sialylated, fucosylated N-acetyllactosamine unit of the Lewis X antigen. Compounds containing a selectin-binding moiety in both monovalent and multivalent forms are included in the invention. The compounds of the invention are provided as pharmaceutical compositions which include, for example, liposomes that carry selectin-binding moieties of the invention. The invention further includes immunoglobulins capable of selectively binding an oligosaccharide ligand that is recognized by a selectin receptor.
摘要翻译： 本发明涉及用于减少或控制炎症和治疗由细胞间粘附介导的炎性疾病过程和其它病理状况的组合物和方法。 本发明的组合物包括选择性结合选择素受体的选择素结合活性由碳水化合物部分介导的化合物。 本发明的选择素结合部分是Lewis X抗原的唾液酸化，岩藻糖化N-乙酰基乳糖胺单元的衍生物。 包含单价和多价形式的选择蛋白结合部分的化合物包括在本发明中。 本发明的化合物作为药物组合物提供，其包括例如携带本发明选择蛋白结合部分的脂质体。 本发明还包括能够选择性结合由选择素受体识别的寡糖配体的免疫球蛋白。
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10.发明授权Method for producing secretable glycosyltransferases and other Golgi processing enzymes 失效生产可分泌糖基转移酶和其他高尔基体加工酶的方法
公开(公告)号：US5032519A
公开(公告)日：1991-07-16
申请号：US426577
申请日：1989-10-24
CPC分类号： C12N9/1051 , C12P19/18 , C12P19/26
摘要： A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a rThis invention was made with government support under Grant Contract Nos. GM-27904 and GM-11557 awarded by the National Institute of Health. The government has certain rights in this invention. The publications and other reference materials referred to herein to describe the background of the invention and to provide additional detail regarding its practice are hereby incorporated by reference. For convenience, the reference materials are numerically referenced and grouped in the appended bibliography.
摘要翻译： 一种用于遗传工程细胞产生可溶性和可分泌的高尔基体加工酶而不是天然存在的膜结合酶的方法。 细胞被遗传工程化以表达缺少膜锚定和保留信号的糖基转移酶。 所得到的改变的酶变得可溶并且可被细胞分泌而不失去其催化活性。 由细胞分泌可溶性糖基转移酶提供增加的糖基转移酶的产生和简化的恢复。
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